Detection of antibodies to Angiostrongylus cantonensis in serum and cerebrospinal fluid of patients with eosinophilic meningitis

C, Yen; Chen, Eng-Rin

doi:10.1016/0020-7519(91)90116-o

Cited by 35 publications

(2 citation statements)

References 9 publications

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“…Immunodiagnostic tests for angiostrongyliasis using purified antigens or monoclonal antibodies have been available for decades. The earliest enzyme-linked immunosorbant assays (ELISAs) were developed using crude or partially purified adult A. cantonensis antigens (Chuan-Min and Eng-Rin, 1991). Two immunodominant A. cantonensis antigens were identified; a 29 and a 31 kDa antigen, and most immunoassays described target these (Wilkins et al 2013) (Table 4).…”

Section: Diagnosismentioning

confidence: 99%

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

et al. 2016

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Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography. Serological tests are available for angiostrongyliasis, though many tests are still under development. While there is no treatment consensus, therapy often includes a combination of anthelmintics and corticosteroids. Angiostrongyliasis is relatively rare, but is often associated with morbidity and sometimes mortality. Recent reports suggest the parasites' range is increasing, leading to fatalities in regions previously considered Angiostrongylus-free, and sometimes, delayed diagnosis in newly invaded regions. Increased awareness of angiostrongyliasis would facilitate rapid diagnosis and improved clinical outcomes. This paper summarizes knowledge on the parasites' life cycle, clinical aspects and epidemiology. The molecular biology of Angiostrongylus spp. is also discussed. Attention is paid to the significance of angiostrongyliasis in Australia, given the recent severe cases reported from the Sydney region.

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Section: Diagnosismentioning

confidence: 99%

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

et al. 2016

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“…Sensitivity is not yet determined and would be low because there is a lag between neurological symptoms and detection of antibodies in serum or CSF. Other inhouse ELISA estimate sensitivity between 83 and 97% and specificity between 80 and 100% [ 34 ]. Early CSF and serum samples will give a false negative result.…”

Section: Methodsmentioning

confidence: 99%

Eosinophilic meningitis in New Caledonia: The role of Angiostrongylus cantonensis?

et al. 2021

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Introduction Eosinophilic meningitis is a rare form of meningitis with sequelae or death occurring in approximately 2–3% of cases. The most frequent etiological agent is the parasite Angiostrongylus cantonensis. The aim of this study was to characterize New Caledonian cases and to assess the extent to which of A. cantonensis was involved. Material and methods We performed a retrospective study of all cases of eosinophilic meningitis (EM) admitted to the Territorial Hospital of New Caledonia, from 2004 to 2019. We performed a descriptive and a multivariate analysis to identify association of variables with severe and fatal cases (or cases with sequelae). Conclusion Angiostrongyliasis was confirmed as being responsible for 17 of the 92 reported EM cases in New Caledonia from 2004 to 2019 with most being young adults and non-walking infants, and with two peaks of incidence one during the dry season and one during the rainy season. Considering the high incidence and regularity of cases, the potential reservoirs should be identified to target prevention campaigns.

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Angiostrongylus(Parastrongylus) and Less Common Nematodes

Yoshimura

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Detection of antibodies to Angiostrongylus cantonensis in serum and cerebrospinal fluid of patients with eosinophilic meningitis

Cited by 35 publications

References 9 publications

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

Eosinophilic meningitis in New Caledonia: The role of Angiostrongylus cantonensis?

Angiostrongylus(Parastrongylus) and Less Common Nematodes

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