Detection of antifungal compounds in Polygonum ferrugineum Wedd. extracts by bioassay-guided fractionation. Some evidences of their mode of action

López, Silvia N.; Furlán, Ricardo L. E.; Zacchino, Susana

doi:10.1016/j.jep.2011.09.038

Cited by 24 publications

(15 citation statements)

References 17 publications

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“…Regarding T. cruzi, it is interesting to note that compound 1 showed better trypanocidal activity (IC 50 of 9.5 µM; ▶ Table 1) than the unsubstituted chalcone, which was reported by Lunardi et al [20] as the best of a series of synthetic chalcones (IC 50 of 24.8 µM). Regarding antifungal activity, compound 1 was inactive when tested, in contrast with the unsubstituted chalcone, which was the most active molecule, as shown previously [13,14]. These results show the importance of substituents in chalcones, which certainly determine bioactivity and could suggest some selectivity of compound 1 as a trypanocidal agent.…”

Section: Resultssupporting

confidence: 73%

“…2). The isolation and antifungal ac-tivity of compounds 3 and 4 was previously reported from the dichloromethanic extract of the aerial parts from this species [12,13].…”

Section: Resultsmentioning

confidence: 84%

“…(Polygonaceae) is a bush commonly found in temperate climates of South America on the boundaries of rivers, and accumulates mostly chalcones, flavanones, and homoisoflavanones among its secondary metabolites [12]. López et al [13] studied the antifungal activity of the species and demonstrated that chalcones pashanone and cardamonin isolated from a crude EDB of its aerial parts displayed high antifungal activity.…”

Section: Introductionmentioning

confidence: 99%

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Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

et al. 2016

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The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both (IC = 9.5 µM, IC = 34.7 µM benznidazol, Y strain) epimastigotes and (IC = 4.8 µM, IC = 6.4 µM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on strain 427 (IC = 6.2 µM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the -splicing inhibitory potential on cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.

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Section: Resultssupporting

confidence: 73%

“…2). The isolation and antifungal ac-tivity of compounds 3 and 4 was previously reported from the dichloromethanic extract of the aerial parts from this species [12,13].…”

Section: Resultsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

et al. 2016

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“…Therefore, based on these spectroscopic data, compound 2 was identified as 2',6'-dihydroxy-4'-methoxychalcone, trivial name pinostrobin chalcone, previously reported from bark of Lindera umbellate [7]. to be 2′,6′-dihydroxy-3′, 4′-dimethoxychalcone, trivial name pashanone (3), a compound previously isolated from Polygonum ferrugineum and Polygonum hydropiper [8,9].…”

Section: Resultsmentioning

confidence: 94%

Antimicrobial Chalcones from the Seeds of Persicaria lapathifolia

Hailemariam¹,

Feyera²,

Deyou³

et al. 2018

Biochem Pharmacol

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Bioassay-guided sequential extraction of the seeds of Persicaria lapathifolia followed by chromatographic separations resulted in the identification of three chalcones; flavokawain B (1), pinostrobin chalcone (2) and pashanone (3). The structures of the isolated compounds were established based on NMR and MS spectroscopic data. Disk diffusion method was employed to evaluate the antibacterial and antifungal activities of the isolated compounds against two bacterial and four fungal strains. The chloroform extract and the compounds demonstrated significant antibacterial activities. Compound 2 showed the highest activity against Staphylococccus aureus bacterial strain and Trichoderma spp fungal strain. Its antifungal activity (22 mm) against Trichoderma spp is even greater than that of the reference drug, clotrimazole (20 mm).

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“…In addition, quite recently, López et al 72 found cardamonin in a Polygonum, and the studies performed lead them to conclude that cardamonin has antifungal activity toward Epidermophyton floccosum (anthropophilic dermatophyte that can cause athlete's foot and onychomycosis among others), however, it did not show any noteworthy activity against other fungi like Candida albicans, Saccharomyces cerevisiae, or Cryptococcus neoformans. The antifungal evaluation was performed over cell lines of all the mentioned fungi in an agar dilution method.…”

Section: Anti-infectious Activitymentioning

confidence: 99%

An Overview on Cardamonin

Gonçalves

Valente

Rodrigues

2014

Journal of Medicinal Food

108

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Cardamonin, as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. In this study, research on cardamonin is reviewed, including its natural sources, health promoting aspects, and analytical methods for its determination. Therefore, this article hopes to aid current and future researchers on the search for reliable answers concerning cardamonin's value in medicine.

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Detection of antifungal compounds in Polygonum ferrugineum Wedd. extracts by bioassay-guided fractionation. Some evidences of their mode of action

Cited by 24 publications

References 17 publications

Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd

Antimicrobial Chalcones from the Seeds of Persicaria lapathifolia

An Overview on Cardamonin

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