2016
DOI: 10.5812/jjm.39285
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Detection of Antiseptic Resistance Genes among Staphylococcus aureus Colonising Nurses and Coagulase-Negative Staphylococci Isolated from Clinical Specimens at Teaching Hospitals in Southwest of Iran

Abstract: Background: The wide application of antibiotics and antiseptics for patient therapy and medical equipment and surfaces disinfection has resulted in the emergence of resistant microorganisms. Staphylococcus aureus and coagulase-negative Staphylococci (CoNS) are found as a part of the normal resident flora in human so that up to two-thirds of the healthy populations are permanently or transiently colonized by S. aureus and CoNS. Chlorhexidine is an antiseptic agent particularly effective against Gram-positive ba… Show more

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Cited by 8 publications
(15 citation statements)
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“…With respect to the evaluation of the susceptibility of chlorhexidine, we observed in the literature that the percentage varies greatly, depending on the region studied, as well as the detection of the qacA/B genes [26, 27]. Due to this variability of data and the poorly studied geographic distribution of these genes [3], it is important to monitor the resistance to antiseptics in our territory.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…With respect to the evaluation of the susceptibility of chlorhexidine, we observed in the literature that the percentage varies greatly, depending on the region studied, as well as the detection of the qacA/B genes [26, 27]. Due to this variability of data and the poorly studied geographic distribution of these genes [3], it is important to monitor the resistance to antiseptics in our territory.…”
Section: Discussionmentioning
confidence: 99%
“…Chlorhexidine susceptible strains carrying the qacA/B gene may be resistant to other antiseptics, which have not been tested in this study. The correlation between the presence of qacA/B and elevated MICs is still not fully understood and it has been demonstrated that the carriage of more than one determinants of resistance concomitantly in an isolate can increase the MIC of chlorhexidine [27].…”
Section: Discussionmentioning
confidence: 99%
“…The important virulence factors involved in the disease process can be divided into cell surface factors which recognize the adhesive matrix molecules (e.g., protein A, along with fibronectin-binding, collagenbinding, and clumping factor proteins), capsular polysaccharides, and staphyloxanthin, as well as secreted factors (e.g., superantigens, cytolytic toxins, and various exoenzymes and miscellaneous proteins) that play active roles in disarm host immunity (1,(31)(32)(33). According to previous studies (1,2,8), β-lactam antibiotics demonstrate the most optimal treatment for S. aureus infections and lead to the prominent cause of resistance such as MRSA. Furthermore, the mechanisms of antibiotic activity of the methicillin against S. aureus possibly act by the inhibitory effects of the PBPs that are involved in the synthesis of peptidoglycan, causing cell wall synthesis and thus halting cell growth (34).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, methicillin-resistant S. aureus (MRSA) is the major hospital-and community-acquired pathogen that develops multiple drug resistance to β-lactam antibiotics. MRSA isolates appear as a common cause of the disease and death and impose severe economic problems (3)(4)(5)(6)(7)(8).…”
Section: Introductionmentioning
confidence: 99%
“…Although qac genes (qacA/B and qacC) that provide resistance to quaternary ammonium compounds and derivative biocidal agents were first identified in human-induced Staphylococcus aureus and coagulase negative staphylococci, qacA/B and qacC resistance genes have also been reported in samples isolated from food and food production sites (Lyon & Skurray, 1987;Bjorland et al, 2003;Bischoff et al, 2012;Wendlant et al, 2013;Ebner et al, 2013;Monecke et al, 2013;Wassenaar et al, 2015;Damavandi et al, 2017;Ignak et al, 2017;Do Vale et al, 2019;Cantekin et al, 2019). These genes have often been reported as plasmid-borne genes.…”
Section: Introductionmentioning
confidence: 99%