Detection of atherosclerosis-associated HOCl using a mitochondria-targeted fluorescent probe

Targeted Imaging in Atherosclerosis

“…Most importantly, the probe was specifically accumulated in the endoplasmic reticulum and successfully used for fluorescence imaging of endogenous ClO – in foam cells. Additionally, a mitochondrial-targeted AS-ClO probe was also designed for the detection of HClO in foam cells (Figure D) . Upon an oxidizing reaction with HClO, AS-ClO displayed a dramatic fluorescence enhancement at 520 nm with excellent selectivity, low detection limit, and fast response.…”

A long-wavelength mitochondria-targeted CO fluorescent probe for living cells and zebrafish imaging

“…Among the many CO detection methods, uorescent probes have been widely developed due to their high selectivity, high sensitivity, and real-time imaging. [14][15][16][17][18][19][20][21][22] In 2012, Chang et al constructed the rst uorescent probe for imaging CO in living cells, and since then, the use of uorescent probes for the detection of CO in living cells or in vivo has been a hot topic of research. [23][24][25][26][27][28][29][30] In 2015, Dhara et al reported a novel way to detect CO using the Tsuji-Trost strategy.…”

A highly selective A–π–A “turn-on” fluorescent probe for hypochlorite in tap water

“…[3][4][5][6][7][8] Excessive intracellular ClO À as oxidative stressors may cause tissue damage in the human body and even harm human organs. 9,10 It has been demonstrated that many common diseases in humans, such as atherosclerosis, 11 diabetes 12 and cancer, 13 are related to the abnormal level of ClO À . In addition, sodium hypochlorite is commonly used in bleaching, treatment of industrial wastewater and sanitation.…”