Abstract:To develop an adequate animal model for atherosclerosis in large vessels of patients with diabetes, i.e. diabetic macroangiopathy, we induced diabetes in APA hamsters with a single injection of streptozotocin (SZ) and examined the aorta histopathologically and immunohistochemically. As a result, hyperglycemia and hyperlipidemia were continuously observed for 26 weeks after the SZ injection (WAI) in APA hamsters. Fatty streaks characterized by a subendothelial accumulation of many foam cells were observed, limited to the aortic arches as early as 6 WAI. In addition to larger fatty streaks developing with the duration of diabetes, fibrous plaques and plaques containing calcium deposits or cholesterol clefts developed at 26 WAI. These lesions are generally similar to the atheromatous lesions developed in humans. Moreover, depositions of apolipoprotein E and advanced glycation end-products immunohistochemically detected in the lesions were very similar to those found in humans. The diabetic APA hamster is therefore considered to be a useful model for studying the formation of atheromatous lesions in diabetic patients. Key words: APA hamster, atheromatous lesion, diabetes, macroangiopathy small vessels (microangiopathy) [19,23,33,35]. On the other hand, appropriate animal models of diabetic complications in large vessels (macroangiopathy) are quite rare [18,34], even though macroangiopathy is a leading cause of death in diabetic patients [7,10,29,38].Syrian hamsters of the APA strain (APA hamsters) have been developed in Japan [40] and are known to