Detection of autoantibodies against alpha-enolase (ENO1) as potential biomarkers improving immunodiagnosis in human osteosarcoma by serological proteome analysis.

Li, Jitian; Huang, Manyu; Guo, Zhiping; Teng, Junyan; Li, Wuyin; Zhang, Jianying

doi:10.1200/jco.2018.36.15_suppl.e23506

Cited by 1 publication

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“…Immunodiagnosis is a kind of diseases diagnosis which relies on the detection of immunological variations caused by disease development . The occurrence and development of diseases often bring about obvious changes in leukocyte population and certain protein expression levels in the peripheral blood . Detection of those variations as well as the intruding pathogens gives rise to a more convenient disease diagnosis.…”

Section: Immunodiagnosis Studies On Microfluidic Chipsmentioning

confidence: 99%

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Analysis of Leukocyte Behaviors on Microfluidic Chips

Yang

Cao

2019

Adv Healthcare Materials

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The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip–based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

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Section: Immunodiagnosis Studies On Microfluidic Chipsmentioning

confidence: 99%

“…Occurrence and development of diseases often induce a series of variations in leukocyte population, including certain subset concentration and functionality . Detection of these variations has provided massive information for clinical disease diagnosis.…”

Section: Immunodiagnosis Studies On Microfluidic Chipsmentioning

confidence: 99%

Analysis of Leukocyte Behaviors on Microfluidic Chips

Yang

Cao

2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

Detection of autoantibodies against alpha-enolase (ENO1) as potential biomarkers improving immunodiagnosis in human osteosarcoma by serological proteome analysis.

Cited by 1 publication

References 0 publications

Analysis of Leukocyte Behaviors on Microfluidic Chips

Analysis of Leukocyte Behaviors on Microfluidic Chips

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