Detection of bacteriuria among human immunodeficiency virus seropositive individuals in Osogbo, south-western Nigeria

Abstract

Human immunodeficiency virus-positive individuals are at increased risk of both asymptomatic and symptomatic urinary tract infections. The aim of this study was to determine the prevalence of asymptomatic bacteriuria (ASB) in HIV-positive individuals, its associated factors including any correlation with the CD4 count of the patient, and the antibiotic susceptibility pattern of the isolated organisms. Midstream urine and blood samples were collected from 242 consenting HIV-positive patients who were attending routine follow-up clinic during the six-month period of the study. Microscopy, culture, and antibiotic susceptibility testing of the samples were carried out following standard protocols, and CD4 counts were also determined. Fifty one (21.1%) of the 242 individuals had significant bacteriuria. The predominant organism was Klebsiella spp. (35%) followed by Escherichia coli (31%). Prevalence of bacteriuria was higher in the women. Low CD4 counts and young age were significantly associated with the presence of bacteriuria. ASB prevalence is high in this population and related to the CD4 count level.

Factors associated with urinary tract infections among HIV-1 infected patients

“…It has been observed that those with low lymphocyte CD4+ counts (<200 cell/μl) are at significantly higher risk of asymptomatic bacteriuria and are therefore more likely to develop urinary tract infection [ 3 ].…”

“…Urinary tract infections, both symptomatic and asymptomatic, are serious public healthcare problems decreasing the quality of life and leading to work absence [ 3 ].…”

Prevalence of Bacterial Urinary Tract Infections and Associated Factors among Patients Attending Hospitals in Bushenyi District, Uganda

“…Urinary tract infections may be asymptomatic, acute, chronic, and complicated or uncomplicated, and the clinical manifestations of UTIs depend on the portion of the urinary tract involved, the etiologic organisms, the severity of the infection, and the patient's ability to mount an immune response to it. Both asymptomatic and symptomatic UTIs pose a serious threat to public health care, hence reducing the quality of life and resulting into work absenteeism [7]. The symptoms of UTIs such as fever, burning sensations while urinating, LAP, itching, formation of blisters and ulcers in the genital area, genital and suprapubic pain, and pyuria generally depend on the age of the person infected and the location of the urinary tract infected [2].…”

Prevalence of Urinary Tract Infections and Associated Risk Factors Among Patients Attending Medical City Hospital in Baghdad City, Iraq

“…UTIs may occur either symptomatic or asymptomatic and the symptoms are either acute or chronic and may be uncomplicated or complicated. The clinical manifestation of urinary tract infections depends on; causative agent, severity of the bacterial infection and the ability to immune response (Olowe et al, 2015). Clinical symptoms of UTIs include; fever, burn during urinating, suprapubic pain and formation of blisters and ulcers in the genital area.…”