Detection of Bile Duct Leaks Using MR Cholangiography with Mangfodipir Trisodium (Teslascan)

Vitellas, Kenneth M.; El-Dieb, Adam; Vaswani, Kuldeep K.; Bennett, William F.; Fromkes, John J.; Steinberg, Steven M.; Bova, James G.

doi:10.1097/00004728-200101000-00019

Cited by 56 publications

(23 citation statements)

References 6 publications

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“…Clinical applications include the pre-operative evaluation of the biliary system of potential living-related liver donors, where the contrast-enhanced visualisation of the non-distended intrahepatic biliary ducts is a useful adjunct to the "classical" MRC technique [83]. Contrast-enhanced-cholangiography helps in the detection of biliary leakage after surgery, when T2w MRC fails to differentiate peribiliary retentions [84].…”

Section: Sequence Optimisation and Recommended Clinical Protocolsmentioning

confidence: 99%

Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications

2004

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Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd-EOB-DTPA, is under consideration. The purpose of this review is to provide an overview on the properties, clinical development and application of these three hepatobiliary contrast agents. Bolus injectable paramagnetic hepatobiliary contrast agents combine established features of extracellular agents with the advantages of hepatocyte specificity. The detection and characterisation of focal liver disease appears to be improved compared to unenhanced MRI, MRI with unspecific contrast agents and contrast-enhanced CT. To decrease the total time spent by a patient in the MR scanner, it is advisable to administer the agent immediately after acquisition of unenhanced T1-w MRI. After infusion or bolus injection (with dynamic FS-T1-w 2D or 3D GRE) of the contrast agent, moderately and heavily T2w images are acquired. Post-contrast T1-w MRI is started upon completion of T2-w MRI for mangafodipir trisodium and Gd-EOB-DTPA as early as 20 min following injection, while gadobenate dimeglumine scans are obtained >60 min following injection. Post-contrast acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by MSCT combined with an unparalleled improvement in tumour-liver contrast. The individual decision that hepatobiliary contrast agent one uses is partly based on personal preferences. No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other.

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Section: Sequence Optimisation and Recommended Clinical Protocolsmentioning

confidence: 99%

Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications

2004

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“…Laparoskopik kolesistektomide safra kaçaği siklikla sistik kanal güdüğünün kapatilamamasi veya safra kesesi yatağindan safra kesesini siyirirken Lushka kanalinin bütünlüğünün bozulmasi sonrasinda görülür [7]. Safra kaçaği varliğinda erken tani ve uygun tedavi hasta yönetiminde çok önemlidir.…”

Section: Discussionunclassified

Diagnosing the duct of Luschka injury at magnetic resonance imaging with hepatospecific contrast agents after laparoscopic cholecystectomy

Yılmaz¹,

Bulakçı²

2017

Pau Med J

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“…However, as explained earlier, the fact that bile drains are often not used reduces the incidence of this type of complication in patients who underwent OLT. Recent studies have evaluated CPMR in association with the endovenous contrast medium mangafodipir trisodium (Teslascan ® , Amersham Health) 34,35 . This consists of a manganese ion bonded to a vitamin B6 analog, which accumulates in the liver and is excreted through the bile duct.…”

Section: Viewing Of the Bile Ductsmentioning

confidence: 99%

Evaluation of the efficacy and reproducibility of cholangiopancreatography by magnetic resonance for detecting biliary complications following orthotopic liver transplantation

et al. 2010

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Purpose: To evaluate the accuracy and reproducibility of magnetic resonance cholangiopancreatography (MRCP) in the detection of biliary complications in liver transplanted patients. Methods: A study was conducted, with blinded review of 28 MRCP exams of 24 patients submitted to liver transplantation. The images were reviewed by two independent observers, at two different moments, regarding the degree of biliary tree visualization and the presence or absence of biliary complications. The MRCP results were compared, when negative, to at least 3 months of clinical and biochemical follow-up, and when positive, to the findings at surgery or endoscopic retrograde cholangiopancreatography (ERCP). Results: The degree of intrahepatic biliary tree visualization was considered good or excellent in 78.6% and 82.1% of the exams by the two observers and visualization of the donor duct, recipient duct and biliary anastomosis was considered good or excellent in 100% of the exams, by both observers. Six biliary complications were detected (21.4%), all of them anastomotic strictures. Intra and interobserver agreement were substantial or almost perfect (kappa k values of 0.611 to 0.804) for the visualization of the biliary tree and almost perfect (k values of 0.900 to 1.000) for the detection of biliary complications. MRCP achieved 100% sensitivity, 95.45% specificity, 85.7% positive predictive value and 100% negative predictive value for the detection of biliary complications. Conclusions: MRCP is an accurate examination for the detection of biliary complications after orthotopic liver transplantation and it is a highly reproducible method in the evaluation of the biliary tree of liver transplanted patients. Key words: Liver Transplantation. Magnetic Resonance Imaging. Bile Ducts. Cholangiography. RESUMOObjetivo: Medir a acurácia e reprodutibilidade da colangiopancreatografia por ressonância magnética (CPRM) na avaliação da visibilização de complicações biliares em pacientes submetidos a transplantes hepáticos ortotópicos. Métodos: Realizado estudo retrospectivo de 28 exames de CPRM de 24 pacientes submetidos a transplantes hepáticos. Os exames foram interpretados por dois observadores independentes, em dois momentos distintos, quanto ao grau de visibilização das estruturas estudadas e quanto à presença ou ausência de alterações nas vias biliares. Os resultados da CPRM foram comparados, nos casos de CPRM negativa, à evolução clínico-laboratorial por pelo menos 3 meses e, nos casos de CPRM alterada, aos achados de colangiopancreatografia retrógrada endoscópica (CPRE) e cirurgia, quando indicados. Resultados: A visibilização das vias biliares intra-hepáticas foi considerada boa ou excelente em 78,6% e 82,1% dos exames pelos dois observadores. A visibilização da via biliar extra-hepática do doador e do receptor, bem como da anastomose biliar, foi considerada boa ou excelente em 100% dos casos por ambos os observadores. Foram detectadas seis complicações biliares (21,4% dos casos), todas elas estenoses anastomóticas. A conco...

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Detection of Bile Duct Leaks Using MR Cholangiography with Mangfodipir Trisodium (Teslascan)

Cited by 56 publications

References 6 publications

Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications

Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications

Diagnosing the duct of Luschka injury at magnetic resonance imaging with hepatospecific contrast agents after laparoscopic cholecystectomy

Evaluation of the efficacy and reproducibility of cholangiopancreatography by magnetic resonance for detecting biliary complications following orthotopic liver transplantation

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