Detection of biochemical intermediates by mass fragmentography: Mescaline and tetrahydroisoquinoline precursors

Lindgren, Jan‐Erik; Agurell, Stig; Lundström, Jan O.; Svensson, U

doi:10.1016/0014-5793(71)80655-5

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…Six nitrogen containing compounds were detected in the alkaloid fraction obtained from A. belladonna cell cultures. According to their mass spectra the main constituents could be identified as N-methyl-2-pyrrolidinone (22), phenylethylamine, and tyramine (23). Tropane alkaloids were present in traces only.…”

Section: Alkaloids Of Cell Suspension Culturesmentioning

confidence: 99%

Reinvestigation of the Alkaloid Composition ofAtropa belladonnaPlants, Root Cultures, and Cell Suspension Cultures

et al. 1986

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The alkaloid composition of ATROPA BELLADONNA was analyzed by high resolution GLC and GLC-MS. A total of 13 alkaloids, most new for ATROPA, were identified from roots. The aboveground parts of the plant revealed 7 alkaloids; the hygrines were completely absent. The alkaloid pattern of root cultures was almost identical with the pattern of roots from intact plants. The patterns differed only quantitatively. Scopolamine which in A. BELLADONNA seems to be synthesized in the roots only, was preferably excreted into the culture medium. Norhyoscyamine was found frequently in plant shoots. The occurrence of hyoscyamine N-oxide in various plant organs could be confirmed. Cell suspension cultures produced trace amounts of hyoscyamine, 3alpha-acetoxytropane and 3alpha-tigloyloxytropane. The last two ester alkaloids were not detectable in intact plants.

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Section: Alkaloids Of Cell Suspension Culturesmentioning

confidence: 99%

Reinvestigation of the Alkaloid Composition ofAtropa belladonnaPlants, Root Cultures, and Cell Suspension Cultures

et al. 1986

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“…Around the same time, S. Agurell and colleagues, in Sweden, had also used GC-MS and mass fragmentography to identify drugs in various cases. , Applications included precursors of mescaline in Peyote cactus and various drugs in the blood of subjects who had recently smoked them. The New York Times reported on a presentation from their group in which a GC-MS assay for Δ 9 -THC in human blood was sensitive enough to detect if someone had smoked “one half-billionth of a gram.” (The original report used the name delta-1-THC, which is based on the monoterpene numbering system.…”

Section: Drugs and Toxicologymentioning

confidence: 99%

Forensic Mass Spectrometry: Scientific and Legal Precedents

Jackson

Barkett

2023

J. Am. Soc. Mass Spectrom.

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Mass spectrometry has made profound contributions to the criminal justice system by providing an instrumental method of analysis that delivers exquisite analytical figures of merit for a wide variety of samples and analytes. Applications include the characterization of trace metal impurities in hair and glass to the identification of drugs, explosives, polymers, and ignitable liquids. This review describes major historical developments and, where possible, relates the developed capabilities to casework and legal precedents. This review also provides insight into how historical applications have evolved into, and out of, modern consensus standards. Unlike many pattern-based techniques and physical-matching methods, mass spectrometry has strong scientific foundations and a long history of successful applications that have made it one of the most reliable and respected sources of scientific evidence in criminal and civil cases. That said, in several appellate decisions in which mass spectrometric evidence was challenged but admitted, decisions sometimes still went against the mass spectrometric data anyway, which goes to show that mass spectrometric evidence is always just one piece of the larger legal puzzle.

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The Simple Isoquinolines

Shamma

Moniot

1978

Isoquinoline Alkaloids Research 1972–1977

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Detection of biochemical intermediates by mass fragmentography: Mescaline and tetrahydroisoquinoline precursors

Cited by 10 publications

References 5 publications

Reinvestigation of the Alkaloid Composition ofAtropa belladonnaPlants, Root Cultures, and Cell Suspension Cultures

Reinvestigation of the Alkaloid Composition ofAtropa belladonnaPlants, Root Cultures, and Cell Suspension Cultures

Forensic Mass Spectrometry: Scientific and Legal Precedents

The Simple Isoquinolines

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