Detection of Bladder Urothelial Carcinoma Using In Vivo Noncontact, Ultraviolet Excited Autofluorescence Measurements Converted into Simple Color Coded Images: A Feasibility Study

Schäfauer, Christof; Ettori, Dominique; Rouprêt, Morgan; Phé, Véronique; Tualle, Jean-Michel; Tinet, Éric; Avrillier, Sigrid; Egrot, Christophe; Traxer, Olivier; Cussenot, Olivier

doi:10.1016/j.juro.2013.01.100

Cited by 26 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current standard methods for detecting BCa are cystoscopy and urine cytology [9]. Cystoscopy is a highly specific invasive procedure [10]. Although urine cytology is noninvasive and highly specific for detecting cancer cells, it lacks sensitivity, especially for low-grade malignancy [8].…”

mentioning

confidence: 99%

Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma

Lin

Wang

et al. 2019

Nephron

View full text Add to dashboard Cite

Background/Aims: human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) is highly expressed in multiple solid malignant tumors, making it a potential biomarker for tumorigenesis and invasion. However, the expression and clinical significance of HHLA2 in bladder urothelial carcinoma (BUC) have not been extensively studied. This study aimed to investigate the relationship between HHLA2 expression and clinicopathological characteristics of BUC. Methods: A total of 212 patients pathologically diagnosed with BUC were included in this study. HHLA2 expression was analyzed by immunohistochemical staining and qRT-polymerase chain reaction. Correlations of HHLA2 expression and pathological characteristics, including 5-year recurrence-free survival (RFS) and overall survival (OS) were examined, and the diagnostic value of HHLA2 was estimated by using the receiver operating characteristic (ROC) curve. Results: Immunohistochemical staining showed that the expression of HHLA2 was significantly upregulated in BUC tissues compared with normal bladder tissues. In BUC tissues, HHLA2 expression was significantly associated with tumor size, tumor stage, tumor grade, and lymph node metastasis (all p < 0.05). HHLA2 expression was an independent prognostic factor of tumor metastasis (p < 0.05). The Kaplan-Meier survival curve revealed that high HHLA2 expression was significantly correlated with the poor RFS and OS of BUC patients (both p < 0.05), and the ROC curve showed HHLA2 could be a good diagnostic marker. Conclusions: HHLA2 can independently predict unfavorable prognosis in BUC.

show abstract

mentioning

confidence: 99%

Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma

Lin

Wang

et al. 2019

Nephron

View full text Add to dashboard Cite

show abstract

“…SERS substrates can be conjugated to cancer-specific antibodies to enable multiplexed targeted imaging during endoscopy. [40]…”

Section: Raman Spectroscopy (Rs)mentioning

confidence: 99%

Emerging Endoscopic Imaging Technologies for Bladder Cancer Detection

Lopez

Liao

2014

Curr Urol Rep

View full text Add to dashboard Cite

Modern urologic endoscopy is the result of continuous innovations since early 19th century. White light cystoscopy is the primary strategy for identification, resection, and local staging of bladder cancer. While highly effective, white light cystoscopy has several well-recognized shortcomings. Recent advances in optical imaging technologies and device miniaturization hold the potential to improve bladder cancer diagnosis and resection. Photodynamic diagnosis and narrow band imaging are the first to enter the clinical arena. Confocal laser endomicroscopy, optical coherence tomography, Raman spectroscopy, UV autofluorescence, and others have shown promising clinical and pre-clinical feasibility. We review their mechanisms of action, highlight their respective advantages, and propose future directions.

show abstract

“…A recent pilot in vivo study compared spectroscopic results with histological findings in 14 patients who underwent cystoscopy. 59 Normal urothelium, papillary tumors and suspicious flat lesions were interrogated with a UV probe via the working channel of a standard cystoscope. The diagnostic signal was then converted into an intensity ratio of the emitted light at approximately 360 nm and 450 nm and color-coded to facilitate real-time interpretation.…”

Section: Introductionmentioning

confidence: 99%

“…The diagnostic signal was then converted into an intensity ratio of the emitted light at approximately 360 nm and 450 nm and color-coded to facilitate real-time interpretation. 59 Differentiation of bladder cancer from normal urothelium was demonstrated. Additional studies are required to investigate signal intensity across low- and high-grade bladder cancer, reproducibility, and potential for UV-induced toxicity.…”

Section: Introductionmentioning

confidence: 99%

Advances in Imaging Technologies in the Evaluation of High-Grade Bladder Cancer

Zlatev

Altobelli

Liao

2015

Urologic Clinics of North America

View full text Add to dashboard Cite

Bladder cancer is a heterogeneous disease that ranges from low-grade variant with an indolent course, to high-grade subtype with a recurrent, progressive, and potentially lethal outcome. Accurate assessment for individualized treatment depends critically on the diagnostic accuracy of white light cystoscopy. Despite its central role, white light cystoscopy has several well-documented shortcomings including difficult flat lesion detection, imprecise tumor delineation that limits complete resection, differentiation between inflammation and malignancy, and grade and stage determination. As the limitations of white light cystoscopy contribute to the risk of cancer persistence, recurrence, and progression, there is a need for improved visualization of flat, multifocal, high-grade, and muscle-invasive lesions. Optical imaging technologies have emerged as an adjunct to white light cystoscopy with the goal to guide more effective treatment by improving cancer detection and patient stratification on the basis of grade and stage. Photodynamic diagnosis and narrow band imaging are macroscopic imaging modalities similar to white light cystoscopy, but provide additional contrast enhancement of bladder tumors and have been shown to improve detection rates. Confocal laser endomicroscopy and optical coherence tomography are microscopic imaging technologies that enable real-time high resolution, subsurface tissue characterization with spatial resolutions similar to histology. Molecular imaging offers the potential for the combination of optical imaging technologies with cancer-specific molecular agents to improve the specificity of disease detection.

show abstract

Detection of Bladder Urothelial Carcinoma Using In Vivo Noncontact, Ultraviolet Excited Autofluorescence Measurements Converted into Simple Color Coded Images: A Feasibility Study

Abstract: This feasibility study confirms the functionality of our clinical prototype for the noncontact imaging detection of nonmuscle invasive bladder cancer via an endoscope using ultraviolet excited autofluorescence measurements.

Cited by 26 publications

References 21 publications

Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma

Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma

Emerging Endoscopic Imaging Technologies for Bladder Cancer Detection

Advances in Imaging Technologies in the Evaluation of High-Grade Bladder Cancer

Contact Info

Product

Resources

About