Detection of bone metastases in urogenital malignancies utilizing 99mTc-labeled phosphate compounds

Parthasarathy, K. L.; Landsberg, Ralph; Bakshi, Suraj P.; Donoghue, Glenda D.; Merrin, Claude

doi:10.1016/0090-4295(78)90217-0

Cited by 12 publications

(1 citation statement)

References 10 publications

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“…Bone imaging is widely used in the diagnosis and follow-up of many malignant conditions (McKillop and McDougall, 1980) and is of value in the assessment of urological tumours and their spread (Parthasarathy et al, 1978). Its value in the patient with carcinoma of the kidney is not clearly defined, although it has been suggested that scanning may be more sensitive than radiological survey (Cole et al, 1975).…”

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confidence: 99%

The Place of the ^99mTc‐polyphosphonate Bone Scan in Renal Carcinoma

Clyne

Frank

Jenkins

et al. 1983

British Journal of Urology

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mentioning

confidence: 99%

The Place of the ^99mTc‐polyphosphonate Bone Scan in Renal Carcinoma

Clyne

Frank

Jenkins

et al. 1983

British Journal of Urology

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Nuclear bone imaging in metastatic cancer of the prostate

Pollen

Gerber

Ashburn

et al. 1981

Cancer

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A reproducible technique of bone scanning in prostatic cancer is described that helps ensure the production of successive studies of highly comparable technical quality. Through an analysis of survival data based on changes in distribution, anatomic extent, and intensity of bone scan abnormalities in patients with advanced prostatic cancer, it is demonstrated that alterations in the appearance of the bone scan correlate closely with disease activity and have great prognostic significance.Cancer 47:2585-2594, 1981. ADLOISOTOPE B O N E SCANS are widely employedR for the early detection of skeletal metastasis from primary carcinoma of the Little attention has been directed to the use of serial nuclear bone imaging in the follow-up of metastatic cancer of the prostate after the initiation of A major barrier to the assessment of changes seen in serial scans has been the inability to produce scans of similar quality so that changes in disease activity can be distinguished from those caused by differences in technique or instrumentation. The purpose of this report is two-fold. First, a refined technique of bone scanning is described that helps ensure the production of successive scans that are of equal and comparable quality. When scans are performed using this technique, changes that occur in time on serial studies can be reliably attributed to alterations in disease activity rather than to differences in technique. Second, an attempt is made to validate that progression or regression of scan abnormalities do indeed accurately reflect progression or regression of metastatic disease by demonstrating that changes seen on serial scintigrams correlate highly with patient survival data.

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