Detection of Brain-Derived Cell-Free DNA in Plasma
Camilla Pellegrini,
Francesco Ravaioli,
Sara De Fanti
et al.
Abstract:Background: Neuronal loss is a major pathological feature of neurodegenerative diseases. The analysis of plasma cell-free DNA (cfDNA) is an emerging approach to track cell death events in a minimally invasive way and from inaccessible areas of the body, such as the brain. Previous studies showed that DNA methylation (DNAm) profiles can be used to map the tissue of origin of cfDNA and to identify molecules released from the brain upon cell death. The aim of the present study is to contribute to this research fi… Show more
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