Detection of cannabinoids in hair after cosmetic application of hemp oil

Paul, Richard; Williams, Robert; Hodson, V.; Peake, C.

doi:10.1038/s41598-019-39609-0

Cited by 20 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 105 Hair growth abnormalities include lack of hair growth (alopecia), and excessive hair growth (hirsutism and hypertrichosis). Given the success of topically applied compounds to treat hair loss 106 coupled with the detection of major cannabinoid compounds in hair fibers, including CBD, following cannabis consumption 107 and topical application of hemp oil 108 further understanding of how cannabinoid compounds can potentially benefit hair-related issues is needed. 109–111 …”

Section: Introductionmentioning

confidence: 99%

<p>Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders</p>

Baswan¹,

Klosner²,

Glynn³

et al. 2020

CCID

135

113

View full text Add to dashboard Cite

Though there is limited research confirming the purported topical benefits of cannabinoids, it is certain that cutaneous biology is modulated by the human endocannabinoid system (ECS). Receptors from the ECS have been identified in the skin and systemic abuse of synthetic cannabinoids, and their analogs, have also been associated with the manifestation of dermatological disorders, indicating the effects of the ECS on cutaneous biology. In particular, cannabidiol (CBD), a non-psychoactive compound from the cannabis plant, has garnered significant attention in recent years for its anecdotal therapeutic potential for various pathologies, including skin and cosmetic disorders. Though a body of preclinical evidence suggests topical application of CBD may be efficacious for some skin disorders, such as eczema, psoriasis, pruritis, and inflammatory conditions, confirmed clinical efficacy and elucidation of underlying molecular mechanisms have yet to be fully identified. This article provides an update on the advances in CBD research to date and the potential areas of future exploration.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders</p>

Baswan¹,

Klosner²,

Glynn³

et al. 2020

CCID

135

113

View full text Add to dashboard Cite

show abstract

“…A study in the UK showed that using hemp oil to cosmetically treat hair can lead to the absorption of THC, cannabidiol (CBD), cannabinol (CBN), and, on rare occasions, even the metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (THC-OH) [8]. This study also demonstrated that when volunteers applied hemp oil to their hair, 89% were found to have absorbed one or more constituents of cannabis, while 33% had absorbed the three major constituents, namely, CBD, THC, and CBN [8]. Moreover, in their study of (self-reported) heavy cannabis users, Taylor et al found that 77% had traces of THC in their hair, 73% had CBN, and 19% had CBD [17].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, hemp oil is offered on the market as a cosmetic hair treatment, with product manufacturers claiming that the direct application of the oil can moisturise and protect hair, promote hair growth, and repair damaged hair. Despite the lack of scientific evidence supporting these claims, numerous online outlets sell these products, which range in composition from pure hemp oil to shampoos and similar hair treatments containing lower concentrations of hemp oil [8].…”

Section: Introductionmentioning

confidence: 99%

Risk Assessment of Over-the-Counter Cannabinoid-Based Cosmetics: Legal and Regulatory Issues Governing the Safety of Cannabinoid-Based Cosmetics in the UAE

et al. 2021

View full text Add to dashboard Cite

Purpose: The lack of scientific evidence of the safety and efficacy of over-the-counter topical cannabinoid-based cosmetics remains a concern. The current study attempted to assess the quality of cannabinoid-based cosmetic products available on the UAE market. In particular, the study attempted to quantify the presence of undeclared tetrahydrocannabinol, specifically delta-9-tetrahydrocannabinol (THC) and delta-9-tetrahydrocannabinolic acid (THCA), in these products. Methods: A total of 18 cannabinoid-based cosmetics were collected and analysed in this study. GC-MS analysis was used to determine the presence of total undeclared tetrahydrocannabinol. Results: The estimate for the average tetrahydrocannabinol content was 0.011% with a 95% CI (0.004−0.019). Leave-on cosmetics products are more likely to contain total tetrahydrocannabinol compared to rinse-off cosmetics (p = 0.041). Although there was no statistically significant difference in the total tetrahydrocannabinol according to cosmetic category, there was a tendency towards higher tetrahydrocannabinol content in the hand care products, baby products, and body care preparations. Conclusion: The current study reveals the need for producers of cannabinoid-based cosmetic products to issue quality certificates for each batch produced to inform users of the tested levels of tetrahydrocannabinol.

show abstract

“…Furthermore, the cannabinoids cannabinol (CBN) and cannabidiol (CBD) are also analysed in hair analysis [9]. These substances are not psychoactive and are THC oxidation products.…”

Section: Current Status 21 Chemical Structure Of Cannabismentioning

confidence: 99%

Detectability of the Psychotropic Substance Cannabis in Head or Body Hair: Update of Forensic Criminalistics

Floren¹

2020

Digital Forensic Science

View full text Add to dashboard Cite

Cannabis is a substance known and used by humans for thousands of years. Both from China and India, very old written traditions are known, which prove the use of cannabis in medicine. From the USA, there are opinions of scientists, who attribute a much higher risk for a lethal overdose to prescription drugs than is possible at all by the consumption of cannabis. Estimates for the area of the Federal Republic of Germany assume approximately 85,000 deaths per year due to the use of drugs and their undesirable side effects. The legal view of cannabis use is, with a few exceptions, a worldwide ban. In order to be able to implement these legal norms, investigators make use of a wide variety of procedures to prove the use of psychotropic substances in a court of law. In addition to the classical methods of taking blood samples and/or urine samples, it has also been possible for some time to prove the use of cannabis by examining hair samples. Only for about 40 years have various methods for retrospective forensic protection been available to criminalistics. Investigators use the special characteristics of hair, as opposed to blood, sperm or saliva. The hair grows more or less continuously from the root and stores substances from the metabolism of the body. This makes it possible for investigators to investigate the use of cannabis depending on the length and condition of the hair. In addition, the analytical methods for hair matrix analysis are continuously being developed. Studies have also shown various possibilities for the incorporation and accumulation of THC and its metabolites, the main active substances of cannabis, in hair. In addition to the classical substances for the preservation of evidence, further approaches result from scientific findings regarding the forensic analysis of hair. The securing and examination of head hair has become a standard procedure in investigations. It represents only a minor intervention for the test person. In addition, the storage of hair does not make any special demands on the temperature as an example. This makes hair a good examination tool for many parties involved in the procedure. However, scientific findings show the possibilities, risks and dangers of focusing exclusively on hair. In addition to the use of body hair as an object of investigation for the reliable collection of data, body hair can open up new possibilities. However, scientific findings must not be disregarded here. Every investigator must be aware at all times that he may only carry out interventions on accused persons on the basis of the respective state standards. The courts, too, can only give fair judgements if the investigating authorities have secured evidence that is also based on current scientific findings. In addition to the biological processes involved Digital Forensic Science 2 in the storage of foreign substances in the hair matrix, it is also necessary to describe in detail the various variants of analysis and evaluation on the various hair samples. All investigators must be aware at all ti...

show abstract

Detection of cannabinoids in hair after cosmetic application of hemp oil

Cited by 20 publications

References 23 publications

<p>Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders</p>

<p>Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders</p>

Risk Assessment of Over-the-Counter Cannabinoid-Based Cosmetics: Legal and Regulatory Issues Governing the Safety of Cannabinoid-Based Cosmetics in the UAE

Detectability of the Psychotropic Substance Cannabis in Head or Body Hair: Update of Forensic Criminalistics

Contact Info

Product

Resources

About