2020
DOI: 10.3390/bios10060072
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Detection of Cardiovascular CRP Protein Biomarker Using a Novel Nanofibrous Substrate

Abstract: It is known that different diseases have characteristic biomarkers that are secreted very early on, even before the symptoms have developed. Before any kind of therapeutic approach can be used, it is necessary that such biomarkers be detected at a minimum concentration in the bodily fluids. Here, we report the fabrication of an interdigitated sensing device integrated with polyvinyl alcohol (PVA) nanofibers and carbon nanotubes (CNT) for the detection of an inflammatory biomarker, C-reactive protein (CRP). The… Show more

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Cited by 14 publications
(13 citation statements)
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“…As compared to rigid biosensors, 11,61,67 tattoo biosensors require fewer raw materials for mass production, are easier to transport, lighter, and thinner. It is not possible to incorporate commercial SPEs 7,20,65,114 into wearable devices due to the requirement for a relatively large connector. Moreover, tattoo sensors are suitable for monitoring sweat CRP levels in real time without the need for the collection of body fluids; however, portable SPEs and paper electrodes 63 are not suitable for collecting body fluids.…”
Section: Resultsmentioning
confidence: 99%
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“…As compared to rigid biosensors, 11,61,67 tattoo biosensors require fewer raw materials for mass production, are easier to transport, lighter, and thinner. It is not possible to incorporate commercial SPEs 7,20,65,114 into wearable devices due to the requirement for a relatively large connector. Moreover, tattoo sensors are suitable for monitoring sweat CRP levels in real time without the need for the collection of body fluids; however, portable SPEs and paper electrodes 63 are not suitable for collecting body fluids.…”
Section: Resultsmentioning
confidence: 99%
“…2,3 Among all biomarkers for COPD, Creactive protein (CRP) is the most selective biomarker for predicting acute exacerbations of the disease. [4][5][6] Moreover, high levels of CRP in the blood are proven to be associated with some other diseases such as heart failure, 7 sepsis, 8 and inflammatory bowel diseases [9][10][11] such as Crohn's disease, ulcerative colitis, and colon cancer. 12 For instance, CRP concentrations higher than 3 mg l −1 indicate a high risk of acute respiratory exacerbation, while concentrations lower than 1 mg l −1 and within 1-3 mg l −1 suggest a low and moderate risk, respectively.…”
mentioning
confidence: 99%
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“…EIS offers a highly sensitive and selective technique for most bio-sensor studies involving large biomolecules, such as proteins [ 45 , 46 , 47 ]. The detection principle works on measuring changes of electrochemical signals such as charge transfer [ 48 , 49 ], capacitance [ 50 ] or impedance [ 51 , 52 ]. Binding between Ank GAG 1D4 and CA was detected as changes in electrochemical signals such as peak current and charge transfer resistivity were observed ( Figure 5 ).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, CRP is commonly used as an important indicator, assisting in the diagnosis and treatment monitoring of sepsis. In addition, CRP has been widely used as a non-specific biomarker for inflammation and tissue damage, such as cardiovascular diseases, in clinical medicine [5][6][7]. The American Heart Association (AHA) and the Centers for Disease Control and Prevention (CDC) use serum CRP levels to assess the risk level of cardiovascular diseases.…”
Section: Introductionmentioning
confidence: 99%