Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI

Rotta, Johanna; Perosa, Valentina; Yakupov, Renat; Kuijf, Hugo J.; Schreiber, Frank; Dobisch, Laura; Oltmer, Jan; Assmann, Anne; Speck, Oliver; Heinze, Hans‐Jochen; Acosta‐Cabronero, Julio; Düzel, Emrah; Schreiber, Stefanie

doi:10.1212/wnl.0000000000011790

Cited by 20 publications

(22 citation statements)

References 51 publications

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“…Blood-brain barrier failure due to venous collagenosis and leakage of venules has been considered one of the mechanisms of CMB (26,29). A recent study focused on detecting CMBs of venous connections using quantitative susceptibility mapping (QSM) with 7-T MRI (30), which could be applied to explore CMBs of DMV origin.…”

Section: Discussionmentioning

confidence: 99%

Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease

Yin¹,

Han²,

Cao³

et al. 2023

Quant Imaging Med Surg

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Background: This study aimed to explore the association between deep medullary veins (DMVs) and the neuroimaging burden of cerebral small vessel disease (CSVD). Methods:In this cross-sectional study based on a retrospective analysis, a total of 248 patients (183 males and 65 females; mean age ± standard deviation, 69.5±14.8 years) diagnosed with CSVD with complete imaging and clinical data were enrolled. Neuroimaging markers of CSVD, including white matter hyperintensities, lacunes, prominent perivascular spaces (PVSs), and cerebral microbleeds (CMBs), were identified, and the total burden of CSVD was scored. Both DMV number and DMV score were used for assessment using susceptibility-weighted imaging (SWI).Results: With the exception of perivascular spaces, more severe neuroimaging markers were observed in patients with a higher DMV score. After adjustments were made for age and body mass index (BMI), a higher DMV score (β=1.39; P<0.001) and smaller DMV number (β=-2.55; P=0.001) were associated with an increased CSVD burden. The degree of CMBs was independently correlated with both DMV score (β=1.60; P<0.001) and DMV number (β=-2.27; P=0.009). The association between lacunes and DMV score was also significant (β=0.97; P=0.026).Conclusions: Both DMV score and DMV number are potential imaging indicators of CSVD.

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Section: Discussionmentioning

confidence: 99%

Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease

Yin¹,

Han²,

Cao³

et al. 2023

Quant Imaging Med Surg

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“…As previously explained in another study by our group ( 25 ), the T2 * -w magnitude and phase data underwent reconstruction steps, in order to produce QSM maps. Multiple-channel complex image data were combined using an adaptive algorithm ( 26 ) followed by automatic reference channel selection.…”

Section: Methodsmentioning

confidence: 99%

Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease

Perosa

Rotta²,

Yakupov³

et al. 2023

Front. Neurol.

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BackgroundCerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2*-weighted sequences on MRI. Quantitative susceptibility mapping (QSM) is a postprocessing method that also enables MBs identification and furthermore allows to differentiate them from calcifications.AimsWe explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD.MethodsBoth 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2*-weighted imaging and QSM. Differences in the number of MBs were assessed, and subjects were classified in CSVD subgroups or controls both on 3T T2*-weighted imaging and 7T QSM.Results48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn7T−QSM = 2.5; Mdn3T−T2 = 0; z = 4.90; p < 0.001) and false positive MBs (6.1% calcifications), most healthy controls (80.6%) demonstrated at least one MB and more MBs were discovered in the CSVD group.ConclusionsOur observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed.

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“…CMHs were reported to contribute to the pathogenesis of cognitive decline [159,[184][185][186][187][188][189][190][191][192]. In addition to the well-characterized arteriolar origin of CMHs, there is emerging evidence that CMHs can also originate from the rupturing of small veins, venules, and capillaries [159,[193][194][195]. Studies linking the development of CMHs to the performance of Valsalva maneuvers [196] support this concept.…”

Section: Role Of Veins In Vascular Cognitive Impairment In Agingmentioning

confidence: 99%

The aging venous system: from varicosities to vascular cognitive impairment

et al. 2021

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Aging-induced pathological alterations of the circulatory system play a critical role in morbidity and mortality of older adults. While the importance of cellular and molecular mechanisms of arterial aging for increased cardiovascular risk in older adults is increasingly appreciated, aging processes of veins are much less studied and understood than those of arteries. In this review, age-related cellular and morphological alterations in the venous system are presented. Similarities and dissimilarities between arterial and venous aging are highlighted, and shared molecular mechanisms of arterial and venous aging are considered. The pathogenesis of venous diseases affecting older adults, including varicose veins, chronic venous insufficiency, and deep vein thrombosis, is discussed, and the potential contribution of venous pathologies to the onset of vascular cognitive impairment and neurodegenerative diseases is emphasized. It is our hope that a greater appreciation of the cellular and molecular processes of vascular aging will stimulate further investigation into strategies aimed at preventing or retarding age-related venous pathologies.

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Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI

Cited by 20 publications

References 51 publications

Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease

Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease

Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease

The aging venous system: from varicosities to vascular cognitive impairment

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