Detection of Cholecystokinin B/Gastrin Receptor mRNA Expressing Cells in the Stomach of Hypergastrinemic Rats.

Kawasaki, Chihiro; Fujimura, Masaki; Mori, Atsumi; Hattori, Takanori

doi:10.1267/ahc.28.323

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Morphologically, they have been localized, by immunohistochemistry using a specific CCK-B antiserum, on parietal cells, chief cells, and some endocrine cells in the gastric mucosa of guineapig (Tarasova et al, 1996). By in situ hybridization, these receptors have been identified on the parietal, chief, ECL cells, and some proliferative cells in the gastric mucosa of normal or hypergastrinemic rats (Kawasaki et al, 1995;Waki et al, 1998). Recently, two other groups localized CCK-B receptors to parietal cells of the human stomach, by the use of autoradiography after gastrin-binding studies (Praissman et al, 1998;Reubi et al, 1997).…”

Section: Cck B/gastrin Receptorsmentioning

confidence: 99%

Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy: Role of gastrin and atrophying gastritis

Lehy

Roucayrol²,

Mignon

2000

Microsc. Res. Tech.

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Section: Cck B/gastrin Receptorsmentioning

confidence: 99%

Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy: Role of gastrin and atrophying gastritis

Lehy

Roucayrol²,

Mignon

2000

Microsc. Res. Tech.

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Effects of gastrin on the histamine‐secretory and proliferative activity of cultured carcinoid cells derived from the stomach of the rodent Mastomys natalensis

Takeno

Daa

Shimoda

et al. 1997

Pathology International

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The effects of gastrin on the synthesis and release of histamine and on cellular proliferation were investigated in a homotransplantable carcinoid tumor implanted in the rodent Mastomys natalensis and in cultured cells derived from the tumor. The homotransplanted tumor was immunopositive for histamine, synaptophysin and protein gene product 9.5, and its cells contained numerous secretory granules that were visualized by electron microscopy. When carcinoid cells were cultured in a medium with a high concentration of gastrin-I (10(4) pg/mL) for 7 days, large electron-dense secretory granules were characteristically observed in the cytoplasm. By contrast, only a few such granules and numerous secondary lysosomes were seen in cells that had been cultured in the same medium without gastrin-I. A high concentration of gastrin-I (10(4) pg/mL) significantly increased the release of histamine into the culture medium from the carcinoid cells compared with the control (P < 0.05). Cellular proliferation, as determined by monitoring the incorporation of [methyl-3H]-thymidine into the carcinoid cells increased significantly at lower concentrations of gastrin-I (10(2) and 10(3) pg/mL), (P < 0.05). At higher concentrations (10(4) pg/mL or more), gastrin-I had no effect on proliferation. These findings indicate that gastrin stimulates the synthesis and release of histamine by carcinoid cells, as well as their proliferation.

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Detection of Cholecystokinin B/Gastrin Receptor mRNA Expressing Cells in the Stomach of Hypergastrinemic Rats.

Cited by 2 publications

References 33 publications

Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy: Role of gastrin and atrophying gastritis

Histomorphological characteristics of gastric mucosa in patients with Zollinger-Ellison syndrome or autoimmune gastric atrophy: Role of gastrin and atrophying gastritis

Effects of gastrin on the histamine‐secretory and proliferative activity of cultured carcinoid cells derived from the stomach of the rodent Mastomys natalensis

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