Detection of Chronic Kidney Disease in Patients With or at Increased Risk of Cardiovascular Disease

Brosius, Frank C.; Hostetter, Thomas H.; Kelepouris, Ellie; Mitsnefes, Mark; Moe, Sharon M.; Moore, Michael A.; Pennathur, Subramaniam; Smith, Grace L.; Wilson, Peter W.F.

doi:10.1161/circulationaha.106.177321

Cited by 287 publications

(138 citation statements)

References 31 publications

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“…11 At the time of the initiation of this study, 400 GPs were considered up to standard and only their patients were the subjects of this study. We selected all the living subjects on 31 12 Prescriptions (at least one in the last 4 months) of the CV drugs were also examined.…”

Section: Methodsmentioning

confidence: 99%

Blood pressure control and drug therapy in patients with diagnosed hypertension: a survey in Italian general practice

Filippi

Paolini

Innocenti³

et al. 2009

J Hum Hypertens

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Blood pressure (BP) control remains unsatisfactory worldwide. Better knowledge of BP management in clinical practice is needed to develop more effective improving strategies. Using a large Italian primary care database, we selected the subjects diagnosed with hypertension, and extracted the diagnosis of myocardial infarction, angina pectoris/coronary disease, stroke/transitory ischemic attack (TIA), heart failure, atrial fibrillation, peripheral arterial disease, diabetes mellitus, the serum total cholesterol, HDL cholesterol, triglycerides, creatinine, BP, electrocardiogram, weight, height and the prescription of cardiovascular (CV)

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Section: Methodsmentioning

confidence: 99%

Blood pressure control and drug therapy in patients with diagnosed hypertension: a survey in Italian general practice

Filippi

Paolini

Innocenti³

et al. 2009

J Hum Hypertens

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“…In other cases, data were obtained from a specific questionnaire that was systematically asked of clinicians who sent a DNA sample. GFR was estimated using the Modification of Diet in Renal Disease equation (16) or the Schwartz formula for children (17). Data on renal function evolution were collected until last follow-up available or estimated GFR Ͻ10 ml/min per 1.73 m 2 .…”

Section: Study Populationmentioning

confidence: 99%

Phenotype and Outcome in Hereditary Tubulointerstitial Nephritis Secondary to UMOD Mutations

Bollée¹,

Dahan²,

Flamant³

et al. 2011

Clinical Journal of the American Society of Nephrology

116

134

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SummaryBackground UMOD mutations cause familial juvenile hyperuricemic nephropathy (FJHN) and medullary cystic kidney disease (MCKD), although these phenotypes are nonspecific.Design, setting, participants, & measurements We reviewed cases of UMOD mutations diagnosed in the genetic laboratories of Necker Hospital (Paris, France) and of Université Catholique de Louvain (Brussels, Belgium). We also analyzed patients with MCKD/FJHN but no UMOD mutation. To determine thresholds for hyperuricemia and uric-acid excretion fraction (UAEF) according to GFR, these parameters were analyzed in 1097 patients with various renal diseases and renal function levels.Results Thirty-seven distinct UMOD mutations were found in 109 patients from 45 families, all in exon 4 or 5 except for three novel mutations in exon 8. Median renal survival was 54 years. The type of mutation had a modest effect on renal survival, and intrafamilial variability was high. Detailed data available in 70 patients showed renal cysts in 24 (34.3%) of nonspecific localization in most patients. Uricemia was Ͼ75th percentile in 31 (71.4%) of 42 patients not under dialysis or allopurinol therapy. UAEF (n ϭ 27) was Ͻ75th percentile in 70.4%. Among 136 probands with MCKD/FJHN phenotype, UMOD mutation was found in 24 (17.8%). Phenotype was not accurately predictive of UMOD mutation. Six probands had HNF1B mutations.Conclusions Hyperuricemia disproportionate to renal function represents the hallmark of renal disease caused by UMOD mutation. Renal survival is highly variable in patients with UMOD mutation. Our data also add novel insights into the interpretation of uricemia and UAEF in patients with chronic kidney diseases.

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“…The incidence of contrast-induced AKI is low (2%) in the general population, 4 but it is higher in certain at-risk 7 and diabetes mellitus are at highest risk [8][9][10] ; the incidence of contrast-induced AKI is as high as 50% for patients with multiple risk factors. 11 Contrast-induced AKI has serious prognostic implications; it is linked to increases in length of hospital stay and to higher rates of in-hospital cardiovascular events, inhospital mortality, and 1-year and 5-year mortality rates.…”

Section: Contrast-inducedmentioning

confidence: 99%

Contrast-Induced Acute Kidney Injury: Specialty-Specific Protocols for Interventional Radiology, Diagnostic Computed Tomography Radiology, and Interventional Cardiology

Goldfarb

McCullough

McDermott

et al. 2009

Mayo Clinic Proceedings

139

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Contrast-induced acute kidney injury (AKI) (also known as contrast-induced nephropathy) is an abrupt deterioration in renal function that can be associated with use of iodinated contrast medium. Although the increase in serum creatinine concentration is transient in most cases, contrast-induced AKI may lead to increased morbidity and mortality rates in selected at-risk populations. This review summarizes the findings of a multidisciplinary panel composed of computed tomography radiologists, interventional radiologists, cardiologists, and nephrologists convened to address the specialty-specific issues associated with minimizing the incidence of contrast-induced AKI. As part of this initiative, the panel developed specialty-specific protocols for preventing contrast-induced AKI, taking into account, for example, the variations in patient risk profile, inpatient or outpatient status, and staffing resources that characterize various clinical settings. The 3 protocols, each reflecting a consensus of expert opinion, address the prevention of contrast-induced AKI in interventional radiology, diagnostic computed tomography radiology, and interventional cardiology settings. The protocols are presented in the context of a review of recent guidelines and published reports of trials that discuss contrast-induced AKI and its prevention. © 2009 Mayo Foundation for Medical Education and ResearchA cute kidney injury (AKI) is a heterogeneous disorder with multiple etiologies, risk factors, and clinical presentations. Although patients with AKI are ultimately cared for by nephrologists, AKI occurs in various clinical settings and is associated with a specific etiology in each. The term contrast-induced AKI refers to the disorder as it occurs after exposure to iodinated contrast media, a disorder that has been more commonly known as contrastinduced nephropathy (CIN). The Acute Kidney Injury Network, recognizing the need for improving outcomes associated with the various forms of AKI, recently proposed using the following standardized diagnostic definition in all cases: an abrupt (within 48 hours) reduction in kidney function, evidenced by an increase in the serum creatinine concentration of at least 0.3 mg/dL (to convert to µmol/L, multiply by 88.4) or at least 50% from baseline or a reduction in urine output (documented oliguria of <0.5 mL/kg/h for >6 hours).1,2 The criterion of oliguria does not apply for many cases of contrast-induced AKI because patients are treated with intravenous fluids before and after the procedure with the goal of increasing periprocedural urine output. The most commonly used definition of CIN is an increase from the baseline serum creatinine concentration of at least 0.5 mg/dL or at least 25% within 48 to 72 hours after exposure to contrast media. [3][4][5] Because the medical community is moving to adopt the concept and terminology of the American College of Radiology (ACR) in reference to studies of contrast-induced renal dysfunction and its prevention, 6 this report will do the same. However, we rec...

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Detection of Chronic Kidney Disease in Patients With or at Increased Risk of Cardiovascular Disease

Cited by 287 publications

References 31 publications

Blood pressure control and drug therapy in patients with diagnosed hypertension: a survey in Italian general practice

Blood pressure control and drug therapy in patients with diagnosed hypertension: a survey in Italian general practice

Phenotype and Outcome in Hereditary Tubulointerstitial Nephritis Secondary to UMOD Mutations

Contrast-Induced Acute Kidney Injury: Specialty-Specific Protocols for Interventional Radiology, Diagnostic Computed Tomography Radiology, and Interventional Cardiology

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