Detection of circulating tumor cells in non-small cell lung cancer

Hamilton, Gerhard; Rath, Barbara H.

doi:10.21037/jtd.2016.03.86

Cited by 22 publications

(23 citation statements)

References 24 publications

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“…For example, Chang et al (30), reported that tumor marker detection could complement CTC enumeration in predicting progression in patients with metastatic castration-resistant prostate cancer. The basic biological mechanisms of CTCs in facilitating cancer development and metastasis have attracted much attention (31,32). It is of great importance that highly specific molecular markers for CTC-targeted cancer therapy are identified.…”

Section: Discussionmentioning

confidence: 99%

ROR1 is highly expressed in circulating tumor cells and promotes invasion of pancreatic cancer

Shen

et al. 2018

Mol Med Report

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Pancreatic cancer (PaC) is an aggressive malignancy, which is associated with high levels of metastasis. Circulating tumor cells (CTCs), which may be considered a functional biomarker and promising treatment strategy for metastasis, are associated with the prognosis and progression of various metastatic cancers, including PaC. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expression contributes to cell metastasis and poor clinical outcomes in malignant tumors. The present study aimed to explore the function of ROR1 in PaC CTCs. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to examine the expression of ROR1, E-cadherin and N-cadherin. Cell proliferative and invasive ability was assessed by MTT and Transwell assays, respectively. The results revealed that the mRNA and protein expression levels of ROR1 were augmented in PaC tissues. Furthermore, the mRNA expression levels of ROR1 were higher in CTCs compared with in peripheral blood cells, and ROR1 was more highly expressed in CTCs than in cells. Notably, CTCs exhibited a markedly greater proliferative and invasive capacity than PANC-1 and SW-1990 cells, whereas knockdown of endogenous ROR1 by small interfering RNA led to suppression of the invasion of CTCs. In addition, it was revealed that the mechanism underlying the effects of ROR1 on PaC CTC metastasis may involve the epithelial-mesenchymal transition process. In conclusion, ROR1 may be considered a potential biomarker and therapeutic target for the treatment of PaC.

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Section: Discussionmentioning

confidence: 99%

ROR1 is highly expressed in circulating tumor cells and promotes invasion of pancreatic cancer

Shen

et al. 2018

Mol Med Report

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“…Mode of screening was defined as the personal experience of someone being screened, that is, what they have to undergo to be screened. The levels for this attribute were "lie in scanner," "sustained breath into device," and "give blood," corresponding to LDCT, breath analysis, and blood-based screening [29][30][31]. Finally, location of screening is where screening takes place and could be either "at nearest hospital" or "at your general practitioner's office."…”

Section: Interviews and Panel Session To Establish Attributes And Levelsmentioning

confidence: 99%

Public Preferences for Lung Cancer Screening Policies

et al. 2017

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“…About 80% of lung cancers are classified as NSCLC, 15% are small cell lung cancer (SCLC), and 5% are other histological variants (14). Current therapeutic options are chemotherapy and drug therapy directed against specific molecular targets, mainly epidermal growth factor receptor (EGFR) missense mutations and deletions, and anaplastic lymphoma kinase (ALK) rearrangements.…”

Section: Review Articlementioning

confidence: 99%