2024
DOI: 10.1038/s41598-024-61034-1
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Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry

Arata Ishii,
Shokichi Tsukamoto,
Naoya Mimura
et al.

Abstract: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasma cell (PC) dyscrasia. Detection of monoclonal PCs is mandatory for the diagnosis of POEMS syndrome; however, the usefulness of EuroFlow-based next-generation flow cytometry (EuroFlow-NGF) in POEMS syndrome for detecting monoclonal PCs in bone marrow (BM) and the gating strategy suitable for flow cytometry study o… Show more

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