Detection of cocaine and metabolites from mouse femur buried in soil

Nakao, Kenzo; Tatara, Yuki; Kibayashi, Kazuhiko

doi:10.1016/j.legalmed.2018.11.005

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Previous studies have examined drug concentrations in bones and have shown that they tend to be higher in bones than in blood [8,9,11,23]. One reason why drugs can be present in the bone is due to structural factors.…”

Section: Ta B L E 2 Intra-and Interday Precisionmentioning

confidence: 99%

“…Kojima et al [7] showed that methamphetamine and amphetamine were detected in the femur from a skeletonized corpse buried for 5 years. It has been shown that methamphetamine, amphetamine, cocaine, and their metabolites could be detected in mouse femurs buried in humus for 180 days [8, 9]. The reason why the drug was detected in bones that had been left for a long period of time could be attributed to the structural characteristics of the bones.…”

Section: Introductionmentioning

confidence: 99%

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Detection of methamphetamine in mouse femurs exposed to high temperature

Nakao

Kibayashi

2023

Journal of Forensic Sciences

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Bone samples are valuable for examining the cause of death and circumstance leading up to death when body fluids are not available for forensic toxicological analysis. Examined were heat‐induced changes in methamphetamine and amphetamine concentrations in femurs removed from methamphetamine‐injected mice to determine if the burned bones could be used for toxicology testing. The femurs were heated at 100°C, 300°C, or 500°C for 10 or 30 min. The tissue structure of the heated femurs was preserved at 100°C for 30 min but was destructed at higher temperatures. Methamphetamine and amphetamine were detected in femurs heated at 100°C for 10 min, 100°C for 30 min, and 300°C for 10 min (with methamphetamine and amphetamine concentrations ranging from 0.36 to 35 μg/g and 0.54 to 47 μg/g, respectively). Methamphetamine and amphetamine were detectable when heated above their decomposition temperature as a result of limited heat transfer do to protection provide by the femoral muscle. Thus, the bone could be a useful analytical sample in cases of burn‐related deaths, where it is difficult to collect body fluids.

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Section: Ta B L E 2 Intra-and Interday Precisionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of methamphetamine in mouse femurs exposed to high temperature

Nakao

Kibayashi

2023

Journal of Forensic Sciences

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Comparing Hard Tissues from Teeth or Bones as Potential Samples to Estimate Blood Drug Concentrations in Corpses Using a Rat-Model

Ichioka,

Yamamoto,

Kawamoto

et al. 2023

Preprint

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Toxicological Advancements in Cocaine Detection: A Review

Salerno

Patanè

Maglitto

et al. 2023

CMC

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Cocaine, also known as methyl benzoylecgonine, is one of the most used drugs of abuse and one of the oldest; however, there has been a recent increase in the consumption of this substance. This trend has once again caught the attention of the scientific community. We discuss the current knowledge about this drug, focusing our attention on the forensic approach. Despite the fact that the cut-off of positivity to cocaine in drug tests is quite high, most current tests are able to detect much lower concentrations and could improve forensic sciences in both post-mortem investigations and in people screening. Immunological assays possessing substantial cross-reactivity to cocaine are particularly useful for screening oral fluid, hair, and post-mortem blood, where significant concentrations of the drug can be found. Liquid chromatography has now supplanted the previous techniques because it is very sensitive and specific and allows samples to be analyzed in a shorter time with only minimal sample preparation. Recent studies have focused on increased sensitivity, reduced processing times, and cheaper analysis.

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Detection of cocaine and metabolites from mouse femur buried in soil

Cited by 3 publications

References 20 publications

Detection of methamphetamine in mouse femurs exposed to high temperature

Detection of methamphetamine in mouse femurs exposed to high temperature

Comparing Hard Tissues from Teeth or Bones as Potential Samples to Estimate Blood Drug Concentrations in Corpses Using a Rat-Model

Toxicological Advancements in Cocaine Detection: A Review

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