Detection of defects in myocardial perfusion imaging in patients with early breast cancer treated with radiotherapy

Seddon, Beatrice; Cook, Audrey; Gothard, Lone; Salmon, Emma; Latus, K. A.; Underwood, S. Richard; Yarnold, John

doi:10.1016/s0167-8140(02)00133-0

Cited by 121 publications

(70 citation statements)

References 33 publications

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“…A clinical study using SPECT or PET imaging of micro-vascular perfusion demonstrated perfusion defects already within 6e12 months after breast cancer radiotherapy [34]. However, no clinically significant differences in perfusion defects, summed stress defect scores and ejection fraction (EF) changes were found in 32 women with node-positive left-sided breast cancer after radiotherapy, with the mean heart dose < 5 Gy [35].…”

Section: Imaging Studies Cardiovascular Biomarkers and Radiotherapymentioning

confidence: 99%

Ionizing radiation and atherosclerosis: Current knowledge and future challenges

2013

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Section: Imaging Studies Cardiovascular Biomarkers and Radiotherapymentioning

confidence: 99%

Ionizing radiation and atherosclerosis: Current knowledge and future challenges

2013

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“…The damaged area is then replaced by fibrous tissue. Macrovascular damage results from injury to larger vessels, leading to exacerbation of atherosclerotic lesion formation (Seddon et al, 2002). The most important functional consequence is diffuse interstitial myocardial fibrosis, which contributes primarily to diastolic dysfunction (Gagliardi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer?

et al. 2009

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Background: Overall, ∼5% of patients show late normal-tissue damage after radiotherapy with a smaller number having a risk of radiation-induced heart disease. Although the data are conflicting, large studies have shown increased risks of cardiovascular disease (CVD) for irradiated patients compared with non-irradiated ones, or for those treated to the left breast or chest wall compared with those treated to the right. Cutaneous telangiectasiae as late normal-tissue injury have so far only been regarded as a cosmetic burden. Methods: The relationship between late normal-tissue radiation injury phenotypes in 149 irradiated breast cancer patients and the presence of cardiovascular disease were examined. Results: A statistically significant association between the presence of skin telangiectasiae and the long-term risk of CVD was shown in these patients ( P =0.017; Fisher's exact test). Interpretation: This association may represent initial evidence that telangiectasiae can be used as a marker of future radiation-induced cardiac complications. It could also suggest a common biological pathway for the development of both telangiectasiae and CVD on the basis of a genetically predisposed endothelium. To our knowledge this is the first reported study looking at this association.

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“…W kolejnym badaniu, również na podstawie SPECT, zaburzenia perfuzji (zarówno odwracalne jak i nieodwracalne) były wykrywne jeszcze po 5 latach u 71% pacjentek; większość z nich w obrębie koniuszka serca. Również tutaj nieznane jest znaczenie kliniczne tego zjawiska [10]. W niedawno opublikowanym szwedzkim badaniu wykazano z kolei, że istnieje bezpośredni związek pomiędzy radioterapią a konkretną lokalizacją zwężenia w tętnicach wieńcowych (np.…”

Section: Patofizjologiaunclassified

Problem kardiotoksyczności radioterapii raka piersi

Adamska

2017

LOS

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StreszczenieRak piersi rozpoznawany jest rocznie u ponad miliona kobiet na świecie. Zgodnie z obecnym standardem wiele z nich otrzyma złożone, wielodyscyplinarne leczenie, którego nieodłącznym elementem pozostaje radioterapia. Promieniowanie jonizujące jest znanym czynnikiem uszkadzającym serce. Wykazano, że popromienna choroba serca (RRHD -radiation-related heart disease ) może wystąpić już po dawkach < 20Gy i ujawnić się dopiero po dłuższym okresie latencji, zwykle przekraczającym dekadę. Wielkość ryzyka RRHD wciąż nie jest dobrze poznana, wydaje się jednak, iż nie istnieje dawka progowa, poniżej której to ryzyko by nie występowało. W ostatnich latach o ryzyku powikłań kardiologicznych u pacjentek napromienianych z powodu raka piersi dyskutowano wielokrotnie; zagadnienie to pojawia się zarówno w piśmiennictwie jak i jako stały element prezentacji konferencyjnych. Poniżej spleciono ze sobą krótki przegląd piśmiennictwa z omawianego zakresu wraz ze streszczeniem bardzo interesującej prezentacji dotyczącej stanu obecnej wiedzy na temat kardiotoksyczności radioterapii raka piersi pt. 'Cardiac Issues in Breast Irradiation', którą przedstawił dr David E. Wazer z Tufts University School of Medicine w Bostonie oraz Alpert Medical School of Brown University w Providence na 56. Dorocznym Spotkaniu Amerykańskiego Towarzystwa Radioterapii Onkologicznej (American Society for Radiation Oncology -ASTRO) w 2014r. w San Francisco. AbstractBreast cancer is diagnosed annually in over one million women worldwide. According to the current standard, many of them will receive a complex, multidisciplinary treatment, with radiotherapy remaining a necessary part of it. Ionizing radiation is a known cardiotoxic agent. It has been demonstrated that radiation-related heart disease (RRHD) may already occur at doses < 20Gy and reveal after a long period of latency, usually after more than a decade. The extent of RRHD risk remains largely unknown, but it seems that there is no threshold value below which the risk would not occur. In recent years, the risk of cardiac complications in patients irradiated for breast cancer has been extensively discussed; the issue appears both in literature and as a permanent part of conference presentations. Below is a brief literature review of the subject including a summary of a very interesting presentation concerning the current state of knowledge Adres do korespondencji lek. med.

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Detection of defects in myocardial perfusion imaging in patients with early breast cancer treated with radiotherapy

Cited by 121 publications

References 33 publications

Ionizing radiation and atherosclerosis: Current knowledge and future challenges

Ionizing radiation and atherosclerosis: Current knowledge and future challenges

Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer?

Problem kardiotoksyczności radioterapii raka piersi

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