We analysed the dynamics of the potentially toxic and harmful species of Prorocentrum Ehrenberg in Bizerte Lagoon (important aquaculture area, Northern Tunisia), substantiating the possible driving forces (temperature, salinity and nutrients), based on a two-year database. We revealed that Prorocentrum spp. blooms of high magnitude (10 4 -10 5 cells l -1 ) occurred mostly during the period of late winter to early spring. We found five species of Prorocentrum, two of which, namely P. lima and P. cordatum, the most common during the field, are confirmed agents of Diarrhetic Shellfish Poisoning in various regions of the world. Prorocentrum sp., P. micans and P. gracile were however present only sporadically but with high cell abundances, exemplifying bloom densities. Canonical correspondence analysis revealed that P. minimum and P. lima were much more abundant in eutrophic waters characterized by high Chl a biomass, while P. gracile species occurred principally in warm waters. Furthermore, Prorocentrum sp. and P. micans seemed more likely to proliferate in saline waters with high concentrations of inorganic nutrients (nitrate, ammonia and phosphate). Our study calls attention to a possible intensification of DSP events in Bizerte Lagoon, given the propensity of Prorocentrum spp. to proliferate in a eutrophic system.