Detection of dopamine receptors in the area postrema

Stafanini, E; Clement‐Cormier, Yvonne C.

doi:10.1016/0014-2999(81)90540-9

Cited by 93 publications

(28 citation statements)

References 6 publications

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“…However, this finding does not exclude the possibility of some contribution to the amphetamine CTA by the area postrema, and this idea is consistent with the demonstration of dopamine receptors in this structure (Stefanini and Clement-Cormier 1981).…”

Section: Discussionsupporting

confidence: 75%

Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study

1986

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Amphetamine has rewarding properties in some behavioral paradigms, such as self-administration and conditioned place preference (CPP), but an aversive component is also apparent when the drug is tested with the conditioned taste aversion (CTA) paradigm. The present study was an attempt to determine the neuroanatomical substrates of the drug's rewarding and aversive effects. Previous evidence suggested that amphetamine's stimulation of activity in dopaminergic synapses is critical for both effects. Amphetamine was therefore micro-injected bilaterally (10 micrograms/0.5 microliter per side) into six different dopaminergic sites, each in a different group of animals: the medial prefrontal cortex, nucleus accumbens, anteromedial caudate nucleus, lateroventral caudate nucleus, amygdala, and the region subjacent to the area postrema (AP region). The effects of these injections in both the taste and place conditioning paradigms were examined in separate experiments. Of the six sites, a significant CPP was observed only with accumbens injections and a significant CTA was observed only with AP region injections. It was concluded that the accumbens plays a primary role in mediating the rewarding effects of amphetamine and that the AP region plays a primary role in mediating the CTA. This constitutes an anatomical disassociation of amphetamine's rewarding and aversive effects. The differential associative bias of place-reward and taste-aversion learning apparent in the results is discussed.

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Section: Discussionsupporting

confidence: 75%

Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study

1986

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“…Serotonin receptors are found in high concentrations in the area postrema of the brain stem. [21][22][23] Unfortunately, the plasma half-life of serotonin is only a few minutes. As a result, the hypothesis proposed by Goll et al 4 that intestinal ischemia releases intravascular serotonin to induce PONV has never been investigated directly with plasma serotonin measurements.…”

Section: Discussionmentioning

confidence: 99%

Supplemental oxygen does not prevent postoperative nausea and vomiting after gynecological laparoscopy

McKeen

Arellano

O’Connell

2009

Can J Anesth/J Can Anesth

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Purpose Postoperative nausea and vomiting are among the most common and distressing side effects of general anesthesia. Supplemental intraoperative 80% oxygen reduces postoperative nausea and vomiting following open and laparoscopic abdominal surgery. However, this benefit has not been observed in other patient populations. We undertook this study to evaluate the effect of 80% supplemental intraoperative oxygen on the incidence of postoperative nausea and vomiting following ambulatory surgery for laparoscopic tubal ligation. Methods Following Research Ethics Board approval, 304 subjects were enrolled into one of two arms of a randomized prospective controlled study. The intervention group (n = 147) breathed 80% oxygen and the control group (n = 145) breathed routine 30% oxygen (balance medical air) while both groups were receiving a standardized general anesthetic. Nausea was assessed as: none, mild, moderate, or severe; vomiting was any emetic episode or retching. Any assessment either greater than none (nausea) or greater than zero (vomiting) was considered positive. Results The incidence of postoperative nausea and vomiting up to 24 hr following surgery was 69% in the 80% oxygen intervention group and 65% in the 30% oxygen control group (P = 0.62). There were no differences in nausea alone, vomiting, or antiemetic use in the postoperative anesthetic care unit or at any time (pre-or postdischarge) up to 24 hr after surgery. Conclusions This trial of 304 women did not demonstrate that administering intraoperative supplemental 80% oxygen during ambulatory surgery for laparoscopic tubal ligation prevented postoperative nausea or vomiting during the initial postoperative 24 hr compared with women who received routine 30% oxygen.

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“…The area postrema contains 5-HT 3 , opioid and dopamine D 2 receptors [10][11][12]. In the nucleus of the solitary tract are enkephalin, muscarine and histamine receptors [9,13,14].…”

Section: Mechanism For Nausea and Vomitingmentioning

confidence: 99%

Prevention and Treatment of Postoperative Nausea and Vomiting

Kovac¹

2003

Antiemetic Therapy

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Detection of dopamine receptors in the area postrema

Cited by 93 publications

References 6 publications

Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study

Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study

Supplemental oxygen does not prevent postoperative nausea and vomiting after gynecological laparoscopy

Prevention and Treatment of Postoperative Nausea and Vomiting

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