Detection of Dysplasia or Cancer in 3.5% of Patients With Inflammatory Bowel Disease and Colonic Strictures

Fuméry, Mathurin; Chambrun, Guillaume Pineton de; Stefănescu, Carmen; Buisson, Anthony; Bressenot, Aude; Beaugerie, Laurent; Amiot, Aurélien; Altwegg, Romain; Savoye, Guillaume; Abitbol, Véred; Bouguen, Guillaume; Simon, M.; Duffas, Jean-Pierre; Hébuterne, Xavier; Nancey, Stéphane; Roblin, Xavier; Leteurtre, Emmanuelle; Bommelaer, Gilles; Lefèvre, Jérémie H.; Brunetti, Francesco; Guillon, F.; Bouhnik, Yoram; Peyrin–Biroulet, Laurent

doi:10.1016/j.cgh.2015.04.185

Cited by 88 publications

(71 citation statements)

References 19 publications

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“…The increased risk of neoplasia in colonic strictures in IBD has been documented to be as high as 40% in one study [15]. However, a more recent population-based study in France found a lower risk with 3.5% of patients with IBD and colonic strictures having dysplasia [16], indicating that closer surveillance may be needed in this group.…”

Section: Discussionmentioning

confidence: 99%

Nearly a Third of High-Grade Dysplasia and Colorectal Cancer Is Undetected in Patients with Inflammatory Bowel Disease

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Nearly a Third of High-Grade Dysplasia and Colorectal Cancer Is Undetected in Patients with Inflammatory Bowel Disease

et al. 2017

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“…The incidence of malignancy in patients with CD and colitis is comparable to that of patients with UC 154, 155 . Among patients with a colonic stricture and endoscopic biopsies and brush findings negative for dysplasia or cancer, 3.5% of those who underwent surgical resection were found to have dysplasia or malignancy in a histopathologic evaluation 156 . If a patient with CD has a colonic stricture at diagnosis or during follow up, the risks for colorectal cancer at 5 and 10 years are 3.6% and 4.9%, respectively 157 .…”

Section: Management Of Fibrostenosing Ibdmentioning

confidence: 99%

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

2017

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In the last 10 years, we have learned much about the pathogenesis, diagnosis, and management of intestinal fibrosis in patients with inflammatory bowel diseases (IBD). Just a decade ago, intestinal strictures were considered to be an inevitable consequence of long-term inflammation in patients who did not respond to anti-inflammatory therapies. IBD-associated fibrosis was seen as an irreversible process that frequently led to intestinal obstructions requiring surgical intervention. This paradigm has changed rapidly, due to the anti-fibrotic approaches that may become available. We review the mechanisms and diagnosis of this serious complication of IBD, as well as factors that predict its progression and management strategies.

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“…tub1 = Well-differentiated tubular adenocarcinoma; muc = mucinous adenocarcinoma; scc = squamous cell carcinoma. Japan, anorectal cancer is common; therefore, in addition to the colonoscopy, the biopsy of the perianal region is necessary for adequate surveillance [26][27][28][29][30] . We performed surveillance in patients with complicated perianal lesions that had persisted for at least 7 years.…”

Section: Discussionmentioning

confidence: 99%

Detection of Anorectal Cancer among Patients with Crohn's Disease Undergoing Surveillance with Various Biopsy Methods

et al. 2016

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Background/Aims: Crohn's disease (CD) is an inflammatory bowel disease. The risk of colorectal cancer (CRC) is increased in patients with CD. In Japan, anorectal cancer accounted for >60% of CRCs associated with CD. These anorectal cancers are typically diagnosed in advanced stages, because a surveillance protocol remains to be established. This study aimed to assess various biopsy methods for detecting CRC. Methods: This study included 72 patients (113 examinations) with CD who underwent cancer surveillance between August 2008 and October 2015. Surveillances were performed with a core needle biopsy in perianal regions (54 cases), endoscopic biopsy (90 cases), and excisional biopsy (34 cases). When it was difficult to perform colonoscopy in an outpatient setting, due to perianal pain or stricture, we employed examinations under anesthesia for surveillance. Results: The total CRC detection rate was 6.19% (7 examinations). CRC detection rates were 1.85% (1 case) with core needle biopsy, 5.56% (5 cases) with endoscopic biopsy, and 5.88% (2 cases) with excisional biopsy. Conclusions: We showed that it was important to employ various biopsy methods in cancer surveillance to detect CRC among patients with CD.

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Detection of Dysplasia or Cancer in 3.5% of Patients With Inflammatory Bowel Disease and Colonic Strictures

Abstract: In a retrospective study of patients with IBD undergoing surgery for colonic strictures, 3.5% were found to have dysplasia or cancer. These findings can be used to guide management of patients with IBD and colonic strictures.

Cited by 88 publications

References 19 publications

Nearly a Third of High-Grade Dysplasia and Colorectal Cancer Is Undetected in Patients with Inflammatory Bowel Disease

Nearly a Third of High-Grade Dysplasia and Colorectal Cancer Is Undetected in Patients with Inflammatory Bowel Disease

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

Detection of Anorectal Cancer among Patients with Crohn's Disease Undergoing Surveillance with Various Biopsy Methods

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