Detection of Entamoeba histolytica, Giardia lamblia and Cryptospodium sp. Infection among diarrheal patients

Khanum, Hamida; Kadir, Rukhshana; Arju, Tuhinur; Ahmed, Tahmina; Karim, Mt Tahmina; Sultana, Asma; Huque, Rashidul

doi:10.3329/bjz.v43i1.26132

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Ketaren and Prasetyo (2000) stated that nutrient needs for 1-16 weeks aged of layer ducks has lower growth phase at 85-100% of the nutrition table for local layer ducks including Alabio layer ducks from South Kalimantan (Setioko and Rohaeni, 2001). This variation shows the importance of local layer ducks nutrition research (Khanum et al, 2005;Wang et al, 2010).…”

Section: Introductionmentioning

confidence: 81%

Production increase of alabio duck by predicting real nutrients needs on crude proteins and metabolizable energy in feed

2014

Int. J. Biosci.

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The purpose of this study was to determine the real of nutrients needs, especially crude protein and metabolizable energy in production phase of Alabio duck, to achieve optimal production. Experimental method was performed through observation and measurement of the parameters on the basic needs of life (basal metabolism and activity), body weight growth and egg production. The study conducted for 4 weeks using 50 Alabio ducks on age of 7 months in the production phase. Protein estimation measured by Sibbald (1989) method, while metabolic energy requirements used Amrullah ( 2004) method. The results showed that the measurement of the real needs of the protein is 19%, while the metabolic energy requirement is 2650 kcal.kg -1 .The results of this study were expected to optimize the nutrient production levels due to the production demand of Alabio duck.

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Section: Introductionmentioning

confidence: 81%

Production increase of alabio duck by predicting real nutrients needs on crude proteins and metabolizable energy in feed

2014

Int. J. Biosci.

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“…Of these, parasitic protozoa form a major group, with the apicomplexans and kinetoplastid parasites represented by important members, which cause diseases such as malaria, cryptosporidiosis, toxoplasmosis, babesiosis, leishmaniasis, Human African trypanosomiasis and south American trypanosomiasis or Chagas' disease causing most of the morbidity and mortality 4,5 . Other important diseases caused by protozoans include giardiasis, amoebic dysentery 6,7 and trichomoniasis 8 . A vicious cycle of poverty and disease exists for most of these parasites with a high infection and death rate in affected populations [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens

Falade

Otarigho

2017

F1000Res

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Background: Medically important pathogens are responsible for the death of millions every year. For many of these pathogens, there are limited options for therapy and resistance to commonly used drugs is fast emerging. The availability of genome sequences of many eukaryotic microbes is providing critical biological information for understanding parasite biology and identifying new drug and vaccine targets. Methods: We developed automated search strategies in the Eukaryotic Pathogen Database Resources (EuPathDB) to construct a protein list and retrieve protein sequences of folate transporters encoded in the genomes of 200 eukaryotic microbes. The folate transporters were categorized according to features including mitochondrial localization, number of transmembrane helix, and protein sequence relatedness. Results: We identified 234 folate transporter proteins associated with 63 eukaryotic microbes including 48 protozoa, 13 fungi the others being algae and bacteria. Phylogenetic analysis placed 219 proteins into a major clade and 15 proteins into a minor clade. All the folate transporter sequences from the malaria parasite, Plasmodium, belonged to the major clade. The identified folate transporters include folate-binding protein YgfZ, folate/pteridine transporter, folate/biopterin transporter, reduced folate carrier family protein and folate/methotrexate transporter FT1. About 60% of the identified proteins are reported for the first time. Phylogeny computation shows the similarity of the proteins identified. Conclusion: These findings offer new possibilities for potential drug development targeting folate-salvage proteins in eukaryotic pathogens.

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Genome-wide characterization of folate transporter proteins of eukaryotic pathogens

Falade

Otarigho

2017

F1000Res

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Background:Medically important pathogens are responsible for the death of millions every year. For many of these pathogens, there are limited options for therapy and resistance to commonly used drugs is fast emerging. The availability of genome sequences of many eukaryotic protozoa is providing important data for understanding parasite biology and identifying new drug and vaccine targets. The folate synthesis and salvage pathway are important for eukaryote pathogen survival and organismal biology and may present new targets for drug discovery.Methods:We applied a combination of bioinformatics methods to examine the genomes of pathogens in the EupathDB for genes encoding homologues of proteins that mediate folate salvage in a bid to identify and assign putative functions. We also performed phylogenetic comparisons of identified proteins. .Results:We identified 234 proteins to be involve in folate transport in 63 strains, 28 pathogen species and 12 phyla, 60% of which were identified for the first time. Many of the genomes examined contained genes encoding transporters such as folate-binding protein YgfZ, folate/pteridine transporter, folate/biopterin transporter, reduced folate carrier family protein, folate/methotrexate transporter FT1. The mitochondrion is the predicted location of the majority of the proteins, with 15% possessing signal peptides. Phylogeny computation shows the similarity of the proteins identified.Conclusion:These findings offer new possibilities for potential drug development targeting folate-salvage proteins in eukaryotic pathogens.

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Detection of Entamoeba histolytica, Giardia lamblia and Cryptospodium sp. Infection among diarrheal patients

Cited by 3 publications

References 19 publications

Production increase of alabio duck by predicting real nutrients needs on crude proteins and metabolizable energy in feed

Production increase of alabio duck by predicting real nutrients needs on crude proteins and metabolizable energy in feed

Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens

Genome-wide characterization of folate transporter proteins of eukaryotic pathogens

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