Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas

Nagore, Eduardo; Ledesma, Eduardo; Collado, C.; Oliver, Verity F.; Pérez‐Pérez, Alejandro; Aliaga, Adolfo

doi:10.1046/j.1365-2133.2000.03657.x

Cited by 60 publications

(52 citation statements)

References 15 publications

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“…Although viruses are known to provide chronic immune stimulation, the findings of their association with MF are controversial (Pancake et al, 1995;Boni et al, 1996;Nagore et al, 2000;Herne et al, 2003). HTLV-1 is found in adult T-cell lymphoma and leukemia, and it has been implicated by several studies in CTCL (Zucker-Franklin and Pancake, 1994;Pancake et al, 1995;Khan et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?

et al. 2006

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Mycosis fungoides (MF) is the most frequently found cutaneous T-cell lymphoma with an unknown aetiology. Several aetiopathogenetic mechanisms have been postulated, including persistent viral or bacterial infections. We looked for evidence of Borrelia burgdorferi (Bb), the aetiologic agent of Lyme disease (LD), in a case study of MF patients from Northeastern Italy, an area with endemic LD. Polymerase chain reaction for the flagellin gene of Bb was used to study formalin-fixed paraffin-embedded lesional skin biopsies from 83 patients with MF and 83 sex-and age-matched healthy controls with homolocalised cutaneous nevi. Borrelia burgdorferi-specific sequence was detected in 15 out of 83 skin samples of patients with MF (18.1%), but in none out of 83 matched healthy controls (Po0.0001). The Bb positivity rates detected in this study support a possible role for Bb in the aetiopathogenesis of MF in a population endemic for LD.

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Section: Discussionmentioning

confidence: 99%

Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?

et al. 2006

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“…2,3 The factors that drive a T-cell clone to proliferate and to escape from the immune control are not clearly understood. The pathogenic role of viruses [4][5][6] ; other epidermal cells, such as keratinocytes and dendritic cells 7,8 ; or aberrant secretion or response to certain cytokines, such as transforming growth factor ␤ (TGF␤), interferon ␥ (IFN␥), and interleukin 10 (IL-10), [9][10][11] have been evoked. CTCL may also be considered a result of defective negative regulation of cell growth, survival, or both.…”

Section: Introductionmentioning

confidence: 99%

Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling

Nikolova

Musette

Bagot

et al. 2002

Blood

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Extensive phenotype analysis of cutaneous T-cell lymphoma (CTCL) malignant cell lines revealed surface expression of receptors usually not detected on normal circulating CD4 ؉ CD45RO ؉ lymphocytes. We previously found that CTCL malignant cells express the killer cell immunoglobulinlike receptor (KIR) KIR3DL2/CD158k, whereas they fail to express the other KIRs. In the present study, we report for the first time that the CD85j/immunoglobulin (Ig)-like transcript 2 (ILT2) receptor is found on Sé zary cell lines and on circulating Sé zary malignant CD4 ؉ cells, while it is hardly detectable on circulating CD4 ؉ lymphocytes from healthy individuals. We demonstrate that ILT2 is functional on CTCL cells, as its triggering leads to the recruitment of Src homology 2 domaincontaining tyrosine phosphatase (SHP-1) and to the specific inhibition of CTCL malignant cell proliferation induced by CD3/T-cell receptor (TCR) stimulation. Interestingly, we found that separated CD4 ؉ ILT2 ؉ circulating malignant Sé zary cells are less susceptible to anti-CD3 monoclonal antibody (mAb)-induced cell death than autologous CD4 ؉ ILT2 ؊ lymphocytes. Therefore, the resistance to apoptosis of Sé zary cells may result from distinct mechanisms including cytokineinduced high levels of bcl-2 and specific expression of inhibitory receptors involved in lymphocyte survival. (Blood.

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“…The role of HHV-8 in the pathogenesis of other tumors remains controversial. 17,18 There have been occasional reports of the association of HHV-8 with cutaneous T-cell lymphomas and nonneoplastic lymphoproliferative cutaneous conditions such as large-plaque parapsoriasis (LPP), based on molecular analysis, 19,20 although serologic assays have not been performed in the same patients. Serologic analysis in patients with various malignancies, hematologic or neurologic diseases, and autoimmune conditions have not shown significant association with HHV-8 infection.…”

mentioning

confidence: 99%

Human Herpesvirus 8 Infection in Patients With Cutaneous Lymphoproliferative Diseases

Trento

Castilletti

Ferraro³

et al. 2005

Arch Dermatol

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Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas

Abstract: The findings indicate that EBV, HHV-7 and HHV-8 seem not to be involved in the pathogenesis of PCL.

Cited by 60 publications

References 15 publications

Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?

Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?

Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling

Human Herpesvirus 8 Infection in Patients With Cutaneous Lymphoproliferative Diseases

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