Detection of Epstein-Barr virus in synovial fluid of rheumatoid arthritis patients

Mahabadi, Mostafa; Faghihiloo, Ebrahim; Alishiri, Gholam Hossein; Ataee, Mohamad Hossein; Ataee, Ramezan Ali

doi:10.19082/2181

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…EBV is a DNA virus from the Herpesviridae family, involved in Hodgkin's lymphoma, Burkitt's lymphoma (as B‐cell cancres), nasopharyngeal carcinoma, gastric cancer (as epithelial malignancies), and autoimmune diseases . In these tumors, EBV establishes latent infections, expressing only a subset of viral genes, allowing the virus to affect cellular signaling contributing to oncogenesis .…”

Section: Tumor‐caused Viruses and Tgf‐β Signalingmentioning

confidence: 99%

Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer

Mirzaei

Faghihloo

2018

Reviews in Medical Virology

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Transforming growth factor-β (TGF-β) signaling pathway is a key network in cell signaling that controls vital processes such as proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and migration, thus acting as a double-edged sword in normal development and diseases, in particular organ fibrosis, vascular disorders, and cancer. Early in tumorigenesis, the pathway exerts anti-tumor effects through suppressing cell cycle and inducing apoptosis, while during late stages, it functions as a tumor promoter by enhancing tumor invasiveness and metastasis. This signaling pathway can be perturbed by environmental and genetic factors such as microbial interference and mutation, respectively. In this way, the present review describes the modulation of the TGF-β pathway by oncogenic human viral pathogens and other viruses. The main mechanisms by which viruses interferes with TGF-β signaling seems to be through (1) the alteration of either TGF-β protein expression or activation, (2) the modulation of the TGF-β receptors or SMADs factors (by interfering with their levels and functions), (3) the alteration of none-SMAD pathways, and (4) indirect interaction with the pathway by the modulation of transcriptional co-activator/repressor and regulators of the pathway. Given the axial role of this pathway in tumorigenesis, it can be regarded as an attractive target for cancer therapy. Hence, further investigations on this subject may represent molecular targets among either TGF-β signaling molecules or viral factors for the treatment and management of viral infection consequences such as cancer.

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Section: Tumor‐caused Viruses and Tgf‐β Signalingmentioning

confidence: 99%

Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer

Mirzaei

Faghihloo

2018

Reviews in Medical Virology

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“…[ 35 ] Moreover, virus such as rubella virus and Epstein–Barr virus (EBV) is the initiator of RA. [ 36 ] Furthermore, the alteration in the composition and function of intestinal microbiome has been associated with rheumatoid arthritis, that is patients having decreased gut microbiome diversity as compared to the healthy individuals. [ 37 ] Smoking is also one of the causative factors of rheumatoid arthritis as it contributes to the development of RF factor which is up to three times more common in smokers than non‐smokers.…”

Section: Aetiological Factors Of Rheumatoid Arthritismentioning

confidence: 99%

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Singh

Mahajan

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self‐neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self‐epitopes as biomarkers in RA provides a better understanding of pathogenesis of disease and has led to the development of novel therapeutic approaches acting as potent inhibitors of these cells. Key findings The current review retrieved the various medicinal plants possessing an active phytoconstituents with anti‐inflammatory and antioxidant properties, which tends to be effective alternative approach over the synthetic drugs concerned with high toxic effects. The current available literature provided an evident data concluding that the active constituents like fatty acids, flavonoids, terpenes and sesquiterpene lactones attenuate the RA symptoms by targeting the inflammatory biomarkers involved in the pathogenesis of RA. Summary Despite the various synthetic treatment approaches targeting immune cells, cytokines improved the quality of life but still the drug management is challenging due to toxic and chronic teratogenic effects with anti‐arthritic drugs. The current review has elaborated the selected traditionally used herbal medicinal plants with phytoconstituents possessing anti‐inflammatory activity by suppressing the inflammatory biomarkers with lesser side effects and providing the future exploration of natural drug therapy for rheumatoid arthritis.

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“…EBV has been implicated in the pathogenic manifestation of RA. Patients with this disorder demonstrate elevated EBV reactive antibody titers and impaired lymphocyte responses to EBV, and EBV has been identified in the synovial fluid of patients with RA, indirectly implicating EBV in RA pathogenesis 63– 65 . Modeling this pathological phenotype, humanized NOG mice infected with EBV develop an erosive arthritis.…”

Section: Humanized Mouse Models Of Epstein-barr Virus Infectionmentioning

confidence: 99%

Recent advances in understanding Epstein-Barr virus

Stanfield

Luftig

2017

F1000Res

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Epstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population. Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has been linked to nearly 10% of all gastric cancers. Furthermore, recent advances in high-throughput next-generation sequencing and the development of humanized mice, which effectively model EBV pathogenesis, have led to a wealth of knowledge pertaining to strain variation and host-pathogen interaction. This review highlights some recent advances in our understanding of EBV biology, focusing on new findings on the early events of infection, the role EBV plays in gastric cancer, new strain variation, and humanized mouse models of EBV infection.

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Detection of Epstein-Barr virus in synovial fluid of rheumatoid arthritis patients

Cited by 13 publications

References 28 publications

Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer

Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Recent advances in understanding Epstein-Barr virus

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