Detection of Explosives Using Field‐Effect Transistors

Sharon, Etery; Freeman, Ronit; Willner, Itamar

doi:10.1002/elan.200900271

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…E. Sharon et al achieved 10 -7 M TNT detection limit using ISFET functionalized with the π-donor units like 6-hydroxydopamine or 4-aminothiophenol [3]. Another type of FETs, carbon nanotubes, CNT-FETs, and single-wall nanotubes, CNWT-FETs, were also previously used for development of devices for explosives detection.…”

Section: Page 13 Of 40mentioning

confidence: 97%

“…M a n u s c r i p t 3 A fully depleted silicon-on-insulator-based ISFET was used as the electronic signal transducer, because it is highly sensitive to changes in the gate solution [12]. Escherichia coli nitroreductase (NTR, EC 1.5.1.34) was used as the receptor layer of the sensor device.…”

Section: Fugurementioning

confidence: 99%

“…Earlier various types of field-effect transistors (FET) were shown to be efficient for detection of trinitrotoluene [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Development of a novel enzymatic biosensor based on an ion-selective field effect transistor for the detection of explosives

Комарова

Andrianova

Gubanova

et al. 2015

Sensors and Actuators B: Chemical

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Section: Page 13 Of 40mentioning

confidence: 97%

Section: Fugurementioning

confidence: 99%

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Development of a novel enzymatic biosensor based on an ion-selective field effect transistor for the detection of explosives

Комарова

Andrianova

Gubanova

et al. 2015

Sensors and Actuators B: Chemical

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“…thrombin 22–24 or lysozyme 25, of adenosine triphosphate (ATP) 26 as well as organic compounds such as e.g. cocaine 27. The changes of the structural integrity of aptamers upon binding of their substrate play a crucial role in the overall recognition process.…”

Section: Introductionmentioning

confidence: 99%

Impedimetric Detection of Hairpin Ribozyme Activity

et al. 2010

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Electrochemical impedance spectroscopy is successfully utilized for label-free monitoring of the cleavage reaction of a RNA substrate by a complementary hairpin ribozyme. The formation of the RNA substrate/ribozyme complex is increasing the negative charge at the interface and is modulating the kinetic of the redox conversion of a negatively charged redox mediator (e.g. [Fe(CN) 6 ] 3À/4À ) hence leading to an increase in the charge transfer resistance. Upon addition of bivalent cations such as Mg 2 + ions the conformation of the ribozyme is changed and the catalytic cleavage of the RNA is monitored by a decrease of the charge transfer resistance.

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“…We, then, implemented the (4)-and (6)-modified sensing modules for the analysis of TNT, (8), and of RDX, (9). The luminescence spectra of the (4)-and (6)-modified sensing modules, in the presence of variable concentrations of TNT (8), are depicted in Figures S2 and S3, Supporting Information.…”

mentioning

confidence: 99%

Ag Nanocluster/DNA Hybrids: Functional Modules for the Detection of Nitroaromatic and RDX Explosives

et al. 2014

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Luminescent Ag nanoclusters (NCs) stabilized by nucleic acids are implemented as optical labels for the detection of the explosives picric acid, trinitrotoluene (TNT), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). The sensing modules consist of two parts, a nucleic acid with the nucleic acid-stabilized Ag NCs and a nucleic acid functionalized with electron-donating units, including L-DOPA, L-tyrosine and 6-hydroxy-L-DOPA, self-assembled on a nucleic acid scaffold. The formation of donor-acceptor complexes between the nitro-substituted explosives, exhibiting electron-acceptor properties, and the electron-donating sites, associated with the sensing modules, concentrates the explosives in close proximity to the Ag NCs. This leads to the electron-transfer quenching of the luminescence of the Ag NCs by the explosive molecule. The quenching of the luminescence of the Ag NCs provides a readout signal for the sensing process. The sensitivities of the analytical platforms are controlled by the electron-donating properties of the donor substituents, and 6-hydroxy-L-DOPA was found to be the most sensitive donor. Picric acid, TNT, and RDX are analyzed with detection limits corresponding to 5.2 × 10(-12) M, 1.0 × 10(-12) M, and 3.0 × 10(-12) M, respectively, using the 6-hydroxy-L-DOPA-modified Ag NCs sensing module.

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Detection of Explosives Using Field‐Effect Transistors

Cited by 15 publications

References 34 publications

Development of a novel enzymatic biosensor based on an ion-selective field effect transistor for the detection of explosives

Development of a novel enzymatic biosensor based on an ion-selective field effect transistor for the detection of explosives

Impedimetric Detection of Hairpin Ribozyme Activity

Ag Nanocluster/DNA Hybrids: Functional Modules for the Detection of Nitroaromatic and RDX Explosives

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