Detection of extrathoracic metastases by positron emission tomography in lung cancer

Weder, Walter; Schmid, Ralph A.; H, Bruchhaus; Hillinger, Sven; Schulthess, Gustav K. von; Steinert, H.

doi:10.1016/s0003-4975(98)00675-4

Cited by 206 publications

(84 citation statements)

References 11 publications

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“…However, the negative predicative value of PET for N3 disease was identical to that of mediastinoscopy (96%) prompting the statement that patients with negative mediastinal PET findings could go directly to surgical resection of the primary lesion [69]. This approach has been supported by other authors [59,68]. Positive PET findings however warrant nodal biopsy, as guided by the areas of increased FDG uptake, in order to exclude false positives.…”

Section: Positron Emission Tomographymentioning

confidence: 86%

“…In a study of 50 patients where PET and CT findings were reported jointly, the sensitivity rose to 93%, specificity 97% and accuracy 96% in the detection of mediastinal nodal disease [63]. PET has been shown to detect occult extrathoracic metastases in 11-14% of patients selected for curative resection and alter management in up to 40% of cases [66][67][68].…”

Section: Positron Emission Tomographymentioning

confidence: 99%

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Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

124

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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Section: Positron Emission Tomographymentioning

confidence: 86%

Section: Positron Emission Tomographymentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

124

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“…If 18 F-FDG PET/CT is positive, then mediastinoscopy is necessary to exclude a false-positive result 59 . 18 F-FDG PET/CT detects unexpected extrathoracic metastases ( Figure 5 ) in 11% to 15% of asymptomatic patients, avoiding futile surgical intervention 707576…”

Section: Methodsmentioning

confidence: 99%

¹⁸F-FDG PET/CT Imaging In Oncology

Almuhaideb

Παπαθανασίου

Bomanji

2011

Annals of Saudi Medicine

286

123

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Accurate diagnosis and staging are essential for the optimal management of cancer patients. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) has emerged as a powerful imaging tool for the detection of various cancers. The combined acquisition of PET and CT has synergistic advantages over PET or CT alone and minimizes their individual limitations. It is a valuable tool for staging and restaging of some tumors and has an important role in the detection of recurrence in asymptomatic patients with rising tumor marker levels and patients with negative or equivocal findings on conventional imaging techniques. It also allows for monitoring response to therapy and permitting timely modification of therapeutic regimens. In about 27% of the patients, the course of managment is changed. This review provides guidance for oncologists/ radiotherapists and clinical and surgical specialists on the use of 18F-FDG PET/CT in oncology.

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“…False positive PET scans can be seen in patients with inflammatory conditions (sarcoidosis or rheumatoid nodules) or infectious processes (endemic mycosis or mycobacterial infection). However, occasionally PET demonstrates evidence of lymph node involvement or extrapulmonary disease that might not otherwise have been detected [38] [39].…”

Section: ) Careful Observationmentioning

confidence: 99%

Differentiation of Benign and Malignant Solitary Pulmonary Nodule: Literature Review

Tripathi¹,

Zhen²

2015

ALC

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The solitary pulmonary nodule (SPN) is frequently seen on chest radiographs and computed tomography (CT), usually the identification is accidental. The overall prevalence of malignancy is relatively low but identification of malignancy of nodule is of prime importance. There are different characters of nodules indicating malignancy, and also the exposure of person to risk factors increases the chances of malignancy of nodule. Chances of malignancy rise with increasing size, the irregular, lobulated border of the nodules is highly associated with higher probability of malignancy and nodules with pure ground grass appearance have higher probability of malignancy, irregularly marginated nodule displaying a corona radiata sign indicating neoplastic infiltration with distortion of neighbouring tissue is almost certainly a malignant nodule. Stippled, punctuate, and eccentric calcifications are suggestive of malignancy. There are 20% -75% of chances of malignancy if nodule is appeared with ground-glass opacity. Malignant nodules have higher growth rate as compared with benign nodules, malignant nodules usually have doubling time (DT) of 30 -400 days while DT of more than 450 days is sign of benignity whereas doubling time less than 30 days is usually acute infectious process. The presence of fat within nodule is sign of benignity. Increasing density of the nodule is suggestive of malignancy and requires shorter follow up. Besides the nodule evaluation the chances of malignancy can also be evaluated through the exposure of patient to risk factors like age, current and past smoking status and history of extra thoracic malignancy. The management depends upon various factors mainly three strategies are applied for management including careful observation of nodule, use of diagnostic techniques like CT FNA, PET, and broncoscopy and surgery.

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Detection of extrathoracic metastases by positron emission tomography in lung cancer

Cited by 206 publications

References 11 publications

Diagnostic imaging of lung cancer

Diagnostic imaging of lung cancer

¹⁸F-FDG PET/CT Imaging In Oncology

Differentiation of Benign and Malignant Solitary Pulmonary Nodule: Literature Review

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Detection of extrathoracic metastases by positron emission tomography in lung cancer

Cited by 206 publications

References 11 publications

Diagnostic imaging of lung cancer

Diagnostic imaging of lung cancer

18F-FDG PET/CT Imaging In Oncology

Differentiation of Benign and Malignant Solitary Pulmonary Nodule: Literature Review

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¹⁸F-FDG PET/CT Imaging In Oncology