Detection of fatty acid composition of trabecular bone marrow by localized iDQC MRS at 3 T: A pilot study in healthy volunteers

Bao, Jianfeng; Zhuang, Yuchuan; Chen, Zhong; Cheng, Jingliang; Zhong, Jianhui

doi:10.1016/j.mri.2020.09.007

Cited by 4 publications

(8 citation statements)

References 48 publications

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“…We showed that BMAT unsaturation was higher within the femur compared to the tibia and that BMAT unsaturation was higher within the diaphysis of the tibia and femur compared to the proximal or distal metaphysis, but we found no gender- or age-associated differences in BMAT unsaturation. Our results are comparable to a study by Bao who reported higher BMAT unsaturation within the distal femur compared to the proximal tibia, and no differences in BMAT unsaturation between young male and female subjects ( 38 ). Our results partially differ from the study by Scheller and coworkers in 5 young female subjects, as they report higher BMAT unsaturation, measured using 1 H-MRS, within the tibia compared to the femur.…”

Section: Discussionsupporting

confidence: 86%

Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water–Fat MRI

et al. 2022

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Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. The aim of this study is to determine region-specific variations and age- and gender-specific differences in BMAT and BMAT composition in healthy subjects. In this cross-sectional study, we included 40 healthy subjects (26 male: mean age 49 years, range 22–75 years; 14 female: mean age 50 years, range 29–71) and determined the bone marrow signal fat fraction and bone marrow unsaturation in the spine (C3-L5), pelvis, femora, and tibiae using chemical shift encoding-based water–fat imaging (WFI) with multiple gradient echoes (mGRE). Regions of interest covered the individual vertebral bodies, pelvis and proximal epimetaphysis, diaphysis, and distal epimetaphysis of the femur and tibia. The spinal fat fraction increased from cervical to lumbar vertebral bodies (mean fat fraction ( ± SD or (IQR): cervical spine 0.37 ± 0.1; thoracic spine 0.41 ± 0.08. lumbar spine 0.46 ± 0.01; p < 0.001). The femoral fat fraction increased from proximal to distal (proximal 0.78 ± 0.09; diaphysis 0.86 (0.15); distal 0.93 ± 0.02; p < 0.001), while within the tibia the fat fraction decreased from proximal to distal (proximal 0.92 ± 0.01; diaphysis 0.91 (0.02); distal 0.90 ± 0.01; p < 0.001). In female subjects, age was associated with fat fraction in the spine, pelvis, and proximal femur (ρ = 0.88 p < 0.001; ρ = 0.87 p < 0.001; ρ = 0.63 p = 0.02; ρ = 0.74 p = 0.002, respectively), while in male subjects age was only associated with spinal fat fraction (ρ = 0.40 p = 0.04). Fat fraction and unsaturation were negatively associated within the spine (r = -0.40 p = 0.01), while in the extremities fat fraction and unsaturation were positively associated (distal femur: r = 0.42 p = 0.01; proximal tibia: r = 0.47, p = 0.002; distal tibia: r = 0.35 p = 0.03), both independent of age and gender. In conclusion, we confirm the distinct, age- and gender-dependent, distribution of BMAT throughout the human skeleton and we show that, contradicting previous animal studies, bone marrow unsaturation in human subjects is highest within the axial skeleton compared to the appendicular skeleton. Furthermore, we show that BMAT unsaturation was negatively correlated with BMAT within the spine, while in the appendicular skeleton, BMAT and BMAT unsaturation were positively associated.

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Section: Discussionsupporting

confidence: 86%

Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water–Fat MRI

et al. 2022

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“…This is because the peak at 0.9 ppm is very close to the peak at 1.3 ppm, which was used to generate the DDF here, and maybe partially excited by a selective pulse. This can be attributed to the unrevealed FAs peak at 4.3 ppm to the low signal-to-noise ratio of the iDQC-MRS, which is only about 10% of that of conventional MRS. 24,25 Long TE MRS and diffusion-weighted MRS techniques have been proposed to study the bone marrow FAs composition due to the transverse relaxation time of the unsaturated fatty being longer than that of the saturated components. 16 However, both methods have been applied to explore the yellow bone marrow FAs in the absence of honeycombed trabecular bone.…”

Section: Discussionmentioning

confidence: 99%

“…Then, automatic integration was performed to obtain the quantitative information of all the five crossing peaks. The composition levels of saturated and UFAs were calculated according to previous studies 23,24 using the following equations:…”

Section: Data Acquisition and Fas Composition Quantificationmentioning

confidence: 99%

“…23 More recently, the feasibility and effectiveness of intermolecular double-quantum coherence-based magnetic resonance spectroscopy (iDQC-MRS) have been demonstrated, which is one of the iMQC techniques, in improving the spectra resolution of bone marrow fat in the presence of trabecular bone on a clinical 3.0 T scanner. 24 This study aimed to use the resolution-enhanced iDQC-MRS technique to explore the FAs composition of the vertebral bone in the presence of trabecular bone in PMOP and age-matched healthy controls (HC).…”

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confidence: 99%

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Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC‐MRS on 3.0 T Study

Bao

Zhang

et al. 2022

Magnetic Resonance Imaging

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Background: Unsaturated fatty acids (UFAs) of bone marrow play a critical role in osteoporosis. However, it is difficult to resolve the UFA, especially in the presence of trabecular bone, using conventional magnetic resonance spectroscopy (MRS) methods. Purpose: To preliminarily compare the bone marrow fatty acids (FAs) composition in the presence of trabecular bone of postmenopausal osteoporosis (PMOP) and healthy controls (HC). Study Type: Prospective. Subjects: Total thirty-six postmenopausal women were recruited with CT-confirmed PMOP (n = 19) and HC (n = 17). Field Strength/Sequences: A 3 T scanner. Localized 2D intermolecular double-quantum coherence-based MRS (iDQC-MRS). Assessment: In addition to the conventional water and fat peaks, another four crossing peaks of the FAs were well resolved from the L4 vertebral bone marrow using iDQC-MRS technique: allylic methylene (2.0 ppm), terminal methylene (2.2 ppm), diallylic methylene (2.7 ppm), and olefinic (5.3 ppm). The monounsaturated fatty acids (MOFA) and polyunsaturated fatty acids (PUFAs) were then calculated. Statistical Tests: Differences between PMOP and HC were investigated using the analysis of a t-test, and the relationships were investigated using regression analysis. Results: MOFAs and PUFAs fractions were significantly lower in the PMOP group compared to the HC group. In contrast, the saturated FAs fraction is significantly higher in the PMOP group. Additionally, decreased PUFAs, MOFAs were moderately negatively correlated with the volumetric bone mineral density (vBMD) in the PMOP group. Furthermore, increased SFAs in PMOP were strongly associated with vBMD. Data Conclusion: Using spectra resolution enhanced 2D iDQC-MRS technique, we observed low unsaturated FAs levels in the vertebral bone marrow of the PMOP patients. The reduced unsaturated FAs levels in PMOP may be associated with dysfunction of the balance between osteoblastogenesis and osteoclastogenesis. Level of Evidence: 2. Technical Efficacy Stage: 1.

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“…9 iDQC-MRS has been previously employed to improve the resolution of in vivo bone marrow spectra in the distal tibia. 10 The authors use the same methodology now in the spine to compare bone marrow fatty acid composition between postmenopausal osteoporosis (PMOP) subjects and healthy controls (HC). The acquired 2D spectra show a good ability to spectrally resolve the most important fat peaks in both POMP subjects and HC.…”

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confidence: 99%

Editorial for “Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC‐MRS on 3.0 T Study”

Ruschke

Karampinos

2022

Magnetic Resonance Imaging

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Detection of fatty acid composition of trabecular bone marrow by localized iDQC MRS at 3 T: A pilot study in healthy volunteers

Cited by 4 publications

References 48 publications

Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water–Fat MRI

Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water–Fat MRI

Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC‐MRS on 3.0 T Study

Editorial for “Low Unsaturated Fatty Acids Level in the Vertebral Bone Marrow of Postmenopausal Osteoporosis: A Pilot 2D iDQC‐MRS on 3.0 T Study”

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