Detection of focal renal perfusion defects in rabbits after sulphur hexafluoride-filled microbubble injection at low transmission power ultrasound insonation

Quaia, Emilio; Siracusano, Salvatore; Palumbo, Alessandro; Ciciliato, Stefano; Rossi, Stefania; Bruni, Stefano; Bussani, Rossana; Cova, Maria Assunta

doi:10.1007/s00330-005-2866-y

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Several studies have shown the potential of CEUS for improving the depiction of intrarenal blood flow, both in normal and pathological conditions. This technique has been found to be an effective way of depicting focal renal perfusion defects in pig and rabbit [7,[16][17][18], and preliminary investigation in man confirm these results [8,19,20]. To the best of our knowledge, however, no systematic investigation has been performed in man to test the accuracy of CEUS in comparison with established imaging techniques.…”

Section: Introductionsupporting

confidence: 58%

“…Grey-scale ultrasonography (US) is highly insensitive for detecting acute renal infarction [7], and evaluation of renal perfusion with Doppler techniques has been limited by the relative insensitivity to low-velocity, low-amplitude flow states [8]. In particular, it can be very difficult, or even impossible, to differentiate ischemia from areas which appear poorly perfused with colour Doppler US [9,10], especially in elderly patients and in patients with underlying parenchymal disease [11].…”

Section: Introductionmentioning

confidence: 99%

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Value of contrast-enhanced ultrasonography for detecting renal infarcts proven by contrast enhanced CT. A feasibility study

et al. 2007

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The effectiveness of contrast-enhanced ultrasonography (CEUS) in the evaluation of patients with acute renal infarcts was investigated, using contrast-enhanced helical computed tomography (CT) as the reference imaging procedure. Twenty-seven consecutive patients with acute renal infarcts detected with contrast-enhanced helical CT underwent CEUS. Digital cine-clips of CEUS were evaluated by two independent readers blinded to CT findings. Image quality was rated subjectively on a four-point scale. Then, readers were asked to assign a confidence level in diagnosis of renal infarct at the upper pole, medium portion, and lower pole of each kidney according to a five-degree scale, ranging from definitely absent to definitely present. ROC curve analysis was employed to assess the overall confidence of diagnosis of infarct, and weighted kappa values were calculated to assess inter-reader agreement. The subjective image quality of CEUS was lower than the image quality of CT at the upper poles. However, the diagnostic performance of CEUS was excellent (area under receiver-operator characteristic curve 0.992 +/- 0.006 for reader 1; 0.991 +/- 0.007 for reader 2), with very good inter-reader agreement (weighted kappa value = 0.83). CEUS is a reproducible tool to detect acute renal infarcts in men, with a diagnostic performance approaching that of CT.

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Section: Introductionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Value of contrast-enhanced ultrasonography for detecting renal infarcts proven by contrast enhanced CT. A feasibility study

et al. 2007

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“…CEUS improves significantly the detection of non-perfused renal parenchymal zones appearing as single or multiple focal wedge-shaped areas of absent (Fig. 9), diminished, or delayed enhancement in comparison to the adjacent renal parenchyma [58,64]. Contrast-enhanced CT is still the reference imaging procedure for the diagnosis of acute pyelonephritis.…”

Section: Kidneysmentioning

confidence: 99%

Microbubble ultrasound contrast agents: an update

2007

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Microbubble contrast agents for ultrasound (US) have gained increasing interest in recent years, and contrast-enhanced US (CEUS) is a rapidly evolving field with applications now extending far beyond the initial improvements achieved in Doppler US. This has been achieved as a result of the safe profile and the increased stability of microbubbles persisting in the bloodstream for several minutes, and also by the availability of specialized contrast-specific US techniques, which allow a definite improvement in the contrast resolution and suppression of signal from stationary tissues. CEUS with low transmit power allows real-time scanning with the possibility of prolonged organ insonation. Several reports have described the effectiveness of microbubble contrast agents in many clinical applications and particularly in the liver, spleen, and kidneys. CEUS allows the assessment of the macrovasculature and microvasculature in different parenchymas, the identification and characterization of hepatic and splenic lesions, the depiction of septal enhancement in cystic renal masses, and the quantification of organ perfusion by the quantitative analysis of the echo-signal intensity. Other fields of application include the assessment of abdominal organs after traumas and the assessment of vesico-ureteral reflux in children. Finally, tumor-targeted microbubbles make possible the depiction of specific biologic processes.

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“…10) or other vascular abnormalities, the re-filling curve revealed an increased time-to-peak and reduced slope of the wash-in tract and maximum amplitude [49, [67][68][69][70]. Animal models were initially employed to assess the capabilities of CEUS in the detection of renal perfusion defects [71][72][73][74][75], which appear as single or multiple focal wedge-shaped areas of absent, diminished or delayed contrast enhancement in comparison to the adjacent renal parenchyma (Figs. 11, 12) [76,77].…”

Section: Clinical Applications Of Organ Perfusionmentioning

confidence: 99%