1995
DOI: 10.1128/jcm.33.1.79-84.1995
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Detection of foot-and-mouth disease virus-infected cattle by assessment of antibody response in oropharyngeal fluids

Abstract: The detection of foot-and-mouth disease virus (FMDV)-persistent carriers among convalescent ruminants is of paramount importance in the aftermath of a field outbreak. To this purpose, FMDV-specific antibody should be investigated first, since virus isolation procedures from such carriers are seriously constrained. The complexity of the overall picture may be compounded by possible emergency vaccinations in the affected areas at the beginning of the outbreak. In this case, it is suggested that mucosal rather th… Show more

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Cited by 35 publications
(15 citation statements)
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“…We have previously shown that pooled convalescent saliva and probang samples neutralized homologous FMDV infection of IB-RS-2 and BTY cells following depletion of IgG on a protein G column (data not shown). Several other studies have inferred that the neutralizing activity in mucosal secretions from FMD convalescent cattle is associated with IgA [15,24,25] and protection against reinfection with homologous FMDV has been shown to correlate with the presence of neutralizing IgA in probang samples [18]. Therefore, at least in in vitro assays, IgA has been shown to neutralize FMDV.…”
Section: Discussionmentioning
confidence: 99%
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“…We have previously shown that pooled convalescent saliva and probang samples neutralized homologous FMDV infection of IB-RS-2 and BTY cells following depletion of IgG on a protein G column (data not shown). Several other studies have inferred that the neutralizing activity in mucosal secretions from FMD convalescent cattle is associated with IgA [15,24,25] and protection against reinfection with homologous FMDV has been shown to correlate with the presence of neutralizing IgA in probang samples [18]. Therefore, at least in in vitro assays, IgA has been shown to neutralize FMDV.…”
Section: Discussionmentioning
confidence: 99%
“…Archetti and colleagues [25] have recently suggested that the detection of neutralizing antibody or FMDVspecific IgA in saliva and/or probang samples could be used to screen for cattle herds exposed to FMDV following ring-vaccination around an FMD outbreak. The findings reported here support the inclusion of testing for FMDV-specific IgA in serum in addition to mucosal fluid samples.…”
Section: Discussionmentioning
confidence: 99%
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“…This is the first description of a diagnostic assay to SBV based on saliva samples. To date most research on cattle saliva as a diagnostic sample has been carried out with regard to foot and mouth disease virus (FMDV) diagnostics [ 26 , 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…Mucosal IgA detection in oesophago-pharyngeal fluids had potential as an indicator of infection by foot and mouth disease virus in cattle [28][29][30]. Salivary total protein is a vital component of saliva with salivary protein; predominately comprising proline-rich protein, mucin, amylase, immunoglobulins, satherin and antibacterial factors, and these are responsible for most of functions of saliva [31].…”
Section: Introductionmentioning
confidence: 99%