Detection of free cancer cells in peritoneal cavity in patients surgically treated for gastric adenocarcinoma

Kostić, Zoran; Cuk, Vladimir; Bokun, Radojka; Ignjatovic, Dragan; Usaj-Knezevic, Slavica; Ignjatović, Mile

doi:10.2298/vsp0604349k

Cited by 16 publications

(9 citation statements)

References 34 publications

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“…In one of the earlier study, Kostić et al [8] showed that a tumor diameter >5 cm, tumor invasion of serosa, histopathological stage of the disease III and IV, and macroscopically visible metastases were the most important risk factors for detection of free cancer cells in patients surgically treated for gastric adenocarcinoma. The exact mechanism that was contributing to microscopic peritoneal carcinomatosis was still not clear.…”

Section: Discussionmentioning

confidence: 98%

Long-Term Results and Prognostic Factors of Gastric Cancer Patients with Microscopic Peritoneal Carcinomatosis

et al. 2012

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BackgroundClinical significance of microscopic peritoneal carcinomatosis remained unclear. The aim of this study was to evaluate the prognostic value of microscopic peritoneal carcinomatosis in gastric cancer.MethodsFrom 1996 to 2007, 4426 patients underwent gastrectomy for gastric cancer at Fudan University Shanghai Cancer Center. The clinical and pathological data were reviewed to identify patients with microscopic peritoneal carcinomatosis (group 1). The clinicopathological features and prognosis were examined. Additionally, 242 stage-matched gastric cancer patients without microscopic peritoneal carcinomatosis (group 2) and 118 with macroscopic peritoneal carcinomatosis (group 3) were selected as control groups.ResultsMicroscopic peritoneal carcinomatosis was found in 121 patients. There were 85 males and 36 females (2.36:1). There was a higher incidence rate of large size tumor (≥5 cm) (P = 0.045), Borrmann IV (P = 0.000), and serosal invasion (P = 0.000) in gastric cancer with microscopic peritoneal carcinomatosis compared with the control group. The 5-year survival rate of gastric cancer with microscopic peritoneal carcinomatosis was 24%, significantly poorer than that of the stage-matched control group but better than that of patients with macroscopic peritoneal carcinomatosis. The independent prognostic factors identified included pathological stage and operative curability.ConclusionsThe presence of microscopic peritoneal carcinomatosis was associated with worse prognosis for gastric cancer, but curative surgery showed potential to improve prognosis.

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Section: Discussionmentioning

confidence: 98%

Long-Term Results and Prognostic Factors of Gastric Cancer Patients with Microscopic Peritoneal Carcinomatosis

et al. 2012

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“…For the subgroup analysis, conventional cytology studies 1-3,12,16-19,24,49,54,79,94,96 (risk difference: 0.34; 95% CI: 0.2–0.48; n=2,373 patients; I 2 =93%; p <0.00001) and PCR-CEA 31,36,38,49,77,93,94,97,104 (risk difference: 0.5; 95% CI: 0.36–0.63; n=1,073 patients; I 2 =83%; p <0.00001) were reviewed by comparing stage III or IV patients with stage I or II patients.…”

Section: Resultsmentioning

confidence: 99%

“…For the subgroup analysis, conventional cytology studies 1-3,12,14,16,18,19,25,29,41,43,46,51,52,54-57,61,63,78,81,92,94,96, (risk difference: 0.25; 95% CI: 0.18–0.31; n=5,008 patients; I 2 =87%; p <0.00001) and PCR-CEA 31,36,38,48,57,58,64,76,77,93,94,97,101,104 (risk difference: 0.3; 95% CI: 0.15–0.45; n=1,464 patients; I 2 =93%; p <0.00001) were reviewed.…”

Section: Resultsmentioning

confidence: 99%

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Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Tustumi¹,

Bernardo²,

Dias³

et al. 2016

Clinics

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Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis. Databases were searched up to January 2016 for prognostic factors associated with intraperitoneal free cancer cells, including oncologic stage, depth of neoplasm invasion, lymph nodal spread, differentiation grade of the tumor, and recurrence and survival rates. A total of 100 studies were identified. Meta-analysis revealed a clear association between intraperitoneal free cancer cells and a poor prognosis. intraperitoneal free cancer cells -positive patients had higher rates of nodal spread (risk difference: 0.29; p<0.01), serosal invasion (risk difference: 0.43; p<0.01), recurrence (after 60 months of follow-up, risk difference: 0.44; p<0.01), and mortality (after 60 months of follow-up, risk difference: 0.34; p<0.01). Intraperitoneal free cancer cells are associated with a poor outcome in gastric cancer. This surrogate biomarker should be used to guide therapy both prior to and after surgery.

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“…Other means of peritoneal dissemination include iatrogenic or spontaneous perforation of the primary cancer 10 or embolism from transected lymphatics and blood vessels during the course of surgical resection 11 . Spread of the cancer cells in the peritoneal cavity has been shown to be dictated by gravity, peristaltic gastrointestinal movement, and the mechanics of the negative pressure generated by movement of the diaphragm.…”

Section: Introductionmentioning

confidence: 99%

Management of Peritoneal Carcinomatosis From Colorectal Cancer

Ihemelandu

Shen

Stewart

et al. 2011

Seminars in Oncology

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The management of peritoneal carcinomatosis from colorectal cancer is evolving. The introduction of new chemotherapeutic and biologic agents has certainly improved the outlook for many patients with metastatic colorectal cancer. Traditionally, patients with limited hepatic or pulmonary metastases were the only candidates for metastasectomy. However, patients with metastasis localized to the peritoneum have been shown to be candidates for metastasectomy with improved clinical outcomes. Cytoreductive surgery with the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) in this cohort of patients offers the only chance for long-term survival. Complete cytoreduction in combination with HIPEC for peritoneal surface disease has been demonstrated to produce survival outcomes similar to liver resection for hepatic metastases. This review will examine recent evidence pertaining to the evolving surgical oncology paradigm for management of colorectal peritoneal carcinomatosis.

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Detection of free cancer cells in peritoneal cavity in patients surgically treated for gastric adenocarcinoma

Cited by 16 publications

References 34 publications

Long-Term Results and Prognostic Factors of Gastric Cancer Patients with Microscopic Peritoneal Carcinomatosis

Long-Term Results and Prognostic Factors of Gastric Cancer Patients with Microscopic Peritoneal Carcinomatosis

Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Management of Peritoneal Carcinomatosis From Colorectal Cancer

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