Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

Motooka, Kei; Morishita, Koichi; Ito, Nami; Shinzaki, Shinichiro; Tashiro, Taku; Nojima, Satoshi; Shimizu, Kayoko; Date, Mutsuhiro; Sakata, Natsumi; Yamada, M.; Takamatsu, Shinji; Kamada, Y.; Iijima, Hideki; Mizushima, Tsunekazu; Morii, Eiichi; Takehara, Tetsuo; Miyoshi, Eiji

doi:10.3748/wjg.v27.i2.162

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Albumin–bilirubin (ALBI) score was calculated based on serum albumin and total bilirubin using the following formula: ALBI‐score = (log 10 bilirubin [μmol/L] × 0.66) + (albumin [g/L] × −0.085). Serum 10‐7G levels (10‐7G values) were determined using a lectin‐antibody ELISA kit 3 . The presence of infection with E. faecalis was evaluated using a CPS‐specific ELISA kit.…”

Section: Methodsmentioning

confidence: 99%

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Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy

et al. 2021

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Section: Methodsmentioning

confidence: 99%

“…Thus, advanced cirrhosis can be seen as the result of an inflammatory syndrome. Recently, we have established novel ELISA systems using glycan antibody 10‐7G mAb, which directly recognizes fucosylated haptoglobin (Fuc‐Hpt) as an index of intestinal inflammation 3 and using CPS antibody as an index of bacterial product translocation 4…”

Section: Introductionmentioning

confidence: 99%

Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy

et al. 2021

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“…Fucosylation is one of the most important glycosylation reactions involved in the progression of various types of cancer 7 . In our previous studies, lectin-antibody enzyme-linked immunosorbent assay (ELISA) was used to measure serum fucosylated haptoglobin (Fut-Hp) levels and revealed significantly increased serum Fut-Hp levels in several types of cancer and inflammatory bowel diseases 8 – 10 . Recent studies have highlighted the importance of fucosylation in immune cell development and functional regulation and have significantly broadened the role of fucosylation in cancer immunity and inflammatory diseases 8 , 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of serum fucosylated pro-haptoglobin in advanced renal cell carcinoma patients treated with immune checkpoint inhibitors

Kato,

Morishita,

Tomiyama

et al. 2023

Sci Rep

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With the widespread use of immune checkpoint inhibitors (ICIs), identifying predictive biomarkers is critical. Recently, serum fucosylated haptoglobin (Fuc-Hp) was thought to play an important role in tumour immunity in several types of cancer. Therefore, evaluating serum Fuc-Hp in the peripheral blood can potentially identify non-invasive predictive biomarkers for the clinical efficacy of ICIs. In this study, 31 patients with advanced renal cell carcinoma (RCC) treated with nivolumab were enrolled and defined as responders or non-responders according to RECIST criteria. Serum samples were collected before and 1 month after treatment initiation, and an ELISA assay was performed using Aleuria Aurantia Lectin (AAL) and 10-7G monoclonal antibodies that recognise Fuc-mature Hp (Fuc-mHp) and Fuc-pro Hp (Fuc-pHp), respectively. We first measured AAL-haptoglobin (Fuc-mHp) and total haptoglobin levels before nivolumab and found that neither value could predict the clinical response. Notably, serum 10-7G levels were significantly lower in the responder group (p = 0.035). We also confirmed the use of serum 10-7G levels for predicting progressive disease after nivolumab (area under the curve, 0.816). Accordingly, low 10-7G levels were significantly correlated with better progression-free survival (p = 0.041). In conclusion, serum Fuc-pHp analysis may identify patients with advanced RCC who benefit from ICIs.

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“…UC is an inflammatory bowel disease, a chronic condition, associated with modified gut microbiota, with unexplained causes [4,5]. It presents alternative periods of remission and relapse [6,7].…”

Section: Introductionmentioning

confidence: 99%

New Metabolic and Genetic Biomarkers for Diagnosis of Ulcerative Colitis

Tudoroniu¹,

Costache²,

Stancu³

et al. 2021

Preprint

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Ulcerative colitis (UC) is one of the two disorders known as inflammatory bowel diseases (IBD) along with Crohn’s disease (CD), with complex pathogenesis, requiring costly invasive investigations. Objective: to examine the most recent biomarkers proposed for UC diagnosis; to establish the strategy used to make the differential diagnosis between UC and CD relying on these biomarkers, also adding the benefit of finding new non-invasive tools in managing this condition. The search was performed in a single database (Web of Science) using the specific keywords &bdquo;ulcerative colitis”, &bdquo;biomarkers” and &bdquo;diagnosis” for the last five years. Study eligibility criteria: clinical trials on adults and pediatric patients with ulcerative colitis compared with Crohn’s disease. Results: We selected 57 studies, randomized controlled trials (RCTs) and clinical case series (CCS), summarizing the latest most specific biomarkers in diagnosis of UC. Limitations: we considered RCTs and CCS from one database, limited to the search topics. Our findings indicate a important number of potential biomarkers with diagnostic value, which bring the advantage of a non-invasive method to approach this challenging disorder.

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Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

Cited by 9 publications

References 29 publications

Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy

Rifaximin ameliorates intestinal inflammation in cirrhotic patients with hepatic encephalopathy

Prognostic significance of serum fucosylated pro-haptoglobin in advanced renal cell carcinoma patients treated with immune checkpoint inhibitors

New Metabolic and Genetic Biomarkers for Diagnosis of Ulcerative Colitis

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