After the M8.2 main-shock occurred on 7 September 2017 at the Isthmus of Tehuantepec, Mexico, the spatial distribution of seismicity has showed a clear clusterization of earthquakes along the collision region of the Tehuantepec Transform/Ridge with the Middle America Trench off Chiapas. Furthermore, nowadays, the temporal rate of occurrence in the number of earthquakes has also showed a pronounced increase. On the basis of this behavior, we studied the sequence of magnitudes of the earthquakes which occurred within the Isthmus of Tehuantepec in southern Mexico from 2010 to 2020. Since big earthquakes are considered as a phase transition, after the M8.2 main-shock, one must expect changes in the Tehuantepec ridge dynamics, which can be observed considering that the b-value in the Gutenberg–Richter law, has also showed changes in time. The goal of this paper is to characterize the behavior of the seismic activity by using the Gutenberg–Richter law, multifractal detrended fluctuation analysis, visibility graph and nowcasting method. Those methods have showed important parameters in order to assess risk, the multifractality and connectivity. Our findings indicate, first that b-value shows a dependency on time, which is clearly described by our analyses based on nowcasting method, multifractality and visibility graph.