Detection of glaucomatous retinal nerve fiber layer damage by scanning laser polarimetry with custom corneal compensation

Zhou, Qienyuan; Reed, Jerry; Betts, Ryan W.; Trost, P. K.; Lo, Pak-Wai; Wallace, Charles; Bienias, Richard H.; Li, Guoqiang; Winnick, Ross; Papworth, William A.; Sinai, Michael J.

doi:10.1117/12.477975

Cited by 27 publications

(42 citation statements)

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“…Note that the data were calculated from the thickness map, provided by the GDx, assuming a constant conversion factor of 0.67 nm/lm and an imaging wavelength of 785 nm. 5 It is worth noting here that the retardation values measured by the GDx-VCC were recorded at an imaging wavelength of 785 nm and that the PS-OCT retardation values were recorded at 840 nm. To compare the values correctly (retardation in degrees) provided by both systems, the GDx-VCC results were multiplied by a factor of 785/840.…”

Section: Resultsmentioning

confidence: 99%

“…9,31 The next post-processing step was to correct the polarization sensitive data for an influence of the birefringence of the anterior segment. While the GDx-VCC measures the anterior segment birefringence in the macula and adjusts a variable wave plate for correction, 5 we obtained the anterior birefringence data from a measurement of the polarization state at the retinal surface and used a software-based correction approach. 32 In a next step, we used the 3D polarization sensitive data to generate 2D en face maps of the RNFL retardation.…”

Section: Ps-oct Data Analysismentioning

confidence: 99%

“…4 2D-RNFL thickness maps are calculated by assuming a constant birefringence value of the RNFL. 5 Clinical suspicion of glaucoma is supported by comparing the individual measurement results with a normative database.…”

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confidence: 99%

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Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We presented a novel polarization sensitive optical coherence tomography (PS-OCT) system for measuring retinal nerve fiber layer (RNFL) birefringence, retardation, and thickness, and report on the repeatability of acquiring these quantities. METHODS.A new PS-OCT system, measuring at 840 nm, was developed that supports scan angles of up to 408 3 408 with an A-scan rate of 70 kHz. To test the performance and reproducibility, we measured 10 eyes of 5 healthy human volunteers five times each. All volunteers were imaged further with scanning laser polarimetry (SLP). The obtained RNFL birefringence, retardation, and thickness maps were averaged, and standard deviation maps were calculated. For quantitative comparison between the new PS-OCT and SLP, a circumpapillary evaluation within 2 annular segments (superior and inferior to the optic disc) was performed.RESULTS. High quality RNFL birefringence, retardation, and thickness maps were obtained. Within the superior and inferior segments, the mean retardation for individual eyes ranged from 208 to 28.98 and 17.28 to 28.28, respectively. The quadrant precision over the 5 consecutive measurements for each subject, calculated for the average retardation obtained within the superior and inferior quadrants ranged from 0.168 to 0.698. The mean birefringence ranged from 0.1068/lm to 0.1418/lm superior and 0.1018/lm to 0.1358/lm inferior, with a quadrant precision of 0.0018/lm to 0.0078/lm. The mean RNFL thickness varied from 114 to 150 lm superior, and 111 to 140.9 lm inferior (quadrant precision ranged from 3.6 to 11.9 lm). CONCLUSIONS.The new PS-OCT system showed high image quality and reproducibility, and, therefore, might be a valuable tool for glaucoma diagnosis. (Invest Ophthalmol Vis Sci. 2013; 54:72-84)

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Section: Resultsmentioning

confidence: 99%

Section: Ps-oct Data Analysismentioning

confidence: 99%

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Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Additional knowledge about light polarizing properties of tissues in health and disease can be obtained from preclinical research involving animals. Important information such as the conversion factor from birefringence to RNFL thickness via birefringence measurements in scanning laser polarimetry was obtained from animals and then translated to human imaging [58,59]. In a recent study, we used a PS-OCT system with lower resolution of 7.6 µm in air (5.6 µm in tissue) to study birefringence in the peripapillary rat sclera in vivo [33].…”

Section: Discussionmentioning

confidence: 99%

Polarization properties of single layers in the posterior eyes of mice and rats investigated using high resolution polarization sensitive optical coherence tomography

Fialová¹,

Augustin²,

Glösmann³

et al. 2016

Biomed. Opt. Express

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Abstract:We present a high resolution polarization sensitive optical coherence tomography (PS-OCT) system for ocular imaging in rodents. The system operates at 840 nm and uses a broadband superluminescent diode providing an axial resolution of 5.1 µm in air. PS-OCT data was acquired at 83 kHz A-scan rate by two identical custom-made spectrometers for orthogonal polarization states. Pigmented (Brown Norway, Long Evans) and non-pigmented (Sprague Dawley) rats as well as pigmented mice (C57BL/6) were imaged. Melanin pigment related depolarization was analyzed in the retinal pigment epithelium (RPE) and choroid of these animals using the degree of polarization uniformity (DOPU). For all rat strains, significant differences between RPE and choroidal depolarization were observed. In contrast, DOPU characteristics of RPE and choroid were similar for C57BL/6 mice. Moreover, the depolarization within the same tissue type varied significantly between different rodent strains. Retinal nerve fiber layer thickness, phase retardation, and birefringence were mapped and quantitatively measured in Long Evans rats in vivo for the first time. In a circumpapillary annulus, retinal nerve fiber layer birefringence amounted to 0.16°/µm ± 0.02°/µm and 0.17°/µm ± 0.01°/µm for the left and right eyes, respectively. 934-936 (1997). ©2016 Optical Society of America

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“…Methods for AS compensation used in the past have included external polarization elements to "neutralize" the ASR so that it does not appear in the dataset (GDx [169] and GDx-VCC [195]), and mathematical methods to extract the ASR from the dataset after it has been collected (GDx-ECC [181]). Given that ASR is by design incorporated into GDx-MM data, and given that a direct measurement of ASR (for example by viewing the fourth Purkinje image) is not possible here, it is necessary to estimate the ASR and then extract it as a post-processing step.…”

Section: Set 5: Spectralonmentioning

confidence: 99%

GDx-MM: An Imaging Mueller Matrix Retinal Polarimeter

Twietmeyer

2007

Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion

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Detection of glaucomatous retinal nerve fiber layer damage by scanning laser polarimetry with custom corneal compensation

Cited by 27 publications

References 0 publications

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Polarization properties of single layers in the posterior eyes of mice and rats investigated using high resolution polarization sensitive optical coherence tomography

GDx-MM: An Imaging Mueller Matrix Retinal Polarimeter

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