1999
DOI: 10.1002/(sici)1522-2594(199908)42:2<283::aid-mrm10>3.0.co;2-q
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Detection of glutathione in the human brain in vivo by means of double quantum coherence filtering

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Cited by 97 publications
(105 citation statements)
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“…To assess whether NAC elevates GSH levels in the brain of schizophrenia patients, in vivo magnetic resonance spectroscopy (MRS) would be necessary. However, it has been reported that with current MRS methods, the signal-to-noise ratio would need to be improved to observe discrete increases in brain GSH levels (Trabesinger et al, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…To assess whether NAC elevates GSH levels in the brain of schizophrenia patients, in vivo magnetic resonance spectroscopy (MRS) would be necessary. However, it has been reported that with current MRS methods, the signal-to-noise ratio would need to be improved to observe discrete increases in brain GSH levels (Trabesinger et al, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…As demonstrated, the double-quantum coherence filtering technique provides excellent discrimination between the cysteinyl compound of GSH and creatine (1). Signal from the strongly coupled ABX-spin system of aspartate leaks through the filter but may be separated from the GSH contribution due to the difference in chemical shift.…”
Section: In Ref 1)mentioning
confidence: 99%
“…All spectra were acquired using the same phase-cycle scheme as in Ref. 1. After acquisition, the time signals were DC corrected, zero-filled to 4096 points and multiplied with an exponential function corresponding to a line broadening of 1.5 Hz.…”
Section: In Vitro and In Vivo Studiesmentioning
confidence: 99%
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“…In comparison, the GABA signal measured by spectrally nonor semiselective methods could contain a significant amount of coedited macromolecules. There is also in vivo evidence of a possibly significant presence of glutathione in the human cortex (17,18). The cysteinyl CH 2 group of glutathione resonates at 2.87-2.94 ppm.…”
mentioning
confidence: 99%