Detection of Gluten Immunogenic Peptides in Feces and Urine in Patients with Celiac Disease on a Gluten-Free Diet

Sugai, Emilia; Costa, Ana Luiza Fontes de Azevedo; Temprano, Ma. de la Paz; Niveloni, Sonia I.; Smecuol, Edgardo; Vázquez, Horacio; Dodds, Samanta; Moreno, María Laura; Selvino, María Victoria; Mazure, Selvino M.; Muñoz-Suano, Alba; Gonzalez, Andrea F.; Domínguez, Remedios; Verdú, Elena F.; Ramirez, Angel Cebolla; Mauriño, Eduardo; Bai, Julio C.

doi:10.1016/s0016-5085(17)30866-1

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“…The level of tTG had prolonged response to gluten intake, both for elevation and decreasing. Even though the GIP test seems to be much more sensitive as compared to serological tests because the response is immediate, not prolonged in time, the one limitation is that it informs only about the intake of gluten up to 72 h after the incidence [ 40 ]. Therefore, GIP would have to be analyzed very frequently to confirm if gluten was ingested voluntarily or accidentally and in combination to serological tests informing about long-term diet routine.…”

Section: Resultsmentioning

confidence: 99%

Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet—Results of a Randomized, Placebo-Controlled, Pilot Trial

2020

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Abnormalities in the intestinal barrier are a possible cause of celiac disease (CD) development. In animal studies, the positive effect of prebiotics on the improvement of gut barrier parameters has been observed, but the results of human studies to date remain inconsistent. Therefore, this study aimed to evaluate the effect of twelve-week supplementation of a gluten-free diet (GFD) with prebiotic oligofructose-enriched inulin (10 g per day) on the intestinal permeability in children with CD treated with a GFD. A pilot, randomized, placebo-controlled nutritional intervention was conducted in 34 children with CD, being on a strict GFD. Sugar absorption test (SAT) and the concentrations of intestinal permeability markers, such as zonulin, intestinal fatty acid-binding protein, claudin-3, calprotectin, and glucagon-like peptide-2, were measured. We found that the supplementation with prebiotic did not have a substantial effect on barrier integrity. Prebiotic intake increased excretion of mannitol, which may suggest an increase in the epithelial surface. Most children in our study seem to have normal values for intestinal permeability tests before the intervention. For individuals with elevated values, improvement in calprotectin and SAT was observed after the prebiotic intake. This preliminary study suggests that prebiotics may have an impact on the intestinal barrier, but it requires confirmation in studies with more subjects with ongoing leaky gut.

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Section: Resultsmentioning

confidence: 99%