Detection of heart transplant rejection by doppler tissue imaging

Puleo, John A.; Weston, Mark; French, M; Cintrón, Guillermo; Davis, Mitchell G.; Fontanet, Hector L.

doi:10.1016/s0735-1097(96)80688-7

Cited by 16 publications

(22 citation statements)

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“…The first systolic (Sw), early diastolic (Ew), and late diastolic (Aw) tissue Doppler velocities were measured at the lateral mitral wall and averaged over 3 cycles in accordance with previous reports. [5][6][7][8][9][10][11][12][13][14] These echocardiographic evaluations were done in week 1 (before starting IVIG therapy), week 2 (≈7 days after starting IVIG therapy), week 3 (≈14 days after starting IVIG therapy), and in the convalescent stage (a mean of 5, 12, 19, and 36 days after onset). All patients agreed to initial echocardiographic evaluations before starting IVIG therapy in week 1.…”

Section: Echocardiographymentioning

confidence: 99%

“…4 Several recent studies have discussed the usefulness of tissue Doppler imaging (TDI) to evaluate left ventricular (LV) function. [5][6][7][8][9][10][11][12][13][14] Tissue Doppler measurement of myocardial Doppler velocity can be used to measure long-axis functions, which seem to be both more sensitive to minor disturbances in LV function and relatively preload-independent. 11,[13][14] In the present study we used TDI to evaluate disturbance of myocardial function in acute KD patients.…”

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confidence: 99%

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Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease

Takeuchi

Saji

Takatsuki

et al. 2007

Circ J

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awasaki disease (KD) is a systemic vasculitis that primarily affects small and medium-sized arteries. 1 Transient myocardial dysfunction in children with acute KD has been reported 2,3 and moreover, myocardial inflammation, including myocarditis and microvascular damage in the myocardium, has been shown to cause aberrations in cardiac function. 4 Several recent studies have discussed the usefulness of tissue Doppler imaging (TDI) to evaluate left ventricular (LV) function. [5][6][7][8][9][10][11][12][13][14] Tissue Doppler measurement of myocardial Doppler velocity can be used to measure long-axis functions, which seem to be both more sensitive to minor disturbances in LV function and relatively preload-independent. 11,[13][14] In the present study we used TDI to evaluate disturbance of myocardial function in acute KD patients. Circulation Journal Vol.71, March 2007The plasma brain natriuretic peptide (BNP) level is associated with cardiac function in adult patients with congestive heart failure. 15,16 Although elevation of BNP has been reported in acute KD patients,17 no relation between BNP and cardiac function has been found.Reports have suggested that increased systemic oxidative stress is associated with progression of cardiovascular disease, including ischemia -reperfusion injury, atherosclerosis, and heart failure. [18][19][20][21][22][23][24] The isoprostanes are a complex family of compounds produced from arachidonic acid via a free radical-catalyzed mechanism. 18,19 The level of 8-isoprostane is used as a pathophysiological marker of lipid peroxidation. We previously reported elevation of urinary 8-isoprostane levels in acute KD patients, 25 and although the exact pathological role of increased oxidative stress in acute KD is uncertain, we believe that it is associated with oxidative injury to systemic vessels. 25 We hypothesize that this combined with disturbance of myocardial microcirculation may contribute to myocardial dysfunction in acute KD. Therefore, the purpose of the present study was to investigate the relationship between abnormal myocardial performance and plasma BNP levels, and to investigate the association between abnormal myocardial performance and enhanced oxidative stress. Background The aims of this study were to evaluate myocardial mechanics using pulsed tissue Doppler imaging (TDI), and to determine the relationship between abnormal myocardial performance and plasma brain natriuretic peptide (BNP) levels and oxidative stress in acute Kawasaki disease (KD). Methods and ResultsConsecutive TDI parameters, including peak systolic velocity (Sw) and early (Ew) and late diastolic excursion of the mitral annuli were obtained in 42 patients with KD (mean age: 2.4±0.4 years) in weeks 1, 2, and 3, and during convalescence. Plasma BNP level and urinary 8-isoprostane were also examined during the acute phase. These data were then compared with TDI profiles from 62 healthy children, plasma BNP levels in 38 controls with other febrile illnesses, and urinary 8-isoprostane levels in 13 healthy chi...

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Section: Echocardiographymentioning

confidence: 99%

mentioning

confidence: 99%

Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease

Takeuchi

Saji

Takatsuki

et al. 2007

Circ J

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“…Diastolic dysfunction accounts for up to half of all heart-failure cases (1). Many experimental studies suggest that regional myocardial relaxation disorders are related to specific cardiac diseases, such as ischemic or hypertrophic cardiomyopathy and LV hypertrophy (2)(3)(4)(5)(6).…”

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confidence: 99%

Detailed analysis of myocardial motion in volunteers and patients using high‐temporal‐resolution MR tissue phase mapping

Jung

Föll

Böttler

et al. 2006

Magnetic Resonance Imaging

100

115

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Purpose: To detect and investigate details in left ventricular (LV) motion patterns with a temporal resolution comparable to that of echocardiography. Material and Methods:To assess global and regional myocardial motion in high temporal detail, respiratory-gated MR phase-contrast measurements with three-directional velocity encoding (venc) were performed in 12 healthy volunteers and two patients with LV hypertrophy in basal, midventricular, and apical locations of the LV with a temporal resolution of 13.8 msec. Results:The volunteer data revealed details in LV motion patterns that were known only from echocardiography. For all volunteers, characteristic myocardial motion patterns, such as triphasic global diastolic expansion, could be detected with high accuracy. One volunteer underwent an additional echocardiographic measurement in order to corroborate the complex motion features as measured by MRI. Patient examinations revealed substantial changes in diastolic function compared to motion patterns in healthy volunteers. Conclusion:The proposed high-temporal-resolution velocitymapping technique provides previously undetectable information on LV performance, and is highly promising for the detection of local and global motion abnormalities in patients with disturbed LV performance, such as diastolic dysfunction.

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“…Regarding our study, we supposed that the a'LAT variable was useful to establish the occurrence of CR ≥ 3A and this parameter does not appear to be under the influence of prior alterations in diastolic function. Other observational studies did not analyze a' waves and found significant variations in S and e' waves 8,26 . Tissue Doppler parameters (mitral and tricuspid e'/e' ratios have been reported as non-invasive measures to rule out transplant rejection in pediatric heart transplant recipients 26 .…”

Section: Evolutive Phase Studymentioning

confidence: 97%

“…As left ventricular diastolic dysfunction is an early event during allograft rejection, this technique may be useful to detect rejection non-invasively 6 . However, the role of TDI in the evaluation of subjects after heart transplantation (HT) and for the diagnosis of CR remains unclear [7][8][9] . Thus, the purpose of this study was to investigate TDI abnormalities in myocardial relaxation and contraction velocities in HT patients, and also to analyze the additional TDI diagnostic information compared to conventional Doppler concerning significant CR.…”

Section: Introductionmentioning

confidence: 99%

Ecocardiografia por Doppler tecidual no diagnóstico de rejeição após transplante cardíaco

Resende¹,

Vieira²,

Bacal³

et al. 2011

Arq. Bras. Cardiol.

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Detection of heart transplant rejection by doppler tissue imaging

Cited by 16 publications

References 0 publications

Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease

Abnormal Tissue Doppler Images are Associated With Elevated Plasma Brain Natriuretic Peptide and Increased Oxidative Stress in Acute Kawasaki Disease

Detailed analysis of myocardial motion in volunteers and patients using high‐temporal‐resolution MR tissue phase mapping

Ecocardiografia por Doppler tecidual no diagnóstico de rejeição após transplante cardíaco

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