Detection of Helicobacter pylori CagA EPIYA in gastric biopsy specimens and its relation to gastric diseases

Vianna, Júlia Silveira; Ramis, Ivy Bastos; Halicki, Priscila Cristina Bartolomeu; Gastal, Otávio Leite; Silva, Renato Azevedo da; Salomão, José; Santos, Deise Machado dos; Chaves, Ana Lúcia; Juliano, Carlos Renan Varela; Jannke, Heitor Alberto; Silva, Lande Vieira da; Groll, Andréa von; Silva, Pedro Eduardo Almeida da

doi:10.1016/j.diagmicrobio.2015.05.017

Cited by 13 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, 23 full-text articles that met the inclusion criteria were included in this meta-analysis. [24–29,36–53] Among these articles, 7 (8 studies) compared 1 EPIYA-C with 1 EPIYA-D site (6 studies: PUD vs gastritis/FD; 3 studies: GU vs gastritis/FD; 3 studies: DU vs gastritis/FD; 7 studies: GC vs gastritis/FD). Additionally, 19 articles (19 studies) compared no more than 1 EPIYA-C with multiple EPIYA-C sites (15 studies: PUD vs gastritis/FD; 5 studies: GU vs gastritis/FD; 9 studies: DU vs gastritis/FD; 14 studies: GC vs gastritis/FD).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks

Liu

Gong

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…For example, Vianna et al [24] analyzed the association between H pylori strains with multiple EPIYA-C sites and PUD and compared that to H pylori strains with no more than 1 EPIYA-C motif. The authors observed that multiple C sites were associated with increased PUD risk.…”

Section: Introductionmentioning

confidence: 99%

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks

Liu

Gong

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…17,23 Another study even indicated a lower prevalence of 40.8%. 24 In this study, we found significant association between H. pylori infection and the severity of endoscopic appearances (OR = 2.67; 95% CI = 1.18-6.05). This result was in accordance with the available literature.…”

Section: Discussionmentioning

confidence: 65%

“…However, they found that the prevalence of peptic ulcer was more common in CagA EPIYA-ABCC/ABCCC strain compared to CagA EPIYA-ABC strain. 24 This showed that microbial virulence was not only determined by the presence of CagA gene, but also by the role of EPIYA motif in the CagA gene.…”

Section: Discussionmentioning

confidence: 99%

Detection of Helicobacter pylori CagA gene and Its Association with Endoscopic Appearance in Balinese Dyspepsia Patients

Mariadi

Wibawa

2017

InaJGHE

View full text Add to dashboard Cite

show abstract

“…42 Also, it was observed that infection by cagA-positive H. pylori strains harboring multiple EPIYA-C repeats is associated with the presence of peptic ulcer. 43 Another important disease-associated pathogenicity genes of H. pylori are vacA, iceA and babA.…”

Section: Influence Of Cytokines Genes Polymorphisms In the Gastric DImentioning

confidence: 99%

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

Vianna¹,

Silva²,

Ramis³

2016

Rev Epidemiol Control Infect

Self Cite

View full text Add to dashboard Cite

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. pylori possui um conjunto de fatores de patogenicidade, tais como cagA, vacA, iceA, babA, para colonizar a mucosa gástrica e estabelecer infecção crônica. Estes fatores bacterianos são agentes essenciais em modular a resposta imune envolvida na iniciação da carcinogênesegástrica. Os fatores genéticos do hospedeiro contribuem para regular a resposta inflamatória e para o agravamento da lesão da mucosa gástrica uma vez que a infecção gástrica por H. pylori induz a produção de várias citocinas pró e anti-inflamatórias no hospedeiro. O papel prejudicial dos fatores ambientais está relacionado com as precárias condições socioeconômicas, com o consumo de sal, com o tabagismo e com o consumo de álcool. Conclusão: Ao decifrar as regras deterministas -se houver -dessa interação entre fatores da bactéria, do hospedeiro e variáveis ambientais, será possível prever, tratar e, finalmente, prevenir graves doenças gastroduodenais. Background and Objectives:Helicobacter pylori is a Gram-negative bacterium that colonizes the stomach of approximately 50% of the world´s human population. This microorganismis the major causal agent of gastritis and is an important risk factor for the development of peptic ulcer disease and gastric carcinoma. The factors that determine these diverse clinical outcomes are subject to continuous investigations and is thought to be determined by interaction of bacterial factors, host immune system and environmental variables. The aim of this review is to provide an overview of these factors that influence susceptibility to severe outcomes of H. pylori

show abstract

Detection of Helicobacter pylori CagA EPIYA in gastric biopsy specimens and its relation to gastric diseases

Cited by 13 publications

References 35 publications

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks

Detection of Helicobacter pylori CagA gene and Its Association with Endoscopic Appearance in Balinese Dyspepsia Patients

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

Contact Info

Product

Resources

About