Detection of Helicobacter Pylori in Nasal Polyps: An Epidemiological Study

Abstract

Many studies have described the detection of Helicobacter pylori (HP) in the nasal polyps; however, although gastroesophageal reflux has been associated with chronic rhinosinusitis and nasal polyps development, the role of HP remains unclear. Our aim was to describe the prevalence of HP detection in nasal polyps and its association with gastric HP infection and gastroesophageal reflux dsease (GERD). The prospective study involved 36 patients with nasal polyps, who underwent to endoscopic surgery removal of nasal polyps. Before surgical procedure all patients were tested for gastric HP infection by 13 C-urea breath test, while tissue samples from nasal polyps were tested for HP detection, using rapid urease test (CLO test) and histological examination with Giemsa stain. All patients were asked about GERD-related symptoms. HP in nasal polyps was detected in 9 out of 36 patients (25%) using histological examination with Giemsa stain, while the detection rate of HP was 30.5% (11/36) using CLO test. Furthermore, 28 out of 36 patients (77.7%) had gastric HP infection. All patients with HP colonization in nasal polyps had gastric HP infection and all patients with HP in nasal polyps reported symptoms related to GERD. HP was detected in approximately one out of three patients in nasal polyps, while all patients with HP detection in nasal polyps had concurrently gastric HP infection and reported GERD-related symptoms, suggesting a gastro-nasal route of HP.

Gastroesophageal Reflux Disease and Rhinosinusitis: A Bidirectional Mendelian Randomization Study

“…Intranasal infection with Helicobacter Pylori (H. Pylori) has also been reported to be a pivotal factor in causing CRS and nasal polyps. Approximately 28.9-40% of CRS patients have H. Pylori colonization in nasal polyp tissue, and almost all patients with intranasal H. Pylori infection suffer from gastric H. Pylori infection with GERDassociated symptoms [24][25][26]. Apart from the infectious factor, gastroesophageal reflux leads to vagusmediated neuroinflammatory alterations that might exert potential effects on the development of CRS.…”

Multidisciplinary Approach To The Problem Of Managing Children With Frequent Respiratory Infections Of The Upper Respiratory Tract: Key Results

“…Также обсуждается роль Helicobacter pylori в патогенезе рецидивирующей патологии верхних дыхательных путей. Микроорганизм обнаруживается не только в желудке, но и в слизистой оболочке полости рта и носа, в полипах носа [9,10], а также у пациентов, страдающих как ГЭРБ, так и хроническим риносинуситом. Более того, H. pylori вызывает системное воспаление с последующим угнетением мукоцилиарного клиренса слизистой оболочки полости носа, что играет важную роль в патогенезе хронического риносинусита [11].…”