Detection of hemoglobin in blood and urine glucose level samples using a graphene-coated SPR based biosensor

Mostufa, Shahriar; Paul, Alok Kumar; Chakrabarti, Kisalaya

doi:10.1364/osac.433633

Cited by 90 publications

(42 citation statements)

References 49 publications

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“…Generally, physisorption occurs when the pristine 2D materials are adopted as the substrate material for molecule adsorption. The introduction of defects, doping with foreign materials, heterostructure formation, etc., create more active sites on the surface than its perfect structure [ 185 , 186 , 187 , 188 ]. In addition, the tuning can cause a sudden change in the electronic states of the 2D material, which promotes the sensing mechanism [ 189 ].…”

Section: Theoretical Perspective For Glucose Sensing By 2d Materialsmentioning

confidence: 99%

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials

et al. 2022

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Diabetes is a health disorder that necessitates constant blood glucose monitoring. The industry is always interested in creating novel glucose sensor devices because of the great demand for low-cost, quick, and precise means of monitoring blood glucose levels. Electrochemical glucose sensors, among others, have been developed and are now frequently used in clinical research. Nonetheless, despite the substantial obstacles, these electrochemical glucose sensors face numerous challenges. Because of their excellent stability, vast surface area, and low cost, various types of 2D materials have been employed to produce enzymatic and nonenzymatic glucose sensing applications. This review article looks at both enzymatic and nonenzymatic glucose sensors made from 2D materials. On the other hand, we concentrated on discussing the complexities of many significant papers addressing the construction of sensors and the usage of prepared sensors so that readers might grasp the concepts underlying such devices and related detection strategies. We also discuss several tuning approaches for improving electrochemical glucose sensor performance, as well as current breakthroughs and future plans in wearable and flexible electrochemical glucose sensors based on 2D materials as well as photoelectrochemical sensors.

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Section: Theoretical Perspective For Glucose Sensing By 2d Materialsmentioning

confidence: 99%

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials

et al. 2022

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“…For each 0.001 change in the refractive index, 6.1025 𝑔/𝑙 increment factor in the blood has been observed due to the presence of hemoglobin [34]. For each hemoglobin level, the values calculated for change in minimum reflectance (𝛥𝑅) and incidence angle with observed sensitivities has been tabulated in Table 4.…”

Section: Hemoglobin Detection In Blood Samplesmentioning

confidence: 99%

Monitoring hemoglobin levels in human blood samples using an MXene-ZnO-graphene based Surface plasmon resonance biosensor

Manavalan

Kuppusamy

Uniyal

et al. 2022

Preprint

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The main aim of our present study is to propose a surface plasmon resonance-based biosensor design for hemoglobin concentration monitoring in human blood samples. The proposed SPR sensor is based upon the Kretschmann configuration with silver metal, MXene, ZnO, and graphene nanolayers, with a BK7 coupling prism. A He-Ne laser optical input source with a 633 nm wavelength is used following the attenuated total reflection (ATR) principle. After employing the MXene, ZnO, and graphene layers over the conventional sensor setup, an investigation is done. With the optimized structure, our main aim is to detect the presence of hemoglobin concentration in the human blood with its refractive index variation. The calculated highest sensitivity of the proposed configuration is 154 \(Degree/RIU\) with the other parameters calculated as FWHM near \(3.69 Degree\), SNR of 0.5051 \({\text{D}\text{e}\text{g}\text{r}\text{e}\text{e}}^{-1}\) and quality factor of 41.58 \({RIU}^{-1}\).

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“…These values were used for analysis using COMSOL Multiphysics software and plotted using MATLAB software. Urine samples were analyzed by monitoring the SPR angle shift, and for a 0.001 refractive index change, the angular shift sensitivity was found to be 200 deg/RIU [ 93 ]. This multilayered–multianalyte detection SPR-based sensor can pursue a practical application in the bedside, remote monitoring blood hemoglobin levels and urine glucose simultaneously.…”

Section: Optoelectronic Biosensorsmentioning

confidence: 99%

“…A monochromatic light source with a wavelength of 628.8 nm is applied to BK 7 with a 60 deg to 89 deg angular range and the detector measures the sensor sensitivity based on the shifting of dip in reflectance intensity (%) based on variation in the refractive indices of blood and urine samples. Image reproduced with permission from [ 93 ], Copyrights (2021), Optical Society of America under the terms of the OSA Open Access Publishing Agreement. ( B ) Photographic representation of the multifunctional smart textile showing the LPS-POF sensor placement and schematic representation of the acquisition matrix due to sensor responses.…”

Section: Optoelectronic Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

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In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

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Detection of hemoglobin in blood and urine glucose level samples using a graphene-coated SPR based biosensor

Cited by 90 publications

References 49 publications

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials

Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials

Monitoring hemoglobin levels in human blood samples using an MXene-ZnO-graphene based Surface plasmon resonance biosensor

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

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