Detection of Hepatitis B Virus (HBV) Genotype E Carried—Even in the Presence of High Titers of Anti-HBs Antibodies—by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV

Mathet, Verónica Lidia; Cuestas, María Luján; Ruiz, Vanesa; Minassian, María Laura; Rivero, Cintia W.; Trinks, Julieta; Daleoso, Graciela; León, Liliana; Sala, Andrea; Libellara, Beatriz; Corach, Daniel; Oubiña, José R.

doi:10.1128/jcm.00866-06

Cited by 34 publications

(33 citation statements)

References 22 publications

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“…The amino acid residues from positions 120 to 123 were considered to be essential for the antigenicity of HBsAg in previous studies (26). Mutants with mutations from aa 144 to aa 148, such as G145R and D144A, were reported to be the common escape mutants that interfered with HBsAg detection and/or mutants that evaded vaccineinduced neutralizing antibodies (5,20). Thus, mutations in these two regions may have played a crucial role in the occurrence of OBIs.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Yuan

Chen

et al. 2010

J Clin Microbiol

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Section: Discussionmentioning

confidence: 99%

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Yuan

Chen

et al. 2010

J Clin Microbiol

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“…To date, there are no reports referring to these mutants in other parts of the world. The following are among the S-mutants reported in Argentina C69Y, C90Y, L110I, T114A, C124R, C124Y, C138R, N129R, C139R, S140T, L158F, A168T, C176R, N178S [34]; S45A, P46H, L49H, C107R, T125A, M133K, I152F, P153T, Y161S, G185E, A194T,G202R, I213L [30]; D144A, L209V [8].…”

Section: Current Prevalence Of S-escape Mutantsmentioning

confidence: 87%

“…Some reports from Argentina have recently documented the emergence of S-immune escape mutants in spite of the presence of usually protective anti-HBs antibodies [8,20,21,30,34,56,57] and of cytotoxic T lymphocyte-specific clones [30]. Some of them occurred naturally in HBV-chronically infected patients while others are the result of selected immunological pressures upon vaccination.…”

Section: Current Prevalence Of S-escape Mutantsmentioning

confidence: 99%

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Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Maria¹

2015

JHVRV

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Despite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection remains a major health care problem. More than 240 million people are chronically infected worldwide showing differences in the severity of liver disease, clinical outcome and response to immune-and antiviraltherapy. Parameters associated with the host immune system (HBV specific Tand/or B-cell repertoires, defective antigen presentation and diminished Th1/ Th2 response ratio) and viral factors such as the HBV genotypes and their evolving variants/mutants, have largely contributed to explaining such differences. The unique genomic structure and replication cycle of HBV provide much opportunity for mutations to occur in any of its genes undergoing selection pressures, such as those associated with the host immune system, the hepatitis B vaccine and/ or hepatitis B immune globulin and the antiviral therapy with nucleos(t)ide analogues. Firstly, this review describes the current prevalence of S-escape mutants worldwide. Secondly, the clinical implications of such surface gene variants and the impact of universal hepatitis B vaccination on HBV mutations and genotypes are discussed. Finally, the fact that the immune escape process also extends well beyond HBV is addressed.

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“…This genotype has never been reported in Brazil. It was recently found in 2 Argentinian sisters whose mother is from the Dominican Republic (19). In Brazil, genotypes A, B, C, D, and F have already been described and their distribution varies among Brazilian regions (4,10,20), suggesting an influence of the immigration pattern for each region.…”

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Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler

Sitnik

Sette

Santana

et al. 2007

Braz J Med Biol Res

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Genotype E of hepatitis B virus (HBV) has not been described in Brazil and is found mainly in Africa. Genotype A is the most prevalent in Brazil, and genotypes B, C, D, and F have already been reported. We report here an HBV genotype E-infected patient and some characterization of surface (S) protein, DNA polymerase (P) and precore/ core (preC/C) coding regions based on the viral genome. The patient is a 31-year-old black man with chronic hepatitis B who was born and raised in Angola. He has been followed by a hepatologist in São Paulo, Brazil, since November 2003, and he is a frequent traveler to Latin America, Africa, and Europe. In 2003, he was diagnosed with HBV infection and started treatment with lamivudine with the later addition of adefovir dipivoxil. No known risk factor was identified. Serologically, he is HBsAg and anti-HBe positive, but HBeAg and anti-HBs negative. DNA sequence analysis of the S/P region confirmed that this patient is infected with genotype E, subtype ayw4. The preC/C region showed G1896A and G1899A mutations but no mutations in the basal core promoter. Nucleotide substitutions common in genotype E were also observed (C1772, T1858 and A1757). Although this is not an autochthonous case and there is no evidence of further spread, the description of this case in Brazil highlights the current risk of viral genotypes spreading with unprecedented speed due to constant travel around the world. Key wordsHepatitis B virus (HBV) is a major cause of chronic liver disease worldwide. This virus is a small DNA virus with a partially double-stranded 3.2-kb genome (1) and has been classified into eight genotypes (A-H) based on sequence divergence over the entire genome. The genotypes show a distinct and well-defined geographic distribution (2).

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Detection of Hepatitis B Virus (HBV) Genotype E Carried—Even in the Presence of High Titers of Anti-HBs Antibodies—by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV

Abstract: Genotype E hepatitis B virus (HBV) was detected in two

Cited by 34 publications

References 22 publications

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China

Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler

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