Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues

Nagao, Yumiko; Sata, Michio; Noguchi, Seiichiro; Seno'O, Tamiko; Kinoshita, Moritoshi; Kameyama, Tadamitsu; Ueno, Takato

doi:10.1034/j.1600-0714.2000.290604.x

Cited by 110 publications

(95 citation statements)

References 35 publications

(43 reference statements)

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“…Pilli et al [96] detected HCV-specific T cells with phenotypic and functional characteristics of terminally differentiated effector cells at the site of the oral lesions. These findings and the detection of HCV RNA strands in the lichen tissue [97] suggests a possible role for HCVspecific T-cell responses in the pathogenesis of lichen planus associated with HCV infection [98] . Our study has demonstrated a high prevalence of extrahepatic manifestations in Bulgarian patients with chronic HCV infection.…”

Section: Discussionmentioning

confidence: 80%

Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients

Stefanova-Petrova¹,

Tzvetanska²,

Naumova³

et al. 2007

WJG

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AIM: To a s s e s s t h e p r e va l e n c e o f e x t ra h e p a t i c manifestations in Bulgarian patients with chronic hepatitis C virus (HCV) infection and identify the clinical and biological manifestations associated with cryoglobulinemia. METHODS:The medical records of 136 chronically infected HCV patients were reviewed to assess the prevalence of extrahepatic manifestations. Association between cryoglobulin-positivity and other manifestations were identified using χ 2 and Fisher's exact test. Risk factors for the presence of extrahepatic manifestations were assessed by logistic regression analysis. RESULTS:Seventy six percent (104/136) of the patients had at least one extrahepatic manifestation. Clinical manifestations included fatigue (59.6%), kidney impairment (25.0%), type 2 diabetes (22.8%), paresthesia (19.9%), arthralgia (18.4%), palpable purpura (17.6%), lymphadenopathy (16.2%), pulmonary fibrosis (15.4%), thyroid dysfunction (14.7%), Raynaud's phenomenon (11.8%), B-cell lymphoma (8.8%), sicca syndrome (6.6%), and lichen planus (5.9%). The biological manifestations included cryoglobulin production (37.5%), thrombocytopenia (31.6%), and autoantibodies: anti-nuclear (18.4%), anti-smooth muscle (16.9%), anti-neutrophil cytoplasm (13.2%) and anti-cardiolipin (8.8%). All extrahepatic manifestations showed an association with cryoglobulin-positivity, with the exception of thyroid dysfunction, sicca syndrome, and lichen planus. Risks factors for the presence of extrahepatic manifestations (univariate analysis) were: age ≥ 60 years, female gender, virus transmission by blood transfusions, longstanding infection (≥ 20 years), and extensive liver fibrosis. The most significant risks factors (multivariate analysis) were longstanding infection and extensive liver fibrosis. CONCLUSION:We observed a high prevalence of extrahepatic manifestations in patients with chronic HCV infection. Most of these manifestations were associated with impaired lymphoproliferation and cryoglobulin production. Longstanding infection and extensive liver fibrosis were significant risk factors for the presence of extrahepatic manifestations in HCV patients.

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Section: Discussionmentioning

confidence: 80%

Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients

Stefanova-Petrova¹,

Tzvetanska²,

Naumova³

et al. 2007

WJG

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“…The rate of malignant transformation of these lesions is 3-20% (42). Furthermore, our study suggests the presence and elevation of HCV RNA in oral cancer and OLP tissues (43). Multi-center studies in Japan found that the presence of anti-HCV and HCV RNA was significantly higher in patients with squamous cell carcinoma of the head and neck than in control subjects (14).…”

Section: Discussionmentioning

confidence: 91%

Graves' ophthalmopathy and tongue cancer complicated by peg-interferon α-2b and ribavirin therapy for chronic hepatitis C: A case report and review of the literature

Nagao

Hiromatsu²,

Nakashima³

et al. 2008

Mol Med Rep

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Abstract. Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who developed Graves' ophthalmopathy and tongue cancer (malignant transformation of leukoplakia) while receiving peg-interferon (Peg-IFN) α-2b and ribavirin (RBV) treatment for chronic hepatitis C. This patient had no history of thyroid disease before the combination therapy, but did have bilateral leukoplakia of the tongue. The leukoplakia lesions did not change until 20 weeks after the start of the combination therapy, and ophthalmopathy was not diagnosed until 47 weeks later. As ophthalmopathy is considered to be a severe adverse event induced by Peg-IFN α-2b plus RBV, therapy was discontinued after 47 weeks. The patient received a partial glossectomy to remove the malignant neoplasm as well as extraocular muscle surgery for the ophthalmopathy, and was treated with an antithyroid agent and steroids. In conclusion, it is necessary to clinically examine organs other than the liver in patients with HCV infection.

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“…Samples positive for HCV-RNA were detected in tissues of oral cancer (19) and OLP (20). Some of HCV proteins, called "the core" and "the non-structural 3 protein", can accelerate the cell cycle in vitro (21,22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

et al. 2014

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The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection -Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment -Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV -Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool™ software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

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Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues

Cited by 110 publications

References 35 publications

Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients

Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients

Graves' ophthalmopathy and tongue cancer complicated by peg-interferon α-2b and ribavirin therapy for chronic hepatitis C: A case report and review of the literature

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

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