Detection of Herpesviruses and Periodontal Pathogens in Subgingival Plaque of Patients With Chronic Periodontitis, Generalized Aggressive Periodontitis, or Gingivitis

Imbronito, Ana Vitória; Okuda, Osmar Shizuo; Freitas, Nívea Maria de; Lotufo, Roberto Fraga Moreira; Nunes, Fábio Daumas

doi:10.1902/jop.2008.070388

Cited by 91 publications

(111 citation statements)

References 51 publications

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“…7,18,19 Although few studies showed similar detection rates of HCMV as in our study, there has been a wide and varied report with high levels of viruses to none in certain population with healthy periodontium. 7,9,17,18,[20][21][22][23] In CP, there have been varied reports with some studies finding very high levels of EBV and HCMV. 10,18,20,21,23 Our results showed significantly higher levels of both the HCMV and the EBV virus in CP as compared to the healthy periodontium but still was lower than the median range as quoted by Slots 2010.…”

Section: Discussionmentioning

confidence: 99%

“…7,9,17,18,[20][21][22][23] In CP, there have been varied reports with some studies finding very high levels of EBV and HCMV. 10,18,20,21,23 Our results showed significantly higher levels of both the HCMV and the EBV virus in CP as compared to the healthy periodontium but still was lower than the median range as quoted by Slots 2010. 2 In his study, we noted that a co-infection of HCMV and EBV existed in CP group and this relationship was significant.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of the present study were at lower levels as compared to some studies done in other countries. 18,[20][21][22][23] This could also be because the detection levels may depend on the virus being in the active or latent stage. The primary infection of the host with herpesvirus is followed by a state of latency and reactivation.…”

Section: A Study Done By Contreras Et Al In American Patientsmentioning

confidence: 99%

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Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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Objective: The identification of new uncultured species and viruses supports the possibility of combination of the herpesvirus-bacterial periodontal infection for periodontitis. The paucity of data and studies with larger sample size in Indian subjects provides an unclear picture of the presence of the herpesvirus in this population. Materials and methods:This was a cross-sectional study consisting of 100 each in the healthy group and chronic periodontitis (CP) group. The subgingival plaque was collected and polymerase chain reaction was performed post deoxyribonucleic acid (DNA) extraction by using specific primers for human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The data were analyzed using Fisher's exact test, Mann-Whitney U test and Spearman's coefficient correlation.Results: Human cytomegalovirus and EBV viruses were significantly higher in the CP group as compare to the healthy group. A higher percentage of those with CMV positive had EBV also positive (28.3%) compared to only 9.1% of CMV negative being EBV positive in the CP group. When both the healthy and CP group in total was compared, there was a significant correlation with all clinical parameters. Conclusion:Both the viruses dominated in disease as compared to health were similar to the earlier findings. The CP group had higher pocket depth and clinical attachment loss in the virus positive subjects. These findings could suggest that 91-9620127630, e-mail: drvinayakjoshi@gmail.com virus serves as a prelude to the disease and the combination of the two viruses could play a role in the pathogenesis. Prevalence of Herpesvirus and Correlation with Clinical

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: A Study Done By Contreras Et Al In American Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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“…Subgingival microflora in gingivitis represent a transition between that associated with health and periodontitis, 38 in which subgingival microflora shifts from being predominately gram-positive to an increased number of obligate anaerobic gram-negative organisms, such as Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Selenomonas noxia, as well as Campylobacter rectus, Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, and Prevotella intermedia, and spirochetes. [35][36][37][38][39][40][41] Other microorganisms found in PD include Chlamydophila pneumoniae 42 ; Mycoplasma 43,44 ; Helicobacter pylori [45][46][47] ; candida 48 -51 ; Epstein-Barr virus, cytomegalovirus, and herpesviruses [52][53][54] ; ameba 55 ; methane-producing microorganisms called archaea 56 -59 ; and sulfate-reducing bacteria and archaea. 60,61 Epithelium in the gingival sulcus interacts with bacteria in the subgingival crevicular space, generating and transmitting signals between bacteria and adjacent immune cells.…”

Section: Methanogenic Archaeamentioning

confidence: 99%

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

Lockhart

Bolger²,

Papapanou³

et al. 2012

Circulation

890

814

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Abstract-A link between oral health and cardiovascular disease has been proposed for more than a century. Recently, concern about possible links between periodontal disease (PD) and atherosclerotic vascular disease (ASVD) has intensified and is driving an active field of investigation into possible association and causality. The 2 disorders share several common risk factors, including cigarette smoking, age, and diabetes mellitus. Patients and providers are increasingly presented with claims that PD treatment strategies offer ASVD protection; these claims are often endorsed by professional and industrial stakeholders. The focus of this review is to assess whether available data support an independent association between ASVD and PD and whether PD treatment might modify ASVD risks or outcomes. It also presents mechanistic details of both PD and ASVD relevant to this topic. The correlation of PD with ASVD outcomes and surrogate markers is discussed, as well as the correlation of response to PD therapy with ASVD event rates. Methodological issues that complicate studies of this association are outlined, with an emphasis on the terms and metrics that would be applicable in future studies. Observational studies to date support an association between PD and ASVD independent of known confounders. They do not, however, support a causative relationship. Although periodontal interventions result in a reduction in systemic inflammation and endothelial dysfunction in short-term studies, there is no evidence that they prevent ASVD or modify its outcomes. (Circulation. 2012;125:2520-2544.)

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“…Herpes viruses may contribute to the pathogenesis of chronic and aggressive periodontitis (Table 4). There is speculation that Epstein-Barr virus-1 (EBV-1) and cytomegalovirus (CMV) may be involved in synergistic mechanisms with Aa, P. gingivalis and T. forsythia (Chalabi et al, 2010;Dawson et al, 2009;Imbronito et al, 2008;Slots 2010, Fritschi et al, 2008. Table 4.…”

Section: Plaque In Chronic Periodontitismentioning

confidence: 99%

The Microbial Aetiology of Periodontal Diseases

Africa¹

2012

Periodontal Diseases - A Clinician's Guide

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Detection of Herpesviruses and Periodontal Pathogens in Subgingival Plaque of Patients With Chronic Periodontitis, Generalized Aggressive Periodontitis, or Gingivitis

Abstract: In Brazilian patients, HSV-1 and EBV-1, rather than HCMV, were more frequently associated with CP and AgP.

Cited by 91 publications

References 51 publications

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

The Microbial Aetiology of Periodontal Diseases

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