Detection of High-Risk Sessile Serrated Lesions: Multitarget Stool DNA Versus CT Colonography

Deiss-Yehiely, Nimrod; Graffy, Peter M; Weigman, Benjamin; Hassan, Cesare; Pickhardt, Perry J.; Weiss, Jennifer M.

doi:10.2214/ajr.21.26719

Cited by 3 publications

(6 citation statements)

References 38 publications

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“…Seventy-five full-length articles were assessed for inclusion and 23 studies were included in the final analysis . Sixteen studies reported SSPDR after only FIT testing [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], 3 reported SSPDR on both FIT and FIT-DNA [35][36][37]; and 3 studies reported SSPDR after only FIT-DNA testing (Figure 1) [38][39][40][41].…”

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

“…Sixteen studies reported SSPDR after only FIT testing [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34], three reported SSPDR on both FIT and FIT-DNA [35,36,37], and three studies reported SSPDR after only FIT-DNA testing (▶ Fig. 1) [38,39,40,41].…”

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

“…A total of 410 studies were found on the initial search, of which 309 records were screened after removing duplicates. Seventyfive full-length articles were assessed for inclusion and 23 studies were included in the final analysis [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41]. Sixteen studies reported SSPDR after only FIT testing [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34], three reported SSPDR on both FIT and FIT-DNA [35,36,37], and three studies reported SSPDR after only FIT-DNA testing (▶ Fig.…”

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

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Sessile serrated polyp detection rates after fecal immunochemical test or multitarget stool DNA test: Systematic review and meta-analysis

Garg,

Burke,

Aggarwal

et al. 2024

Endosc Int Open

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Background: Published studies report a higher adenoma detection rate (ADR) for FIT-DNA as compared to FIT. Data is less replete on the performance of stool-based tests on sessile serrated polyp (SSP) detection. We performed meta-analysis to evaluate the performance of FIT and FIT-DNA test on SSP detection rate (SSPDR) for patients undergoing colonoscopy for follow up of positive noninvasive tests. Methods A comprehensive literature search of multiple databases (until September 2022) was performed to identify studies reporting SSPDR in patients with positive FIT or FIT-DNA. The outcome was overall colonoscopy detection of any SSP and an advanced serrated polyps (ASP: SSP ≥ 10 mm and/or dysplasia) Results 482,405 (52.4% females) patients with a mean age of 62.3 ± 4.4 years were included from 23 studies. The pooled SSPDR for all positive stool-based tests was 5.3% and higher for FIT-DNA (15.0%, 95% CI: 8.3 – 25.7) versus FIT (4.1%, 95% CI: 3.0 – 5.6; p=0.0002). The overall pooled ASP detection rate was 1.4% (95% CI: 0.81 – 2.3) and higher in FIT-DNA (3.8 %, 95% CI: 1.7 – 8.6) compared to FIT (0.71%, 95% CI: 0.36 – 1.4; p< 0.01). SSPDR with FIT-DNA was also significantly higher than FIT where FIT cutoff was >10 ug/g and in FIT positive patients in studies conducted in North America (p<0.05). Conclusion FIT-DNA outperformed FIT in both SSP and ASP detection including FIT with a lower threshold cutoff >10 ug/g. Further comparative studies are needed to assess impact of our findings on colorectal cancer reduction.

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Section: Search Results and Population Characteristicsmentioning

confidence: 99%

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

Section: Search Results and Population Characteristicsmentioning

confidence: 99%

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Sessile serrated polyp detection rates after fecal immunochemical test or multitarget stool DNA test: Systematic review and meta-analysis

Garg,

Burke,

Aggarwal

et al. 2024

Endosc Int Open

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“…26 definition, detection strategies and histopathologic assessment. 45 A small proportion of these lesions (Type IIC = central depression) are more aggressive than their counterparts; this risk has been incorrectly assigned to all flat lesions. Awareness of their typical morphology and location can help improve diagnostic accuracy in the detection and reporting of these lesions.…”

Section: Flat/serrated Lesionsmentioning

confidence: 99%

“…44 There is a wide variation in reported prevalence due to lack of consensus on the definition, detection strategies and histopathologic assessment. 45 A small proportion of these lesions (Type IIC = central depression) are more aggressive than their counterparts; this risk has been incorrectly assigned to all flat lesions.…”

Section: Flat/serrated Lesionsmentioning

confidence: 99%

Canadian Association of Radiologists Practice Guidelines for Computed Tomography Colonography

Chawla

Hurrell²,

Keough

et al. 2023

Can Assoc Radiol J

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Colon cancer is the third most common malignancy in Canada. Computed tomography colonography (CTC) provides a creditable and validated option for colon screening and assessment of known pathology in patients for whom conventional colonoscopy is contraindicated or where patients self-select to use imaging as their primary modality for initial colonic assessment. This updated guideline aims to provide a toolkit for both experienced imagers (and technologists) and for those considering launching this examination in their practice. There is guidance for reporting, optimal exam preparation, tips for problem solving to attain high quality examinations in challenging scenarios as well as suggestions for ongoing maintenance of competence. We also provide insight into the role of artificial intelligence and the utility of CTC in tumour staging of colorectal cancer. The appendices provide more detailed guidance into bowel preparation and reporting templates as well as useful information on polyp stratification and management strategies. Reading this guideline should equip the reader with the knowledge base to perform colonography but also provide an unbiased overview of its role in colon screening compared with other screening options.

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Editor's Notebook: April 2022

Rosenkrantz

2022

American Journal of Roentgenology

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Detection of High-Risk Sessile Serrated Lesions: Multitarget Stool DNA Versus CT Colonography

Cited by 3 publications

References 38 publications

Sessile serrated polyp detection rates after fecal immunochemical test or multitarget stool DNA test: Systematic review and meta-analysis

Sessile serrated polyp detection rates after fecal immunochemical test or multitarget stool DNA test: Systematic review and meta-analysis

Canadian Association of Radiologists Practice Guidelines for Computed Tomography Colonography

Editor's Notebook: April 2022

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