Detection of HIV-1 antigen by quartz crystal microbalance using gold nanoparticles

Ly, Tan Nhiem; Park, Sangkwon; Park, Sang Joon

doi:10.1016/j.snb.2016.06.112

Cited by 35 publications

(18 citation statements)

References 31 publications

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“…Quartz crystal microbalance (QCM) belongs to the larger group of BAW that has been studied extensively and applied to many fields. For example, coated QCM with antibody and gold nanoparticles has been used recently for disease diagnosis and antigen detection in solutions [ 70 , 71 , 72 , 73 , 74 ]. Study of cells can be conducted through the examination of cell-substrate adhesion with QCM [ 75 , 76 ].…”

Section: Gas Sensing Methodsmentioning

confidence: 99%

Affinity Ionic Liquids for Chemoselective Gas Sensing

Chang

Chang³

et al. 2018

Molecules

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Selective gas sensing is of great importance for applications in health, safety, military, industry and environment. Many man-made and naturally occurring volatile organic compounds (VOCs) can harmfully affect human health or cause impairment to the environment. Gas analysis based on different principles has been developed to convert gaseous analytes into readable output signals. However, gas sensors such as metal-oxide semiconductors suffer from high operating temperatures that are impractical and therefore have limited its applications. The cost-effective quartz crystal microbalance (QCM) device represents an excellent platform if sensitive, selective and versatile sensing materials were available. Recent advances in affinity ionic liquids (AILs) have led them to incorporation with QCM to be highly sensitive for real-time detection of target gases at ambient temperature. The tailorable functional groups in AIL structures allow for chemoselective reaction with target analytes for single digit parts-per-billion detection on mass-sensitive QCM. This structural diversity makes AILs promising for the creation of a library of chemical sensor arrays that could be designed to efficiently detect gas mixtures simultaneously as a potential electronic in future. This review first provides brief introduction to some conventional gas sensing technologies and then delivers the latest results on our development of chemoselective AIL-on-QCM methods.

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Section: Gas Sensing Methodsmentioning

confidence: 99%

Affinity Ionic Liquids for Chemoselective Gas Sensing

Chang

Chang³

et al. 2018

Molecules

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“…By using a (Pb(Mg 1/3 Nb 2/3 )O 3 ) 0.65 (PbTiO 3 ) 0.35 (i.e., PMN-PT) piezoelectric plate sensor coated with probe DNA, in situ detection of HBV double mutation (HBVDM) in urine has been previously discussed. [94] The PMN-PT layer coated with [90] Copyright 2016, Elsevier.…”

Section: Hepatitis B Virus: Group VIImentioning

confidence: 99%

“…HIV‐1 antigens were detected by the QCM using AuNPs as a signal enhancer. [ 90 ] The QCM sensor, consisting of cavity resonators constructed over a piezoelectric substrate, would accumulate electric charges in response to the applied stress. Four AuNPs of different sizes were prepared (see Figure a).…”

Section: Piezoelectric Biosensorsmentioning

confidence: 99%

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

et al. 2020

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fever with or without chills, chest tightness, dry cough, and shortness of breath, while developing patchy to diffuse infiltration of the lungs, as shown radiographically in Figure 1. Identifying and monitoring SARS-CoV-2 infection has become crucially important. A recent projection of the transmission dynamics of SARS-CoV-2 [2] showed that longitudinal serological studies are desperately needed to determine the extent and duration of immunity to SARS-CoV-2. Even in the event of apparent elimination, maintenance of SARS-CoV-2 surveillance is still needed because of a possible resurgence of contagion. In the past, notable viruses have emerged suddenly from obscurity or anonymity, provoking concern from the point of view of immunology regarding their sustained epidemic transmission in naive human populations. More than 70% of these infections have been zoonotic, entering either directly from wild animal reservoirs or indirectly via an intermediate domestic animal host. [3] Ebola virus, avian influenza, human immunodeficiency virus (HIV), and SARS are all examples of zoonoses that have emerged from wild animals, presenting an increasingly serious threat to human health and economies worldwide. Figure 2 shows the trend in the number of people infected with SARS-CoV-2. [4] The spread of the severe acute respiratory syndrome coronavirus has changed the lives of people around the world with a huge impact on economies and societies. The development of wearable sensors that can continuously monitor the environment for viruses may become an important research area. Here, the state of the art of research on biosensor materials for virus detection is reviewed. A general description of the principles for virus detection is included, along with a critique of the experimental work dedicated to various virus sensors, and a summary of their detection limitations. The piezoelectric sensors used for the detection of human papilloma, vaccinia, dengue, Ebola, influenza A, human immunodeficiency, and hepatitis B viruses are examined in the first section; then the second part deals with magnetostrictive sensors for the detection of bacterial spores, proteins, and classical swine fever. In addition, progress related to early detection of COVID-19 (coronavirus disease 2019) is discussed in the final section, where remaining challenges in the field are also identified. It is believed that this review will guide material researchers in their future work of developing smart biosensors, which can further improve detection sensitivity in monitoring currently known and future virus threats.

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“…As such, the process of functionalising sensor surfaces with epitopes is usually less tedious ( Gerdon et al, 2005 ). However, this method is less useful for early detection due to the existence of a window period of up to several months before a detectable level of antibodies is produced in the body ( Ly et al, 2016 ; Su et al, 2003 ).…”

Section: Receptors For Target Recognitionmentioning

confidence: 99%

“…Another recognised approach for detecting HIV infections is to target the p24 capsid protein of the virus, which is a virological marker that appears earlier than the anti-HIV antibodies by more than a week ( Gillespie et al, 2019 ; Kirsch et al, 2013 ). Ly et al (2016) demonstrated the feasibility of detecting p24 using a QCM immunosensor coupled with AuNPs for signal enhancement. The immunosensor had a wide detection range (1–10 7 ng mL -1 ).…”

Section: Qcm-based Biosensors For Prevalent Infectious Diseasesmentioning

confidence: 99%

Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases

Lim

Saha

Tey

et al. 2020

Biosensors and Bioelectronics

160

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Infectious diseases are the ever-present threats to public health and the global economy. Accurate and timely diagnosis is crucial to impede the progression of a disease and break the chain of transmission. Conventional diagnostic techniques are typically time-consuming and costly, making them inefficient for early diagnosis of infections and inconvenient for use at the point of care. Developments of sensitive, rapid, and affordable diagnostic methods are necessary to improve the clinical management of infectious diseases. Quartz crystal microbalance (QCM) systems have emerged as a robust biosensing platform due to their label-free mechanism, which allows the detection and quantification of a wide range of biomolecules. The high sensitivity and short detection time offered by QCM-based biosensors are attractive for the early detection of infections and the routine monitoring of disease progression. Herein, the strategies employed in QCM-based biosensors for the detection of infectious diseases are extensively reviewed, with a focus on prevalent diseases for which improved diagnostic techniques are in high demand. The challenges to the clinical application of QCM-based biosensors are highlighted, along with an outline of the future scope of research in QCM-based diagnostics.

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Detection of HIV-1 antigen by quartz crystal microbalance using gold nanoparticles

Cited by 35 publications

References 31 publications

Affinity Ionic Liquids for Chemoselective Gas Sensing

Affinity Ionic Liquids for Chemoselective Gas Sensing

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other Viruses

Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases

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