Detection of HIV DNA in cervical and vaginal secretions: Prevalence and correlates among women in Nairobi, Kenya

Abstract

Objective.\p=m-\Factors that influence heterosexual transmission of the human immunodeficiency virus (HIV)

Evidence for benefits from treating cervical ectopy: literature review

“…In a cross-sectional study on 97 HIVpositive women, Clemetson et al 18 found a higher frequency of HIV isolation from the cervix and vagina in the women with ectopy. This association remained in the multivariate analysis: OR = 5; 95% CI = 1.5-16.9; p = 0.006.…”

Binding of LFA-1 (CD11a) to Intercellular Adhesion Molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) Triggers Transmigration of Human Immunodeficiency Virus Type 1-Infected Monocytes through Mucosal Epithelial Cells

“…The phenotype of genital HIV strains is primarily macrophage-tropic and non-syncytium-inducing (13). We elected to use MDM as target cells for HIV infection and as migrating cells, since genital tract tissues from HIV-infected individuals contain high levels of HIV-infected monocytes (12,25,46). Spira et al demonstrated that the first target cells for infection, observed within 2 days of intravaginal inoculation of simian immunodeficiency virus in macaques, are mononuclear cells in the lamina propria of the cervicovaginal mucosa (41).…”

PCR tests for uterine cervical secretion are promising noninvasive methods for predicting congenital cytomegalovirus infection

“…Indeed, culture of GBS and polymerase chain reaction (PCR) tests for the detection of Chlamydia trachomatis in the genital secretions are widely used as maternal screening tools to prevent intrapartum mother-to-infant transmission of these pathogens. In previous studies, it was reported that the presence of viral DNA, including hepatitis B virus, human immunodeficiency virus (HIV), and HPV, in the maternal uterine cervical secretion or vaginal secretion may be a risk factor for mother-to-child transmission of viruses [1][2][3]. However, there have been no studies that evaluate the usability of PCR tests for CMV-DNA in the uterine cervical secretion as a tool for predicting congenital CMV infection before birth.…”