Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood

Holloway, Judith A.; Warner, John O.; Vance, Gillian; Diaper, Norma D.; Warner, Jill A.; Jones, C. H. W.

doi:10.1016/s0140-6736(00)03265-7

Cited by 153 publications

(97 citation statements)

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“…The main indicator of airflow obstruction, enhanced pause (Penh), which shows strong correlation with the airway resistance examined by standard evaluation methods, was calculated from the box waveform (22). After measurement of baseline Penh, aerosolized PBS or methacholine in increasing concentrations (6,12,25,50, and 100 mg/ml) was nebulized through an inlet of the chamber for 1 min, and Penh measurements were taken for 9 min after each dose. Penh values for the first 5 min after each nebulization were averaged and used to compare results across treatment groups and individual mice.…”

Section: Pulmonary Function Testingmentioning

confidence: 99%

“…Indeed, epidemiologic studies report the intriguing finding that maternal, more than paternal, asthma is a significant risk factor for development of asthma (2)(3)(4). This finding has prompted speculation about potential pathways for maternal influence on the fetal immune system, including transfer of mediator(s) from mother to child (e.g., allergens (5,6), Abs (7), or other immune mediators via the placenta (8,9)), which might prime or sensitize the developing individual for increased susceptibility to asthma (10,11). These postulates reflect experimental data demonstrating newborn immune responses to maternal vaccines or Ags in the maternal environment (5,12,13), but are somewhat in conflict with earlier observations that transfer of maternal Ag-specific IgG may protect against allergy by suppressing neonatal IgE responses (14).…”

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confidence: 99%

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Allergen-Independent Maternal Transmission of Asthma Susceptibility

Hamada

Suzaki

Goldman

et al. 2003

The Journal of Immunology

125

175

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Maternal asthma is a risk factor for development of asthma in children, but mechanisms remain unclear. Offspring of asthmatic mother mice (sensitized and repeatedly exposed to OVA Ag) showed airway hyperresponsiveness and allergic pulmonary inflammation after an intentionally suboptimal OVA sensitization and exposure protocol that had little effect on normal offspring. Similar results were obtained when offspring of OVA-allergic mothers were exposed to an unrelated allergen, casein, indicating that the maternal effect is allergen independent and not transferred by OVA-specific Abs. Premating treatment with neutralizing anti-IL-4 Ab or reduction of maternal allergen exposure abrogated the maternal effect, showing a critical mechanistic role for IL-4 and suggesting an additional benefit of allergen avoidance.

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Section: Pulmonary Function Testingmentioning

confidence: 99%

mentioning

confidence: 99%

Allergen-Independent Maternal Transmission of Asthma Susceptibility

Hamada

Suzaki

Goldman

et al. 2003

The Journal of Immunology

125

175

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“…As the prevalence of asthma is still increasing [4][5][6][7][8], much attention is being directed towards the possibilities for primary prevention. It is generally agreed that asthma is a multifactorial disease, which develops in very early life or even in the uterus [9][10][11][12].…”

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confidence: 99%

The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma

Schönberger

Dompeling²,

Knottnerus³

et al. 2005

Eur Respir J

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As asthma is the most common chronic disease in childhood, much attention is directed towards primary prevention. Here, the clinical effectiveness of a multifaceted educational prevention was studied.A total of 476 high-risk children were recruited during the prenatal period by general practitioners and randomised to either: 1) a control group, receiving usual care; or 2) an intervention group in which families received instruction from nurses on how to reduce exposure of newborns to mite, pet and food allergens, and passive smoking.A total of 443 infants were followed-up for 2 yrs. At 2 yrs of age, the intervention group (n5222) had less asthma-like symptoms, including wheezing, shortness of breath and night-time cough, than the control group (n5221). No significant differences in total and specific immunoglobulin E were found between the groups. During the first 2 yrs of life, the incidence of asthma-like symptoms was similar in both groups; however, subanalysis revealed a significant reduction in the female, but not in the male, intervention group.In conclusion, the intervention used in this study was not effective in reducing asthma-like symptoms in high-risk children during the first 2 yrs of life, although it was modestly effective at 2 yrs. Follow-up is necessary to confirm whether the intervention can actually prevent the development of asthma.

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“…The recommendation for mothers to implement a PN restrictive diet during pregnancy/lactation was abandoned in 2008 [6] due to the lack of conclusive evidence of benefit [7], and early evidence that it might even be harmful [8,9]. The theory behind the early life PN restriction diet is mainly based on the conception of "in utero or early life sensitization" based on the findings of allergens/antibodies presented in amniotic fluid and cord blood [10], and placenta [11,12] and peanut antigen in breast milk of lactation women after ingestion of PN [13], although studies providing a direct association of offspring sensitization were lacking. Recently, an alternative hypothesis that early life introduction of PN or other allergenic foods may be beneficial because oral tolerance induction is an active process that requires antigen has been put forward [14,15].…”

Section: Clinical Studiesmentioning

confidence: 99%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

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Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood

Cited by 153 publications

References 4 publications

Allergen-Independent Maternal Transmission of Asthma Susceptibility

Allergen-Independent Maternal Transmission of Asthma Susceptibility

The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

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