Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters

Das, Sushma; Krithiga, G Shobha Prakash; Gopalakrishnan, S.

doi:10.4103/0973-029x.98502

Cited by 51 publications

(71 citation statements)

References 21 publications

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“…The possible reason why these same results were not found in our study are the age range, ethnic differences, the limited sample size, the methodology used, and the probable stage of herpes virus latency. Das et al (2012) carried out a study to detect the presence of human cytomegalovirus (HCMV), Epstein barr virus (EBV), and herpes simplex virus (HSV-1 and HSV-2) in chronic periodontitis, aggressive periodontitis, and healthy individuals divided into three groups: periodontally healthy individuals aged ≥ 21 years -45 years with a sulcus depth ≤ 3 mm; chronic periodontitis in patients aged ≥ 35 years, with 30% of sites involved, a periodontal pocket depth ≥ 6 mm, and an attachment loss ≥ 3 mm, with severe bone loss (≥50% of root length) and patients with aggressive periodontitis aged ≥ 18 years, with 30% of sites involved, a periodontal pocket depth ≥ 6 mm, and an attachment loss ≥ 3 mm, with severe bone loss (≥50% of root length). In these patients HSV-1 was detected in sites with chronic periodontitis in 76% in sites with aggressive periodontitis in 80%; EBV was detected in 32% of sites of chronic periodontitis and aggressive periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Among the herpesviruses, herpes simplex 1 and 2 (HSV-1, HSV-2) are common causes of infection (Chayavichitsilp et al, 2009). Some studies have found a relationship between these subspecies and periodontal disease (Das et al, 2012). Other studies have found these subspecies both in patients with periodontal disease and in periodontally healthy patients, although HSV was more frequent in periodontitis lesions (Contreras et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Other studies have found these subspecies both in patients with periodontal disease and in periodontally healthy patients, although HSV was more frequent in periodontitis lesions (Contreras et al, 2000). The action of herpesviruses is to infect and impair polymorphonuclear leukocytes, macrophages, and lymphocytes (Das et al, 2012). Endothelial cells infected with herpes virus can reduce host defenses and favor overgrowth of pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Herpesviruses have emerged as putative pathogens in periodontal disease since the 1990s (Pawar et al, 2012 periodontal tissue (Contreras et al, 2000). Human cytomegalovirus (HCMV), Epstein-Barr virus type 1 (EBV-1) and Herpes simplex virus (HSV) have been reported to play a role in the pathogenesis of severe types of periodontitis (Das et al, 2012;Pawar et al, 2012). Among the herpesviruses, herpes simplex 1 and 2 (HSV-1, HSV-2) are common causes of infection (Chayavichitsilp et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Mauricio¹,

Ernesto²,

Rosa³

et al. 2013

Afr. J. Microbiol. Res.

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Periodontitis is an inflammatory process that occurs in the tissues surrounding the teeth. It is caused by microorganisms and groups of microorganisms and results in loss of periodontal ligament and alveolar bone. Herpes virus has emerged as a putative pathogen in periodontal disease. Periodontal disease was demonstrated in 50 patients by careful probing of pockets and completion of a medical record. Three saliva samples were collected in individuals with deep pockets. Samples were obtained with a sterile swab and placed in 10% glucose solution for storage at -80°C. DNA purification and PCR, in addition to electrophoresis, were performed. Of the 50 samples processed, two were positive for HSV-1 and two for HSV-2. Three were from women with mild, moderate, and severe chronic periodontitis, respectively, and one (HSV-1) from a man with mild chronic periodontitis. Due to the low prevalence of herpes simplex virus in periodontal pockets, it was not possible to determine its role in the progression of periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Mauricio¹,

Ernesto²,

Rosa³

et al. 2013

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

show abstract

“…In patients with aggressive periodontitis, the microbial load of P. intermedia correlates with the loss of the level of clinical attachment. [26] In vitro demonstrated that P. intermedia LPS causes expression of pro-inflammatory cytokines by gingival epitheliocytes of a gum and human periodontal ligament cells. [27] C. rectus…”

Section: P Intermediamentioning

confidence: 99%

Untitled

Batyrbekova¹

2017

AJP

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Pyoinflammatory diseases of maxillofacial area (MFA) are one of the most serious problems of maxillofacial surgery. The high medical and social significance of these diseases are due to their frequent occurrence in persons of working age and the risk of life-threatening complications: Bleeding from the great vessel, brain abscess, the spread of infection into the deep cellular spatium of the collum. In more than 1/3 of all patients, pyogenic lesions of MFA develop on the background of secondary immunodeficiency, accompanied by impaired regulation of the secretion of pro-inflammatory cytokines, and predisposing to prolonged smoldering flow or, on the contrary, rapid spread of inflammation with extensive tissue damage. This fact determines the importance of developing integrated approaches to diagnostics and treatment. The aim of the study is to generalize modern ideas about causative agents and their effect on the features of the inflammatory diseases of the MFA. We systematized and analyzed contemporary works of Russian and foreign authors on the study of the effects of causative agents of bacterial and viral nature and characteristic changes in the immune status. The modern data on the role of microbial factors in the development and maintenance of local and systemic immunological status disorders in case of inflammatory disease of MFA are presented, the impact on the development of bacterial and viral microflora diseases is given, with special attention paid to immunomodulatory effects of causative agents. The factors of pathogens influence most frequently associated with inflammatory diseases of theMFA and collum, as well as the relationship of individual microorganisms with the clinical manifestations of this pathology type and the detection of the pathogenetic role of immune disorders, allow to conduct studies on the formation of optimal correction schemes for each patient (personified) depending on the features of the course of the disease.

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Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Fang,

Liu,

Mao

et al. 2024

Journal of Medical Virology

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Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis. The data from the US National Health and Nutrition Examination Survey (NHANES) 2009−2014 was adopted and screened through, including 10 714 participants. Generalized linear regression was conducted to verify the relationships between the virus infections and periodontitis. Moreover, we also performed analyses in age and gender subgroups. The results suggested that the infection of HCV, HSV‐1, and HSV‐2 was significantly associated with the prevalence of periodontitis (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.26−1.70; OR 1.09, 95% CI 1.05−1.13; OR 1.06, 95% CI 1.01 ‐ 1.11, respectively) and risk of developing moderate or severe periodontitis (OR 1.51, 95% CI 1.29−1.77; OR 1.08, 95% CI 1.04−1.12; OR 1.05, 95% CI 1.01−1.10, respectively) after adjusting all relevant co‐factors. Subgroup analyses revealed a steady association between periodontitis and hepatitis C virus (HCV) or HSV‐1 infection, while the relationship between HSV‐2 and HPV infection can also be found in some subgroups. The presence of HCV and HSV infection was found to be significantly associated with the prevalence of periodontitis, including moderate or severe cases. Moreover, the association of periodontitis and HPV infection can also be observed in people < 35 years.

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Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters

Cited by 51 publications

References 21 publications

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Untitled

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

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